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Synthesis and in vitro activity of a hormone-diphtheria toxin fragment A hybrid.

Abstract：

:The synthesis and in vitro biological activity of a hybrid protein composed of intact human chorionic gonadotropin and fragment A of diphtheria toxin in a disulfide conjugate is reported. This hybrid retained greater than 90% of the binding ability of uncoupled hCG and was shown to be specifically toxic to a mouse Leydig cell tumor which binds hCG while being non-toxic towards cells which lack receptors for hCG.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Oeltmann TN

doi

10.1016/0006-291x(85)90924-6

subject

Has Abstract

pub_date

1985-12-17 00:00:00

pages

430-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90924-6

journal_volume

133

pub_type

杂志文章

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