The selection of the first AUG as the initiator of eucaryotic mRNAs translation is favored by a 5'-terminal cap group and a purine in the -3' position.

abstract：:We have isolated and characterized the cDNA encoding a novel protein designated DJ-1. DJ-1, sharing no significant homology with the sequences so far reported, did not show transactivation activity in the Gal4 recombinant system, but transformed mouse NIH3T3 cells by itself. Furthermore, DJ-1 showed a cooperative tran...

journal_title：Biochemical and biophysical research communications

authors： Nagakubo D,Taira T,Kitaura H,Ikeda M,Tamai K,Iguchi-Ariga SM,Ariga H

更新日期：1997-02-13 00:00:00

abstract：:The potential of liposomes to deliver functional proteins in retinal photoreceptors and modulate their physiological response was investigated by two experimental approaches. First, we treated isolated mouse retinas with liposomes encapsulating either recoverin, an important endogenous protein operating in visual phot...

journal_title：Biochemical and biophysical research communications

authors： Asteriti S,Dal Cortivo G,Pontelli V,Cangiano L,Buffelli M,Dell'Orco D

更新日期：2015-06-12 00:00:00

abstract：:It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Because our lab has shown that lipoic acid (LA) improves lipid homeostasis ...

journal_title：Biochemical and biophysical research communications

authors： Keith D,Finlay L,Butler J,Gómez L,Smith E,Moreau R,Hagen T

更新日期：2014-07-18 00:00:00

abstract：:Previous studies suggested that the hydrophobic protein chargerin II, which is encoded in the A6L of mitochondrial DNA, may have a key role in the energy transduction by mitochondrial H(+)-ATP synthase because an antibody against chargerin II inhibited ATP synthesis and ATP-Pi exchange, in an energy-dependent fashion....

journal_title：Biochemical and biophysical research communications

authors： Muraguchi M,Yoshihara Y,Tunemitu T,Tani I,Higuti T

更新日期：1990-04-16 00:00:00

abstract：:At 10 microM, 1-0-oleoyl-, 1-0-palmitoyl-, and 1-0-myristoyl-2-0-acetyl-glycerol weakly stimulated neutrophils to release lysozyme, an enzyme in secondary granules, but had no such effect on the release of a primary granule enzyme, beta-glucuronidase. The glycerides (1-10 microM) had a second effect on both granule po...

journal_title：Biochemical and biophysical research communications

authors： O'Flaherty JT,Schmitt JD,McCall CE,Wykle RL

更新日期：1984-08-30 00:00:00

abstract：:To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypo...

journal_title：Biochemical and biophysical research communications

authors： Kohno M,Takaori K,Matsuura T,Murakawa K,Kanayama Y,Takeda T

更新日期：1986-01-14 00:00:00

abstract：:The ability of cholecystokinin (CCK) to elevate intracellular Ca2+ levels in small cell lung cancer cells was investigated using the fluorescent Ca2+ indicator Fura 2. CCK-8 elevated the cytosolic Ca2+ levels in cell line NCI-H345 in a dose dependent manner. Nanomolar concentration of CCK-8 elevated cytosolic Ca2+ lev...

journal_title：Biochemical and biophysical research communications

authors： Staley J,Fiskum G,Moody TW

更新日期：1989-08-30 00:00:00

abstract：:Atrazine is a widely used triazine herbicide. Although controversy still exists, a number of recent studies have described its adverse effects on various animals including humans. Of particular interest is its effects on reproductive capacity. In this study, we investigated the mechanisms underlying the adverse effect...

journal_title：Biochemical and biophysical research communications

authors： Hase Y,Tatsuno M,Nishi T,Kataoka K,Kabe Y,Yamaguchi Y,Ozawa N,Natori M,Handa H,Watanabe H

更新日期：2008-02-01 00:00:00

abstract：:The 5-HT2A receptor is a target for hallucinogenic and non-hallucinogenic ligands that evoke unique behavioral, electrophysiological and molecular consequences. Here, we explored the differential effects of distinct 5-HT2A receptor ligands on signaling pathways downstream to the 5-HT2A receptor. The hallucinogenic 5-H...

journal_title：Biochemical and biophysical research communications

authors： Banerjee AA,Vaidya VA

更新日期：2020-10-22 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may play important roles during hepatitis B virus (HBV) infection. In this study, we used a recombinant human soluble death receptor 5 (sDR5) to explore its effect in a mouse model of HBV-induced acute hepatitis. By measuring blood transaminase activity a...

