Abstract:
:In Alzheimer's disease a small fragment of the amyloid protein precursor (APP), called beta 4, is a characteristic component of senile plaques in brains of affected patients. Efforts to intervene in Alzheimer's disease include approaches by which APP levels can be decreased in brain. The study described here demonstrates the expression of APP gene in four cell lines that originated from human brain glioblastomas. In one line, HTB 17, APP mRNA level was approximately 25% the APP mRNA found in human brain and 150% that found in human liver. To ascertain whether or not APP expression in HTB 17 cells could be modulated by a cytokine associated with the inflammatory response, cells were cultured in the presence of IL-1 beta. A significant decrease in APP mRNA accompanied treatment of glioma cells with IL-1 beta.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Yang F,Jansen L,Friedrichs WE,Buchanan JM,Bowman BHdoi
10.1006/bbrc.1993.1318subject
Has Abstractpub_date
1993-03-31 00:00:00pages
1014-9issue
3eissn
0006-291Xissn
1090-2104pii
S0006291X83713185journal_volume
191pub_type
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journal_title:Biochemical and biophysical research communications
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