Parathyroid hormone-related protein is produced by cultured endothelial cells: a possible role in angiogenesis.

abstract：:L1210/VCR cell line (R) was obtained by adaptation of the L1210 mouse leukaemia cells (S) to vincristine and showed P-glycoprotein (P-gp) mediated multidrug resistance (MDR). R cells were observed to be more sensitive to high external calcium as parental S. More pronounced calcium uptake was observed for R cells. More...

journal_title：Biochemical and biophysical research communications

authors： Sulová Z,Orlický J,Fiala R,Dovinová I,Uhrík B,Seres M,Gibalová L,Breier A

更新日期：2005-09-30 00:00:00

abstract：:The vacuolar proton ATPase (V-ATPase) translocates protons into intracellular organelles or across the plasma membrane of specialised cells such as osteoclast and renal intercalated cells. The catalytic site of the V-ATPase consists of a hexamer of three A subunits and three B subunits which bind and hydrolyse ATP and...

journal_title：Biochemical and biophysical research communications

authors： van Hille B,Vanek M,Richener H,Green JR,Bilbe G

更新日期：1993-11-30 00:00:00

abstract：:The T cell death-associated gene 8 (TDAG8) is a pH-sensing GPCR with a reported immune-specific expression profile. Here, we demonstrate pH-induced activation of TDAG8 receptor cloned from rodent brain (rTDAG8). Cloned rTDAG8 transcript showed 88-95% homology with human and mouse transcripts of lymphoid origin. RT-PCR...

journal_title：Biochemical and biophysical research communications

authors： McGuire J,Herman JP,Ghosal S,Eaton K,Sallee FR,Sah R

更新日期：2009-08-28 00:00:00

abstract：BACKGROUND:Plasma levels of low-density lipoprotein cholesterol (LDL-C) are a major risk factor for cardiovascular disease and are influenced by both heredity and dietary habits. The Niemann-Pick C1 like 1 (NPC1L1) protein mediates efficient dietary cholesterol absorption and contributes to variations in human LDL-C le...

journal_title：Biochemical and biophysical research communications

authors： Yuan Q,Fu Z,Wei J,Li PS,Miao HH,Qu YX,Xu J,Qin J,Li BL,Song BL,Ma Y

更新日期：2016-10-28 00:00:00

abstract：:ABCA1 on the cell surface and in endosomes plays an essential role in the cell-mediated lipidation of apoA-I to form nascent HDL. Our previous studies of transgenic mice overexpressing ABCA1 suggested that ABCA1 in the liver plays a major role in regulating plasma HDL levels. The site of function of ABCA1 in the polar...

journal_title：Biochemical and biophysical research communications

authors： Neufeld EB,Demosky SJ Jr,Stonik JA,Combs C,Remaley AT,Duverger N,Santamarina-Fojo S,Brewer HB Jr

更新日期：2002-10-04 00:00:00

abstract：:In adrenalectomized rats, diacylglycerol, a potent activator of protein kinase C, specifically enhanced the induction of tyrosine aminotransferase and ornithine decarboxylase by even maximally effective doses of dexamethasone phosphate, but itself had no effect on these enzyme inductions in the absence of glucocortico...

journal_title：Biochemical and biophysical research communications

authors： Kido H,Fukusen N,Ishidoh K,Katunuma N

更新日期：1986-07-16 00:00:00

abstract：BACKGROUND:In diabetic retinopathy, prolonged high-level blood glucose induced significant impairments among various retinal tissues, including retinal pigment epithelial (RPE) cells. In an in vitro model of human RPE cells, we evaluated whether 7,8-Dihydroxyflavone (DHF) may effectively prevent high glucose-induced di...

journal_title：Biochemical and biophysical research communications

authors： Yu X,Liu Q,Wang X,Liu H,Wang Y

更新日期：2018-01-01 00:00:00

abstract：:Recently it has been shown that vascular endothelial cells (EC) are completely devoid of apoptosis if cultivated under a steady laminar flow and that apoptosis is induced by turning off the flow. An autocrine loop of thrombospondin-1 (TSP-1) and the alpha(v)beta(3) integrin/integrin-associated protein (IAP) complex ha...

journal_title：Biochemical and biophysical research communications

authors： Freyberg MA,Kaiser D,Graf R,Buttenbender J,Friedl P

更新日期：2001-08-10 00:00:00

abstract：:Simple polyesters derived from poly(ethylene glycol)s and alpha, omega-dicarboxylic acids exhibit a broad range of activity in disrupting phospholipid membranes. This activity has been analyzed by measuring the release of liposome-encapsulated 5(6)-carboxy-fluorescein (CF). Comparison with an analogous monomeric surfa...

journal_title：Biochemical and biophysical research communications

authors： Regen SL,Jayasuriya N,Fabianowski W

更新日期：1989-03-15 00:00:00

abstract：:Through the proteomic analysis using 2-dimensional electrophoresis, the nicotine addiction-associated proteins were extensively screened in the striatum of rat brains. The nicotine addiction was developed by repeated nicotine injection (0.4mg/kg s.c.), twice daily for 7 days, followed by one challenge injection after ...

