当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Inhibition of herpes simplex virus 1 reproduction with hydrophobized antisense oligonucleotides.

Inhibition of herpes simplex virus 1 reproduction with hydrophobized antisense oligonucleotides.

Abstract：

:Antisense oligonucleotides were modified by their ends with hydrophobic substituents which permitted enhancing their activity. The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the splicing site 983-994 of early mRNA-5 of the virus and 19-mer complementary to the site of mRNA that encodes the virus DNA-polymerase. These oligonucleotides were modified by 5'-ends with n-undecyl or cholesteryl moieties and by 3'-ends with acridine or 1,7-heptanediol. In comparison with the unmodified oligonucleotides the hydrophobized ones were significantly more active and inhibited HSV-1 infection at micromolar concentrations.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Vinogradov SV,Suzdaltseva Y,Alakhov VYu,Kabanov AV

doi

10.1006/bbrc.1994.2275

subject

Has Abstract

pub_date

1994-09-15 00:00:00

pages

959-66

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X84722753

journal_volume

203

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Bovine adenovirus type 3 internalization is independent of primary receptors of human adenovirus type 5 and porcine adenovirus type 3.

    abstract：:Usefulness of adenoviral vectors derived from human adenovirus (HAd) type 5 (HAd5) is mainly limited by wide prevalence of preexisting anti-HAd5 immunity as well as non-specific tissue tropism of these vectors. As an alternative, non-human adenoviral vectors including bovine adenovirus type 3 (BAd3) are currently bein...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.04.058

    authors： Bangari DS,Sharma A,Mittal SK

    更新日期：2005-06-17 00:00:00

  • Analysis of self-association of West Nile virus capsid protein and the crucial role played by Trp 69 in homodimerization.

    abstract：:The understanding of capsid (C) protein interactions with itself would provide important data on how the core is organized in flaviviruses during assembly. In this study, West Nile (WN) virus C protein was shown to form homodimers using yeast two-hybrid analysis in conjunction with mammalian two-hybrid and in vivo co-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.01.121

    authors： Bhuvanakantham R,Ng ML

    更新日期：2005-04-01 00:00:00

  • Silkworm hemolymph inhibits baculovirus-induced insect cell apoptosis.

    abstract：:The effect of silkworm hemolymph on baculovirus-induced insect cell apoptosis was investigated. The addition of silkworm hemolymph into the culture medium either before or during the baculovirus infection increased the host cell longevity; however, its addition after the infection was less effective. This can be expla...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2592

    authors： Rhee WJ,Park TH

    更新日期：2000-04-29 00:00:00

  • Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.

    abstract：:Epigenetic modifications such as DNA methylation and histone H3 lysine 27 methylation (H3K27me) are repressive marks that silence gene expression. The M phase phosphoprotein (MPP8) associates with proteins involved in both DNA methylation and histone modifications, and therefore, is a potential candidate to mediate cr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.01.122

    authors： Murata K,Sato S,Haruta M,Goshima T,Chiba Y,Takahashi S,Sharif J,Koseki H,Nakanishi M,Shimada M

    更新日期：2015-03-13 00:00:00

  • Inverse expression of two laminin binding proteins, 67LR and galectin-3, correlates with the invasive phenotype of trophoblastic tissue.

    abstract：:Tumor invasion of host tissues and trophoblastic penetration of the endometrium share common biological features. Both processes involve the invasion of basement membranes, an event that is initiated by adhesion of cancer or trophoblast cells to basement membrane components and particularly to laminin. Adhesion to thi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1713

    authors： van den Brûle FA,Price J,Sobel ME,Lambotte R,Castronovo V

    更新日期：1994-05-30 00:00:00

  • Characterization and functional analysis of a novel double-guide C/D box snoRNA in the fission yeast.

    abstract：:Ribose methylation of eukaryotic rRNA is directed by box C/D small nucleolar RNAs (snoRNAs), which pinpoint the nucleotide to be methylated in specific position within the rRNA sequence. Here, we report the identification of a novel double-guide C/D box snoRNA termed snR88 that directs methylation of two previously un...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.207

    authors： Bi YZ,Qu LH,Zhou H

    更新日期：2007-03-02 00:00:00

  • TcRho1 of Trypanosoma cruzi: role in metacyclogenesis and cellular localization.

