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LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells.

Abstract：

:Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancers and the leading cause of cancer-related death for both men and women. Recent studies have revealed that a small sub-population of cancer cells, termed cancer stem-like cells (CSCs)/cancer-initiating cells (CICs), are endowed with tumor-initiating ability, self-renewal ability and differentiation ability. CSCs/CICs are resistant to current therapies including chemotherapy and radiotherapy. Thus, CSCs/CICs are responsible for recurrence and metastasis, and eradication of CSCs/CICs is essential to cure cancer. In this study, we isolated CR-CSCs/CICs as sphere-cultured cells and found that a product derived from LY6/PLAUR domain containing 3 (LYPD3) is preferentially expressed in CSCs/CICs. Gene overexpression and gene knockdown experiments revealed that LYPD3 has a role in the maintenance of CR-CSCs/CICs. The findings provide a novel molecular insight into CR-CSCs/CICs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang L,Hirohashi Y,Ogawa T,Shen M,Takeda R,Murai A,Yamamoto E,Kubo T,Nakatsugawa M,Kanaseki T,Tsukahara T,Nishidate T,Okita K,Kutomi G,Sato N,Takemasa I,Torigoe T

doi

10.1016/j.bbrc.2017.02.112

subject

Has Abstract

pub_date

2017-04-29 00:00:00

pages

232-238

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)30403-5

journal_volume

486

pub_type

杂志文章

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