journal_title：Biochemical and biophysical research communications

authors： Yeom M,Shim I,Lee HJ,Hahm DH

更新日期：2005-01-14 00:00:00

abstract：:A number of bioactive peptides are involved in regulating a wide range of animal behaviors, including food consumption. Vertebrate neuropeptide Y (NPY) is a potent stimulator of appetitive behavior. Recently, Drosophila neuropeptide F (dNPF) and short NPF (sNPF), the Drosophila homologs of the vertebrate NPY, were ide...

journal_title：Biochemical and biophysical research communications

authors： Ida T,Takahashi T,Tominaga H,Sato T,Kume K,Ozaki M,Hiraguchi T,Maeda T,Shiotani H,Terajima S,Sano H,Mori K,Yoshida M,Miyazato M,Kato J,Murakami N,Kangawa K,Kojima M

更新日期：2011-07-15 00:00:00

abstract：:The present study demonstrates that human platelets possess a specific L-arginine transport system able to provide adequate amounts of L-arginine for endogenous nitric oxide production. L-arginine uptake takes place through a saturable high affinity carrier-mediated Na(+)-independent process which is significantly inh...

journal_title：Biochemical and biophysical research communications

authors： Vasta V,Meacci E,Farnararo M,Bruni P

更新日期：1995-01-26 00:00:00

abstract：:Osterix (Osx) is a novel zinc finger-containing transcription factor that is essential for osteoblast differentiation and bone formation in bone homeostasis. The mitogen-activated protein (MAP) kinases are a group of evolutionarily conserved proline-directed protein serine/threonine kinases that are activated in respo...

journal_title：Biochemical and biophysical research communications

authors： Choi YH,Gu YM,Oh JW,Lee KY

更新日期：2011-11-25 00:00:00

abstract：:The calcium-sensing receptor (CaR) is a G protein-coupled receptor that plays key roles in extracellular calcium ion (Ca(2+)(o)) homeostasis by enabling parathyroid, kidney, and other cells to directly "sense" changes in Ca(2+)(o). In multiple myeloma-associated bone disease, myeloma cells could raise the level of Ca(...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Yamauchi M,Sugimoto T,Chauhan D,Anderson KC,Brown EM,Chihara K

更新日期：2002-12-13 00:00:00

abstract：:TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) administered to young male guinea pigs at a dose of 1 microgram/kg (single intraperitoneal injection) caused a large reduction in adipose tissue lipoprotein lipase (LPL) activity. This effect occurred rapidly; a 70% decrease was noticed after 24 hour and 80% of LPL activity w...

journal_title：Biochemical and biophysical research communications

authors： Brewster DW,Matsumura F

更新日期：1984-07-31 00:00:00

abstract：:Previous research showed that protein kinase C alpha (PKC alpha) translocated to the perinuclear region and activated phospholipase D1, but the mechanism involved was not clear. Here, we provide evidence that Phe 663 (the 10th amino acid from C-terminus) of PKC alpha is essential for its translocation. A point mutatio...

journal_title：Biochemical and biophysical research communications

authors： Hu T,Exton JH

更新日期：2005-08-05 00:00:00

abstract：:Primary rat hippocampal neurones show pronounced elevations of intracellular calcium within minutes of exposure to the HIV coat protein gp120. Culture of hippocampal neurones with gp120 causes significant neurotoxicity. We find that the peptide VSLSYRCPCRFF, a competitive inhibitor of the CXCR4 chemokine receptor, mar...

journal_title：Biochemical and biophysical research communications

authors： Pandey V,Bolsover SR

更新日期：2000-07-21 00:00:00

abstract：:The thermal unfolding of myosin in skeletal muscle myofibrils was studied by differential scanning calorimetry (DSC). In the absence of nucleotide two major transitions with Tm of 52 degrees C and 58 degrees C, and a minor transition with Tm of 19 degrees C were detected. The unfolding can be characterized with a tota...

journal_title：Biochemical and biophysical research communications

authors： Lörinczy D,Belagyi J

更新日期：1995-12-14 00:00:00

abstract：:We have developed a novel vector system for the efficient assembly of polydactyl zinc fingers. Next to proteins that possess short canonical TGEKP linkers between all constituting zinc fingers we constructed proteins with longer, 12 amino acid linkers between two three-finger (3F) units and between three two-finger (2...

journal_title：Biochemical and biophysical research communications

authors： Neuteboom LW,Lindhout BI,Saman IL,Hooykaas PJ,van der Zaal BJ

更新日期：2006-01-06 00:00:00

abstract：:Helicobacter pylori releases VacA both as free-soluble and as outer membrane vesicle (OMV)-associated toxin. In this study, we investigated the amount of VacA released in each of the two forms and the role of each form in VacA-induced cell vacuolation in vitro. We found that: (1) free-soluble toxin accounted for about...