    abstract：:Here we have investigated the function of TcRho1, a Rho family orthologue from the parasite Trypanosoma cruzi. We have selected parasites overexpressing wild-type TcRho1 and a truncated form of TcRho1 (TcRho1-DeltaCaaX) which is unable to undergo farnesylation and supposed to interfere with recruitment of Rho effector...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.197

    authors： de Melo LD,Nepomuceno-Silva JL,Sant'Anna C,Eisele N,Ferraro RB,Meyer-Fernandes JR,de Souza W,Cunha-e-Silva NL,Lopes UG

    更新日期：2004-10-22 00:00:00

  • Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.

    abstract：:CrkII is an intracellular adaptor protein involved in signal transduction by various growth factors. Activation of PDGF alpha-receptor resulted in its association with CrkII in vivo. In contrast, binding of CrkII to the PDGF beta-receptor was negligible, despite its becoming prominently phosphorylated. Bacterially exp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2374

    authors： Matsumoto T,Yokote K,Take A,Takemoto M,Asaumi S,Hashimoto Y,Matsuda M,Saito Y,Mori S

    更新日期：2000-04-02 00:00:00

  • The SH2 domain containing inositol 5-phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin.

    abstract：:The lipid phosphatase SHIP2 (SH2 domain containing inositol 5-phosphatase 2) has recently been shown to be a potent negative regulator of insulin signaling and insulin sensitivity in vivo. We show here that SHIP2 is expressed in Chinese hamster ovary cells overexpressing the insulin receptor (CHO-IR cells) and tyrosin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4639

    authors： Blero D,De Smedt F,Pesesse X,Paternotte N,Moreau C,Payrastre B,Erneux C

    更新日期：2001-04-06 00:00:00

  • Purification and partial sequencing of human placental alkaline phosphatase.

    abstract：:Two forms of human placental alkaline phosphatase have been purified to homogeneity utilizing high performance liquid chromatography. Both have the same amino acid composition but they differ in their carbohydrate substituents. Sequence data indicate that the two forms are identical for the first forty two residues fr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(83)80252-6

    authors： Ezra E,Blacher R,Udenfriend S

    更新日期：1983-11-15 00:00:00

  • Nanomedicine for the molecular diagnosis of cardiovascular pathologies.

    abstract：:Predicting acute clinical events caused by atherosclerotic plaque rupture remains a clinical challenge. Anatomic mapping of the vascular tree provided by standard imaging technologies is not always sufficient for a robust diagnosis. Yet biological mechanisms leading to unstable plaques have been identified and corresp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2015.06.138

    authors： Juenet M,Varna M,Aid-Launais R,Chauvierre C,Letourneur D

    更新日期：2015-12-18 00:00:00

  • Cbl regulates the activity of SIRT2.

    abstract：:SIRT2 is a member of the sirtuin family of NAD(+)-dependent protein deacetylases. It is involved in metabolic homeostasis and has been linked to the progression of age-related diseases. Casitas B-lineage lymphoma (Cbl) proteins regulate signal transduction through many pathways and, consequently, regulate cell functio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.09.125

    authors： Choi YH,Kim H,Han Y,Jin YH,Lee KY

    更新日期：2014-10-24 00:00:00

  • Proteomic investigations of human HERC2 mutants: Insights into the pathobiology of a neurodevelopmental disorder.

    abstract：:HERC2 is a giant protein with E3 ubiquitin ligase activity and other known and suspected functions. Mutations of HERC2 are implicated in the pathogenesis of various cancers and result in severe neurological conditions in Herc2-mutant mice. Recently, a pleotropic autosomal recessive HERC2-associated syndrome of intelle...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.02.149

    authors： Abraham JR,Barnard J,Wang H,Noritz GH,Yeganeh M,Buhas D,Natowicz MR

    更新日期：2019-04-30 00:00:00

  • Cloning and sequencing of human LH/hCG receptor cDNA.

    abstract：:We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91552-4

    authors： Minegishi T,Nakamura K,Takakura Y,Miyamoto K,Hasegawa Y,Ibuki Y,Igarashi M,Minegish T corrected to Minegishi T

    更新日期：1990-11-15 00:00:00

  • Molecular cloning of anti-SS-A/Ro 60-kDa peptide Fab fragments from infiltrating salivary gland lymphocytes of a patient with Sjögren's syndrome.