journal_title：Biochemical and biophysical research communications

authors： Liu YG,Liu SX,Liang XH,Zhang Q,Gao LF,Han LH,Cao YL,Hou N,Du J,Sun WS

更新日期：2007-01-12 00:00:00

abstract：:Several studies have shown that transplantation of embryonic stem cells into diabetic animals either improved or normalized blood glucose levels. In this study, we examined the dose-dependent effect of early (prediabetic stage) intravenous administration of human umbilical cord blood (HUCB) mononuclear cells on blood ...

journal_title：Biochemical and biophysical research communications

authors： Ende N,Chen R,Reddi AS

更新日期：2004-12-17 00:00:00

abstract：:CYP2A5 is a major enzyme responsible for nicotine and cotinine metabolism in mice. Nicotine and cotinine enhance alcoholic fatty liver in wild type (WT) mice but not in CYP2A5 knockout (KO) mice, and reactive oxygen species (ROS) generated during the CYP2A5-mediated metabolism contributes to the enhancing effect. In c...

journal_title：Biochemical and biophysical research communications

authors： Chen X,Wang K,Cederbaum AI,Lu Y

更新日期：2019-04-23 00:00:00

abstract：:Bovine rhodopsin was recombined with various phospholipids in which the lipid acyl chain composition was held constant at that of egg phosphatidylcholine (PC), while the identity of the headgroups was varied. The ratio of MII/MI produced in the recombinant membrane vesicles by an actinic flash was studied as a functio...

journal_title：Biochemical and biophysical research communications

authors： Gibson NJ,Brown MF

更新日期：1991-04-30 00:00:00

abstract：:Expression of facilitative glucose transporters (Glut 1, 2 and 3) was examined by Western blot analyses 10, 20 and 30 days following surgically induced unilateral abdominal cryptorchidism. The cryptorchid testes exhibited marked degenerative changes in the seminiferous tubules and spermatogonia, impaired and incomplet...

journal_title：Biochemical and biophysical research communications

authors： Farooqui SM,Al-Bagdadi F,O'Donnell JM,Stout R

更新日期：1997-07-18 00:00:00

abstract：:Chikungunya is a severe disease that results from infection with the chikungunya virus (CHIKV), an arbovirus. Thus, we (1) explored a new approach to combining previously researched drugs that have shown the potential to inhibit CHIKV infection; and (2) demonstrated the antiviral effects of (-)-Epigallocatechin-3-gall...

journal_title：Biochemical and biophysical research communications

authors： Lu JW,Hsieh PS,Lin CC,Hu MK,Huang SM,Wang YM,Liang CY,Gong Z,Ho YJ

更新日期：2017-09-23 00:00:00

abstract：:The effects of fibroblast growth factor (FGF) on testicular aromatase activity has been studied using primary cultures of porcine Leydig cells. After culture for 3 days in the absence or presence of FGF, the ability of the cells to produce estrogen was examined in a 4h-test period in which either (a) hCG (10(-9) M) or...

journal_title：Biochemical and biophysical research communications

authors： Raeside JI,Berthelon MC,Sanchez P,Saez JM

更新日期：1988-02-29 00:00:00

abstract：:Identification of new therapeutic targets may improve the survival rate of patients with colorectal cancer (CRC). Recent studies have suggested that the level of phosphodiesterase 4B (PDE4B) is elevated in fatal/refractory diffuse large B-cell lymphoma (DLBCL), and therapeutic efficacy of a PDE4 inhibitor in B-cell ly...

journal_title：Biochemical and biophysical research communications

authors： Kim DU,Kwak B,Kim SW

更新日期：2019-01-15 00:00:00

abstract：:The primary structure of the major hemoglobin component, HbA (alpha(A)- and beta-chain), from Tufted duck (Aythya fuligula) is presented. The separation of the globin subunits was achieved by ion exchange chromatography on CM-cellulose in 8 M urea. The amino acid sequence was determined by automatic Edman degradation ...

journal_title：Biochemical and biophysical research communications

authors： Abbasi A,Lutfullah G

更新日期：2002-02-15 00:00:00

abstract：:(-)Bay K 8644 produced a concentration-dependent contraction of porcine coronary artery rings with the maximal contraction at 10(-6) M. Pretreatment of the rings with 10(-6) M nitrendipine inhibited (-)Bay K 8644-induced contraction, while pretreatment with 10(-8) M nitrendipine potentiated the contraction elicited by...

journal_title：Biochemical and biophysical research communications

authors： Miwa K,Schwartz A

更新日期：1987-10-14 00:00:00

abstract：:The hpa cluster of Escherichia coli W ATCC 11105 encodes the enzymes involved in the catabolism of 4-hydroxyphenylacetate (4-HPA). The catabolic genes are organized in two operons, the hpaBC operon, which produces the hydroxylase activity, and the meta operon, which encodes the enzymes that cleave the aromatic ring an...

