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Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa.

Abstract：

:The aims of this study are to identify the sex steroid-metabolizing cytochrome P450 enzymes of the vomeronasal organ (VNO) and to determine the activities of VNO microsomes to metabolize estradiol, progesterone, and testosterone. Several P450 isoforms, including CYP1A2, CYP2A, CYP2B, CYP2C, CYP2G1, and CYP3A, NADPH P450-reductase, and microsomal epoxide hydrolase were detected in mouse VNO, although their expression levels were much lower than those in the main olfactory epithelium. VNO microsomes were active toward the three steroid hormones, producing metabolite profiles similar to those seen with olfactory mucosal microsomes. Thus, the mammalian VNO, a steroid hormone target tissue, contains multiple steroid-metabolizing P450 isoforms and is capable of metabolic disposition of the three major sex steroid hormones. These findings support the proposed roles of olfactory mucosal and VNO microsomal P450 enzymes in maintaining cellular hormonal homeostasis and other perireceptor processes associated with olfactory chemosensory function.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Gu J,Dudley C,Su T,Spink DC,Zhang QY,Moss RL,Ding X

doi

10.1006/bbrc.1999.1807

subject

Has Abstract

pub_date

1999-12-09 00:00:00

pages

262-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)91807-7

journal_volume

266

pub_type

杂志文章

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