    abstract：:Anti-SS-A/Ro antibodies are commonly found in systemic autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus, and some of these antibodies appear to be responsible for certain pathological lesions including congenital heart block in neonatal lupus. In this study, we generated three human anti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6233

    authors： Suzuki H,Takemura H,Suzuki M,Sekine Y,Kashiwagi H

    更新日期：1997-03-06 00:00:00

  • UBE2C promotes the progression of head and neck squamous cell carcinoma.

    abstract：:The development of head and neck squamous cell carcinoma (HNSCC) is a complex pathological process and many cellular and molecular events may occur. The ubiquitin conjugating enzyme E2 (UBE2C) was found to play an oncogenic role in several human cancers. However, its functional role in HNSCC tumorigenesis remains unkn...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.12.064

    authors： Jin Z,Zhao X,Cui L,Xu X,Zhao Y,Younai F,Messadi D,Hu S

    更新日期：2020-03-05 00:00:00

  • INPP4B reverses docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer.

    abstract：:Docetaxel efficiency in the therapy of prostate cancer (PCa) patients is limited due to the development of chemoresistance. Recent studies have implied a role of INPP4B in tumor chemoresistance, while the effects of INPP4B on docetaxel resistance in PCa have not been elucidated. In the present study, the docetaxel-res...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.06.073

    authors： Chen H,Li H,Chen Q

    更新日期：2016-08-26 00:00:00

  • Chondroitin sulfate E blocks enzymatic action of heparanase and heparanase-induced cellular responses.

    abstract：:We examined whether chondroitin sulfates (CSs) exert inhibitory effects on heparanase (Hpse), the sole endoglycosidase that cleaves heparan sulfate (HS) and heparin, which also stimulates chemokine production. Hpse-mediated degradation of HS was suppressed in the presence of glycosaminoglycans derived from a squid car...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.09.126

    authors： Higashi N,Maeda R,Sesoko N,Isono M,Ishikawa S,Tani Y,Takahashi K,Oku T,Higashi K,Onishi S,Nakajima M,Irimura T

    更新日期：2019-11-26 00:00:00

  • Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex.

    abstract：:SMG-9 is a component of the NMD complex, a heterotetramer that also includes SMG-1 and SMG-8 in the complex. SMG-9 was also originally identified as a tyrosine-phosphorylated protein but the role of the phosphorylation is not yet known. In this study, we determined that IQGAP protein, an actin cytoskeleton modifier ac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.099

    authors： Takeda S,Fujimoto A,Yamauchi E,Hiyoshi M,Kido H,Watanabe T,Kaibuchi K,Ohta T,Konishi H

    更新日期：2011-06-24 00:00:00

  • STI-571 inhibits in vitro angiogenesis.

    abstract：:Compounds that block angiogenesis are effective in the treatment of certain cancers and other angiogenesis-related diseases. Many of these compounds specifically target the rapidly proliferating and migrating endothelial cell. However, angiogenesis is a multi-faceted process involving heterotypic interactions between ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.08.129

    authors： Dudley A,Gilbert RE,Thomas D,Cox A,Price JT,Best J,Jenkins A

    更新日期：2003-10-10 00:00:00

  • An endoribonuclease activity associated with Lettre Ehrlich ascites tumor cell mitochondria.

    abstract：:The splicing of 3.36kb mouse mitochondrial mRNA precursor(L-strand) to 69bp RNA component is shown to be mediated by an endoribonuclease activity associated with Lettre Ehrlich ascites tumor cell mitochondria. The enzymic activity was partially purified by column chromatography and the in vitro reconstituted RNA proce...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2214

    authors： Bhattacharya P

    更新日期：1993-10-15 00:00:00

  • IL-6 activates HSP72 gene expression in human skeletal muscle.

    abstract：:To determine whether the cytokine interleukin (IL)-6 induces heat shock protein (HSP) 72 gene expression in skeletal muscle, 18 healthy, young men had either a high dose of IL-6 (HiIL-6; n=6), low dose IL-6 (LoIL-6; n=6), or saline (CON; n=6) infused into one femoral artery for 3h. Muscle biopsies were obtained from t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-291x(02)02079-x

    authors： Febbraio MA,Steensberg A,Fischer CP,Keller C,Hiscock N,Pedersen BK

    更新日期：2002-09-06 00:00:00

  • The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity.