journal_title：Biochemical and biophysical research communications

authors： Prieto MA,García JL

更新日期：1997-03-27 00:00:00

abstract：:It is well known that the expression of osteocalcin, the only recognized osteoblast-specific protein, is regulated by 1 alpha-25-dihydroxyvitamin D3 through a distinct vitamin D3 receptor and a cis-acting DNA response element. In addition, recent data obtained with plasmid constructs have shown a positive interaction ...

journal_title：Biochemical and biophysical research communications

authors： Oliva A,Della Ragione F,Fratta M,Marrone G,Palumbo R,Zappia V

更新日期：1993-03-31 00:00:00

abstract：:A fractionation of the membrane extract of rat testes revealed the existence of pp60c-src kinase activity. The expression of pp60c-src was examined in the developing rat testes. The immunecomplex kinase assay using a monoclonal antibody specific to pp60c-src (mAb327) showed that the expression of pp60c-src kinase acti...

journal_title：Biochemical and biophysical research communications

authors： Nishio H,Tokuda M,Itano T,Matsui H,Takeuchi Y,Hatase O

更新日期：1995-01-17 00:00:00

abstract：:Micromolar concentrations of glucocorticoids rendered L-M cells (a murine tumorigenic fibroblast line) less sensitive to the cytotoxic activity of murine TNF. The potency of different steroids paralleled their known anti-inflammatory potency, and pretreatment was more effective than post treatment. Sex steroids and mi...

journal_title：Biochemical and biophysical research communications

authors： Kull FC Jr

更新日期：1988-05-31 00:00:00

abstract：:We examined the expression of dystrophin mRNA and the protein in the developing rat heart with polymerase chain reaction, immunoblotting and immunohistochemical analyses. Dystrophin mRNA was detectable on and after the 10th embryonic day, while the protein became detectable during the perinatal period. ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka H,Ozawa E

更新日期：1990-10-30 00:00:00

abstract：:Phosphatidylethanolamine-binding proteins (PEBPs) are found in various species and have multiple functions. In this study, we purified the swine homolog of human PEBP4 (sPEBP4) from swine seminal plasma, cloned the sPEBP4 cDNA and functionally characterized this protein. The molecular mass of the purified protein was ...

journal_title：Biochemical and biophysical research communications

authors： An LP,Maeda T,Sakaue T,Takeuchi K,Yamane T,Du PG,Ohkubo I,Ogita H

更新日期：2012-07-13 00:00:00

abstract：:First messengers and viral transfection are the two most common ways to stimulate cells for signal output, although their applications are limited. We investigated mechanisms of inducing neural stem cell differentiation using recombinant ephrin-B2/Fc and found that it acted as a ligand and inhibited endogenous ephrin-...

journal_title：Biochemical and biophysical research communications

authors： Xiaodong H,Zhen H,Min S,Zhiming C,Hongyan J,Chong Z,Xuefeng T,Guohua J

更新日期：2013-10-18 00:00:00

abstract：:Transglutaminase inhibitor (1,3,4,5-tetramethyl-2-[(2-oxopropyl)thio]imidazolium chloride or L-682777) affected the appearance of the fertilization envelope (FE) and subsequent development in Sphaerechinus granularis and Arbacia punctulata in a concentration-dependent manner. Abnormalities were first visible in formin...

journal_title：Biochemical and biophysical research communications

authors： Cariello L,Zanetti L,Lorand L

更新日期：1994-11-30 00:00:00

abstract：:Endothelial cells (EC) in vivo are exposed to a multitude of physical forces with each pulse of the cardiac cycle. Ongoing studies support the concept that EC respond to these forces through specific signal transduction pathways. Previous investigations in our laboratory have shown that EC respond to the initiation of...

journal_title：Biochemical and biophysical research communications

authors： Brophy CM,Mills I,Rosales O,Isales C,Sumpio BE

更新日期：1993-01-29 00:00:00

abstract：:Leprechaunism is an inherited disorder characterized by growth restriction and severe insulin resistance and caused by mutations in the insulin receptor gene. Cells from these patients have defective insulin binding. Fibroblasts from some patients have concomitant defects in other tyrosine kinase receptors, such as th...

journal_title：Biochemical and biophysical research communications

authors： Longo N

更新日期：1993-12-15 00:00:00

abstract：:The isolation and sequence analysis of the gene encoding the bovine atrial natriuretic peptide (ANP) precursor is described. The bovine-ANP coding sequences are located on three exons which are interrupted by two intervening sequences. Comparison of the bovine, human, rat and mouse ANP gene sequences reveals a common ...

journal_title：Biochemical and biophysical research communications

authors： Vlasuk GP,Miller J,Bencen GH,Lewicki JA

更新日期：1986-04-14 00:00:00