Abstract:
:The neural system appears before the vascular system in the phylogenetic tree. During evolution, vascular system generation takes advantage of the pre-existing vascular endothelial growth factor (VEGF) in order to form its networks. Nevertheless, the role of VEGF in neuronal and glial cells is not yet completely understood. In order to support the hypothesis of a neural role for VEGF, we searched for VEGF- and VEGF receptor (VEGFR)-like immunoreactivities (immunohisto/cytochemistry and Western blotting) in the eyestalk of the invertebrate Ucides cordatus (Crustacea, Brachyura, Ucididae). Our results showed that both neurons and glial cells expressed VEGF-immunoreactivity, and that VEGFR was evidenced in neural cells. This is the first report about the VEGF/VEGFR-like immunoreactivities in the nervous tissue of a crustacean, and enables U. cordatus to be included in the repertoire of animal models used for ascertaining the role of VEGF in the nervous system.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Fusco MA,Wajsenzon IJ,de Carvalho SL,da Silva RT,Einicker-Lamas M,Cavalcante LA,Allodi Sdoi
10.1016/j.bbrc.2014.03.137subject
Has Abstractpub_date
2014-05-02 00:00:00pages
299-303issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(14)00597-Xjournal_volume
447pub_type
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