    abstract：:The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identica...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80310-2

    authors： Gullberg U,Widegren B,Arnason U,Egesten A,Olsson I

    更新日期：1986-09-30 00:00:00

  • The nuclear 42-kDa phosphoprotein preferentially binds promoter-containing single-stranded DNA.

    abstract：:The DNA-binding activity of a 42-kDa phosphoprotein from salivary gland cells and cultured epithelial cells of Chironomus tentans have been analyzed by the Southwestern technique. Both the salivary gland and the epithelial cell 42-kDa polypeptides were found to be single-stranded DNA-binding proteins. They bind to sin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90466-k

    authors： Stigare J,Egyhazi E

    更新日期：1991-05-15 00:00:00

  • Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type 1.

    abstract：:Replication of human immunodeficiency virus type 1 (HIV-1) is regulated at reverse transcription. Cellular topoisomerase I has been reported to be carried into HIV-1 virions and enhance cDNA synthesis in vitro, suggesting that topoisomerase I expressed in virus producer cells regulates reverse transcription. Here, by ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00503-X

    authors： Takahashi H,Sawa H,Hasegawa H,Shoya Y,Sata T,Hall WW,Nagashima K,Kurata T

    更新日期：2002-06-07 00:00:00

  • The depletion of interleukin-8 causes cell cycle arrest and increases the efficacy of docetaxel in breast cancer cells.

    abstract：:IL-8 is a multi-functional pro-inflammatory chemokine, which is highly expressed in cancers, such as ER-negative breast cancer. The present study demonstrates the pervasive role of IL-8 in the malignant progression of ER-negative breast cancer. IL-8 siRNA inhibited proliferation and delayed the G1 to S cell cycle prog...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.01.022

    authors： Shao N,Chen LH,Ye RY,Lin Y,Wang SM

    更新日期：2013-02-15 00:00:00

  • Cilostazol induces mitochondrial fatty acid β-oxidation in C2C12 myotubes.

    abstract：:Cilostazol is a drug licensed for the treatment of intermittent claudication. Its main action is to elevate intracellular levels of cyclic monophosphate (cAMP) by inhibiting the activity of type III phosphodiesterase, a cAMP-degrading enzyme. The effects of cilostazol on fatty acid oxidation (FAO) are as yet unknown. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.04.028

    authors： Wang B,Zhu L,Sui S,Sun C,Jiang H,Ren D

    更新日期：2014-05-09 00:00:00

  • Evidence that the long-lifetime photointermediate of s-rhodopsin is a receptor for negative phototaxis in Halobacterium halobium.

    abstract：:The effect of blue background light on behavioral response of Halobacterium halobium to step-like stimulation with green-orange attractant light was examined. The results strongly support the previously proposed hypothesis that a long-lifetime photointermediate of s-rhodopsin is the photoreceptor for repellent light: ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(85)80131-5

    authors： Takahashi T,Mochizuki Y,Kamo N,Kobatake Y

    更新日期：1985-02-28 00:00:00

  • Electrical stimulation induces the level of TGF-beta1 mRNA in osteoblastic cells by a mechanism involving calcium/calmodulin pathway.

    abstract：:It is well-known that electrical stimulation can prompt healing of bone fractures. However, the mechanism involved is less clear. In this study, we found that capacitively coupled electric field-induced proliferation of osteoblastic cells (MC3T3-E1) accompanied increased levels of transforming growth factor-beta 1 (TG...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7118

    authors： Zhuang H,Wang W,Seldes RM,Tahernia AD,Fan H,Brighton CT

    更新日期：1997-08-18 00:00:00

  • IKK regulates the deubiquitinase CYLD at the postsynaptic density.

    abstract：:K63-linked polyubiquitination of proteins regulates their trafficking into specific cellular pathways such as endocytosis and autophagy. CYLD, a deubiquitinase specific for K63-linked polyubiquitins, is present in high quantities at the postsynaptic density (PSD). It was previously shown that, under excitatory conditi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.06.019

    authors： Thein S,Pham A,Bayer KU,Tao-Cheng JH,Dosemeci A

    更新日期：2014-07-18 00:00:00