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CD2AP contributes to cell migration and adhesion in cultured gastric epithelium.

Abstract：

:The potential association of CD2AP with the adherens junction protein E-cadherin, co-localization with the actin cytoskeleton, and involvement in cell migration was investigated in cultured rat gastric mucosal cells. In stationary cells, CD2AP was localized perinuclearly while E-cadherin was expressed along cell-cell contacts and F-actin formed a branched network and adhesion belts. In migrating cells, CD2AP appeared as thread-like accumulations in the leading edges, colocalizing with F-actin and occasionally with E-cadherin. Intracellular injection of anti-CD2AP significantly retarded the migration speed of the cells suggesting a crucial role for CD2AP in mucosal cell migration, possibly as a scaffolding protein between cell membrane proteins and actin cytoskeleton. Co-immunoprecipitation assays revealed that CD2AP and E-cadherin are in a complex in HGF stimulated cells. It is concluded that CD2AP interacts with E-cadherin and co-localizes with F-actin in the leading edge of migrating cells, and significantly contributes to cell migration in restituting gastric epithelium.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mustonen H,Lepistö A,Lehtonen S,Lehtonen E,Puolakkainen P,Kivilaakso E

doi

10.1016/j.bbrc.2005.04.140

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

426-32

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00922-8

journal_volume

332

pub_type

杂志文章

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