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Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain.

Abstract：

:The T cell death-associated gene 8 (TDAG8) is a pH-sensing GPCR with a reported immune-specific expression profile. Here, we demonstrate pH-induced activation of TDAG8 receptor cloned from rodent brain (rTDAG8). Cloned rTDAG8 transcript showed 88-95% homology with human and mouse transcripts of lymphoid origin. RT-PCR revealed high expression of TDAG8 in forebrain limbic regions. Extracellular acidification induced significantly elevated intracellular cyclic AMP, and phosphorylated CREB in TDAG8 expressing cells. Acidification-induced LDH release was significantly attenuated in cells expressing TDAG8, suggesting neuroprotective potential against acidosis-related cell injury. Our results open up new areas of investigation into the relevance of TDAG8 in pH homeostasis and pathological states associated with acid-base dys-regulation in the brain such as ischemia and panic disorder.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

McGuire J,Herman JP,Ghosal S,Eaton K,Sallee FR,Sah R

doi

10.1016/j.bbrc.2009.05.133

subject

Has Abstract

pub_date

2009-08-28 00:00:00

pages

420-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01116-4

journal_volume

386

pub_type

杂志文章

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