Detection of total DNA with single-stranded DNA binding protein conjugates.

abstract：:Heme oxygenase-1, an essential enzyme in heme catabolism, and metallothionein IIA, a small metal-binding protein with clusters of cysteins, are remarkably induced in HeLa cells following the treatment with cadmium or zinc. Both proteins are considered to be involved in the defense system against metal toxicity. Here w...

journal_title：Biochemical and biophysical research communications

authors： Takeda K,Fujita H,Shibahara S

更新日期：1995-02-06 00:00:00

abstract：:The expansion of a CAG trinucleotide repeat (TNR) sequence has been linked to several neurological disorders, for example, Huntington's disease (HD). In HD, healthy individuals have 5-35 CAG repeats. Those with 36-39 repeats have the premutation allele, which is known to be prone to expansion. In the disease state, gr...

journal_title：Biochemical and biophysical research communications

authors： Jarem DA,Delaney S

更新日期：2011-12-09 00:00:00

abstract：:aDNA extraction and amplification procedures have been optimized for Pompeian human bone remains whose diagenesis has been determined by histological analysis. Single copy genes amplification (X and Y amelogenin loci and Y specific alphoid repeat sequences) have been performed and compared with anthropometric data on ...

journal_title：Biochemical and biophysical research communications

authors： Cipollaro M,Di Bernardo G,Galano G,Galderisi U,Guarino F,Angelini F,Cascino A

更新日期：1998-06-29 00:00:00

abstract：:HMGB proteins are abundant, non-histone proteins in eukaryotic chromatin. HMGB proteins contain one or two conserved "HMG boxes" and can be sequence-specific or nonspecific in their DNA binding. HMGB proteins cause strong DNA bending and bind preferentially to deformed DNAs. We wish to understand how HMGB proteins inc...

journal_title：Biochemical and biophysical research communications

authors： Zimmerman J,Maher LJ 3rd

更新日期：2008-06-20 00:00:00

abstract：:The helix-loop-helix protein Id-1 regulates growth and differentiation in many mammalian cells. In human fibroblasts, Id1 and Id1', a putative splicing variant, are cell cycle regulated, essential for proliferation, repressed by senescence, and overexpressed by some tumor cells. To better understand Id1, we determined...

journal_title：Biochemical and biophysical research communications

authors： Nehlin JO,Hara E,Kuo WL,Collins C,Campisi J

更新日期：1997-02-24 00:00:00

abstract：:31P-NMR spectroscopy of rat liver perchloric acid extracts was utilized to assess the hepatic energy state in an experimental model of chronic dietary iron overload. Oral administration of iron for a period of 65 days that induces a steady ten-fold increase in hepatic iron concentration causes a significant decrease i...

journal_title：Biochemical and biophysical research communications

authors： Ceccarelli D,Predieri G,Muscatello U,Masini A

更新日期：1991-05-15 00:00:00

abstract：:Homo-oligomerization via a coiled-coil (C-C) domain has been shown to be necessary for the promyelocytic leukemia (PML)-retinoic acid receptor-alpha (RARalpha) fusion protein to acquire oncogenic potential in acute promyelocytic leukemia. We show here that PML(DeltaC-C)-RARalpha, which contains a deletion in its C-C d...

journal_title：Biochemical and biophysical research communications

authors： Kim YE,Kim DY,Lee JM,Kim ST,Han TH,Ahn JH

更新日期：2005-05-13 00:00:00

abstract：:TGFbeta is of crucial importance during transdifferentiation of resting retinoid-storing hepatic stellate cells (HSC) to extracellular matrix producing myofibroblasts (MFB) and consequently, inhibition of TGFbeta signal transduction is an effective means for preventing experimental fibrosis. We have shown that isolate...

journal_title：Biochemical and biophysical research communications

authors： Dooley S,Streckert M,Delvoux B,Gressner AM

更新日期：2001-05-11 00:00:00

abstract：BACKGROUND:Numerous previous studies have revealed that many long non-coding RNAs (lncRNAs) are upregulated in gastric cancer (GC) and are associated with tumor onset and progression in GC. ADPGK-AS1, a novel lncRNA, has been discovered as an oncogenic lncRNA in pancreatic cancer while its function in GC remains unclea...

journal_title：Biochemical and biophysical research communications

authors： Huang Z,Yang H

更新日期：2019-05-21 00:00:00

abstract：:Epidemiological data have shown that stress and other psychological factors might influence cancer onset and progression. However, to date, the mechanisms are not well understood. In the present study, we used chronic exposure to a scream as a novel form of sound stress to explore the influence of the chronic stress b...

journal_title：Biochemical and biophysical research communications

authors： Hou N,Zhang X,Zhao L,Zhao X,Li Z,Song T,Huang C

更新日期：2013-10-04 00:00:00

abstract：:The secreted isoform of fibroblast growth factor 3 (FGF3) induces a mitogenic cell response, while the nuclear form inhibits cell proliferation. Recently, we identified a nucleolar FGF3-binding protein which is implicated in processing of pre-rRNA as a possible target of nuclear FGF3 signalling. Here, we report a seco...

