Abstract:
:We studied the effect of eotaxin, a novel eosinophil-active CC chemokine with high target cell specificity, on human basophils. Eotaxin induced higher levels of chemotactic response with a lower ED50 compared with RANTES in basophils; half-maximal migration occurred at a concentration of approximately 3 nM. On the other hand, it exerted only a marginal effect on either histamine release or leukotriene C4 generation. In addition, nested PCR amplification experiments revealed the expression of CC CKR3, a putative receptor for eotaxin, on basophils. Since accumulation of both basophils and eosinophils is an important aspect of allergic inflammation, eotaxin potentially plays a pathogenic role in allergic disorders by inducing migration of both of these cell types.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Yamada H,Hirai K,Miyamasu M,Iikura M,Misaki Y,Shoji S,Takaishi T,Kasahara T,Morita Y,Ito Kdoi
10.1006/bbrc.1997.6100subject
Has Abstractpub_date
1997-02-13 00:00:00pages
365-8issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(97)96100-3journal_volume
231pub_type
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