journal_title：Biochemical and biophysical research communications

authors： Ricci V,Chiozzi V,Necchi V,Oldani A,Romano M,Solcia E,Ventura U

更新日期：2005-11-11 00:00:00

abstract：:CDX2 is an intestine-specific tumor suppressor gene encoding homeodomain-containing transcription factor, which is involved in a variety of developmental, proliferating, and differentiating processes. Moreover, the expression of CDX2 is reduced in a subset of primary colorectal cancers. In contrast, cyclooxygenase-2 (...

journal_title：Biochemical and biophysical research communications

authors： Kim SP,Park JW,Lee SH,Lim JH,Jang BC,Lee SH,Jang IH,Freund JN,Suh SI,Mun KC,Song DK,Ha EM,Lee WJ,Kwon TK

更新日期：2004-02-27 00:00:00

abstract：:Ghrelin is a peptide found in the hypothalamus and stomach that stimulates food intake and whose circulating concentrations are affected by nutritional state. Very little is known about other central behavioral effects of ghrelin, and thus, we investigated the effects of ghrelin on anxiety and memory retention. The pe...

journal_title：Biochemical and biophysical research communications

authors： Carlini VP,Monzón ME,Varas MM,Cragnolini AB,Schiöth HB,Scimonelli TN,de Barioglio SR

更新日期：2002-12-20 00:00:00

abstract：:Neuroblastoma (NB) expresses the tyrosine kinase receptors c-Kit, PDGFR-alpha and -beta-targets for STI-571. We investigated a possible combination therapy of STI-571 with retinoic acid (RA) and gamma-irradiation on NB cell viability in vitro. Expression of tyrosine kinase receptors and their ligands was examined in 6...

journal_title：Biochemical and biophysical research communications

authors： Rössler J,Zambrzycka I,Lagodny J,Kontny U,Niemeyer CM

更新日期：2006-04-21 00:00:00

abstract：:This paper reports the purification of three myotropic neuropeptides from the white shrimp Penaeus vannamei. The central nervous systems of 3500 shrimps were extracted in an acidified solvent, after which four to five HPLC column systems were used to obtain pure peptides. A cockroach hindgut muscle contraction bioassa...

journal_title：Biochemical and biophysical research communications

authors： Nieto J,Veelaert D,Derua R,Waelkens E,Cerstiaens A,Coast G,Devreese B,Van Beeumen J,Calderon J,De Loof A,Schoofs L

更新日期：1998-07-20 00:00:00

abstract：:Characterization of functional vessels is required either for monitoring hemodynamics or patterning of functional vasculature in experimental models. Haemoglobin (Hb) staining is a traditionally used approach for determining the differentiation of erythroid cells. In this investigation, we tested if HB staining can be...

journal_title：Biochemical and biophysical research communications

authors： Zheng PP,Severijnen LA,Willemsen R,Kros JM

更新日期：2009-03-20 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) is a critical immunosuppressive cytokine that inhibits the cell-mediated immune responses partly via inhibition of immunostimulatory cytokine production from T cells, NK cells, and macrophages. Here we investigated the effect of TGFbeta on NK cell activation induced by interle...

journal_title：Biochemical and biophysical research communications

authors： Hayashi H,Inoue Y,Tsutsui H,Okamura H,Nakanishi K,Onozaki K

更新日期：2003-01-24 00:00:00

abstract：:Based on a homology search with endostatin, the C-terminus 185 aa of collagen XVIII, we report the cloning, expression, and antiangiogenic activity of a 22 kDa human collagen XV fragment, that we have named restin. Restin was expressed in the prokaryotic pET expression system. We have shown that restin inhibits the mi...

journal_title：Biochemical and biophysical research communications

authors： Ramchandran R,Dhanabal M,Volk R,Waterman MJ,Segal M,Lu H,Knebelmann B,Sukhatme VP

更新日期：1999-02-24 00:00:00

abstract：:Oxidative stress plays a key role in the pathogenesis of diabetic nephropathy (DN). The anti-aging protein Klotho has been demonstrated to have antioxidant capacity. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating antioxidant responses. The present study aimed to explore...

journal_title：Biochemical and biophysical research communications

authors： Xing L,Guo H,Meng S,Zhu B,Fang J,Huang J,Chen J,Wang Y,Wang L,Yao X,Wang H

更新日期：2021-01-01 00:00:00

abstract：:Long-term glucocorticoid (GC) usage may cause non-traumatic femoral head osteonecrosis. Dexamethasone (Dex) is shown to exert potent cytotoxic effect to osteoblasts. Here, we investigated the potential activity of α-melanocyte stimulating hormone (α-MSH) against the process. Our data revealed that pretreatment of α-MS...

journal_title：Biochemical and biophysical research communications

authors： Guo S,Xie Y,Fan JB,Ji F,Wang S,Fei H

更新日期：2016-01-08 00:00:00

abstract：:The partitioning of the acylenzyme acetyl-(Gly)n-Phe(NO2)-chymotrypsin (n = 0,1,2) to peptide and peptide acid is observed spectrophotometrically. Values of partitioning ratios for various nucleophiles are calculated from the spectral data. They are a measure for the "true" nucleophile reactivity and are useful in the...

journal_title：Biochemical and biophysical research communications

authors： Petkov DD,Stoineva I

更新日期：1984-01-13 00:00:00