journal_title：Biochemical and biophysical research communications

authors： Antoine M,Reimers K,Wirz W,Gressner AM,Müller R,Kiefer P

更新日期：2005-12-16 00:00:00

abstract：:Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and generates the second messenger cyclic GMP (cGMP). Recently, purified sGC α1β1 has been shown to additionally generate the cyclic pyrimidine nucleotides cCMP and cUMP. However, since cyclic pyrimidine nucleotide formation occurred only the presence of...

journal_title：Biochemical and biophysical research communications

authors： Bähre H,Danker KY,Stasch JP,Kaever V,Seifert R

更新日期：2014-01-24 00:00:00

abstract：:The vasculo-toxic effect of meglumine antimoniate (MA) was confirmed in our previous investigation. The current study investigates the association of this effect with altered VEGF-A and VEGF-R2 expression. Additional mechanisms by which MA causes vascular toxicity are not clearly understood. We hypothesized that MA ma...

journal_title：Biochemical and biophysical research communications

authors： Khosravi A,Sharifi I,Tavakkoli H,Keyhani AR,Afgar A,Salari Z,Mosallanejad SS,Bamorovat M,Sharifi F,Hassanzadeh S,Sadeghi B,Dabiri S,Mortazaeizdeh A,Sheikhshoaie Z,Salarkia E

更新日期：2018-11-02 00:00:00

abstract：:Actin bundling protein 34 (ABP34) is the one of 11 actin-crosslinking proteins identified in Dictyostelium discoideum, a novel model organism for the study of actin-associated neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. ABP34 localizes at the leading and trailing edges of locomoto...

journal_title：Biochemical and biophysical research communications

authors： Chung JM,Kim HU,Kim GJ,Jeoung D,Jung HS

更新日期：2018-09-10 00:00:00

abstract：:Retroviral growth requires as an obligatory step the integration of a DNA copy of the viral RNA into the genomic DNA of the host. Recombinant human immunodeficiency virus type I (HIV-1) integrase (IN) expressed in Escherichia coli efficiently catalyzes the overall in vitro integration reaction, namely, the processing ...

journal_title：Biochemical and biophysical research communications

authors： Carteau S,Mouscadet JF,Goulaouic H,Subra F,Auclair C

更新日期：1993-05-14 00:00:00

abstract：:The vasodilator action of organic nitrates is thought to be mediated by an increase in the level of cGMP following stimulation of the cytosolic enzyme guanylate cyclase in the vascular smooth muscle cell. However, direct evidence for the formation of the putative active metabolite, nitric oxide (NO) within the differe...

journal_title：Biochemical and biophysical research communications

authors： Feelisch M,Kelm M

更新日期：1991-10-15 00:00:00

abstract：:Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterized by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses. Genetical heterogeneities have segregated at least on chromosome 8, 11, and 19 and been designated EXT1, EXT2, and EXT3, respectively. R...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Seki N,Yamauchi M,Tsuji S,Hayashi A,Kozuma S,Hori T

更新日期：1998-02-04 00:00:00

abstract：:Insect development is controlled by the combined actions of ecdysteroid and juvenile hormones. Transcriptional control by ecdysteroid hormones is mediated via two nuclear receptor superfamily members, ecdysone receptor (EcR) and its heterodimeric partner, ultraspiracle (USP). Although the ecdysteroid hormone 20-hydrox...

journal_title：Biochemical and biophysical research communications

authors： Maki A,Sawatsubashi S,Ito S,Shirode Y,Suzuki E,Zhao Y,Yamagata K,Kouzmenko A,Takeyama K,Kato S

更新日期：2004-07-16 00:00:00

abstract：:Growing evidence indicates that endoplasmic reticulum (ER) stress and/or ER stress-mediated apoptosis may play a role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease. The present study investigated the effects of non-cytotoxic concentrations of nitric oxide (NO) and nitrite, a metabolite ...

journal_title：Biochemical and biophysical research communications

authors： Jeong SO,Son Y,Lee JH,Choi SW,Kim SH,Cheong YK,Chung HT,Pae HO

更新日期：2017-11-04 00:00:00

abstract：:To characterize mesenchymal stem cells (MSC), we compared gene expression profiles in human bone marrow MSC (11 lines) and human fibroblasts (4 lines) by RT-PCR and real time PCR. Messenger RNA levels of MHC-DR-alpha, MHC-DR-beta, MHC-DR-associated protein CD74, tissue factor pathway inhibitor-2, and neuroserpin were ...

journal_title：Biochemical and biophysical research communications

authors： Ishii M,Koike C,Igarashi A,Yamanaka K,Pan H,Higashi Y,Kawaguchi H,Sugiyama M,Kamata N,Iwata T,Matsubara T,Nakamura K,Kurihara H,Tsuji K,Kato Y

更新日期：2005-06-24 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMSCs) derived from cyanotic congenital heart disease (CCHD) exhibit deficient multi-lineage differentiation potential due to the abnormal accumulation of D-galactose. However, the underlying mechanisms have not yet been explored. Here, the multi-lineage differentiation potential of...

journal_title：Biochemical and biophysical research communications

authors： Wang T,Xing J,Ying Y,Tang H,Li J,Wei Y,Zhang H

更新日期：2020-07-05 00:00:00

abstract：:The multicomponent nature of neuronal plaques in Alzheimer's disease signifies the possible recruitment of non-Aβ candidates during the amyloid growth of Aβ peptides. Here, we show that amyloid fibrils of Aβ1-40 peptide can effectively initiate amyloid formation in different globular proteins and metabolites, converti...

journal_title：Biochemical and biophysical research communications

authors： Anand BG,Prajapati KP,Kar K

更新日期：2018-06-18 00:00:00

abstract：:Potassium tellurite (K(2)TeO(3)) is harmful to most organisms and specific mechanisms explaining its toxicity are not well known to date. We previously reported that the lpdA gene product of the tellurite-resistant environmental isolate Aeromonas caviae ST is involved in the reduction of tellurite to elemental telluri...

journal_title：Biochemical and biophysical research communications

authors： Castro ME,Molina RC,Díaz WA,Pradenas GA,Vásquez CC

更新日期：2009-02-27 00:00:00

abstract：:Telomeres, specialized domains assembled at the ends of linear chromosomes, are essential for genomic stability in eukaryotes. The formation and maintenance of telomeres are governed by numerous factors such as telomeric repeats, telomere-binding proteins, heterochromatin proteins, and telomerase. Here, we report Sde2...

journal_title：Biochemical and biophysical research communications

authors： Sugioka-Sugiyama R,Sugiyama T

更新日期：2011-03-18 00:00:00

abstract：:Gastrin-releasing peptide (GRP) is a neuropeptide that plays roles in various pathophysiological conditions including inflammatory diseases in peripheral tissues; however, little is known about whether GRP can directly regulate endothelial inflammatory processes. In this study, we showed that GRP promotes the adhesion...

journal_title：Biochemical and biophysical research communications

authors： Kim MK,Park HJ,Kim Y,Kim HJ,Bae SK,Bae MK

更新日期：2017-04-01 00:00:00

abstract：:Recently, nanomaterials have been utilized in various fields. In particular, amorphous nanosilica particles are increasingly being used in a range of applications, including cosmetics, food technology, and medical diagnostics. However, there is concern that the unique characteristics of nanomaterials might induce unde...

journal_title：Biochemical and biophysical research communications

authors： Yoshida T,Yoshioka Y,Matsuyama K,Nakazato Y,Tochigi S,Hirai T,Kondoh S,Nagano K,Abe Y,Kamada H,Tsunoda S,Nabeshi H,Yoshikawa T,Tsutsumi Y

更新日期：2012-11-02 00:00:00

abstract：:The neural system appears before the vascular system in the phylogenetic tree. During evolution, vascular system generation takes advantage of the pre-existing vascular endothelial growth factor (VEGF) in order to form its networks. Nevertheless, the role of VEGF in neuronal and glial cells is not yet completely under...

journal_title：Biochemical and biophysical research communications

authors： Fusco MA,Wajsenzon IJ,de Carvalho SL,da Silva RT,Einicker-Lamas M,Cavalcante LA,Allodi S

更新日期：2014-05-02 00:00:00

abstract：:Coenzyme Q10 (CoQ10) protects retinal ganglion cells (RGCs) in experimental retinal ischemia and glaucoma by scavenging reactive oxygen species. We tested whether a diet supplemented with ubiquinol, the reduced form of CoQ10, promotes RGC survival and blocks the apoptotic pathway in ischemic mouse retina induced by ac...

journal_title：Biochemical and biophysical research communications

authors： Ju WK,Shim MS,Kim KY,Bu JH,Park TL,Ahn S,Weinreb RN

更新日期：2018-09-18 00:00:00

abstract：:Hepatitis delta virus (HDV) is a human pathogen causing fulminant hepatitis and liver cirrhosis. HDV has a circular single-stranded RNA genome, which encodes only a single protein, hepatitis delta antigen (HDAg), from the antigenomic strand. Although the functional roles of HDAg have been extensively studied, the mole...

journal_title：Biochemical and biophysical research communications

authors： Hwang SB,Park KJ,Kim YS

更新日期：1998-03-27 00:00:00

abstract：:The p21(WAF-1) promoter contains binding sites for a number of transcription factors which mediate its activation by a variety of external signals. Moreover, it has been reported that the transcription factors involved in p21(WAF-1) activation by certain signaling factors, like the phorbol ester TPA, may vary in diffe...

journal_title：Biochemical and biophysical research communications

authors： Schavinsky-Khrapunsky Y,Huleihel M,Aboud M,Torgeman A

更新日期：2003-05-16 00:00:00