The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling.

Abstract:

:Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) and its role in IGF-1-induced cardiac hypertrophy. We found that IGF-1 addition to cultured rat cardiomyocytes activated MEF2C, as evidenced by its increased nuclear localization and DNA binding activity. IGF-1 stimulated MEF2 dependent-gene transcription in a time-dependent manner, as indicated by increased MEF2 promoter-driven reporter gene activity; IGF-1 also induced p38-MAPK phosphorylation, while an inhibitor of p38-MAPK decreased both effects. Additionally, inhibitors of phosphatidylinositol 3-kinase and calcineurin prevented IGF-1-induced MEF2 transcriptional activity. Via MEF2C-dependent signaling, IGF-1 also stimulated transcription of atrial natriuretic factor and skeletal alpha-actin but not of fos-lux reporter genes. These novel data suggest that MEF2C activation by IGF-1 mediates the pro-hypertrophic effects of IGF-1 on cardiac gene expression.

authors

Muñoz JP,Collao A,Chiong M,Maldonado C,Adasme T,Carrasco L,Ocaranza P,Bravo R,Gonzalez L,Díaz-Araya G,Hidalgo C,Lavandero S

doi

10.1016/j.bbrc.2009.07.147

subject

Has Abstract

pub_date

2009-10-09 00:00:00

pages

155-60

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01514-9

journal_volume

388

pub_type

杂志文章
  • SPTLC1 inhibits cell growth via modulating Akt/FOXO1 pathway in renal cell carcinoma cells.

    abstract::Serine palmitoyltransferase long chain-1 (SPTLC1), which is the rate-limiting enzyme for sphingolipid biosynthesis, has been indicated to be essential for carcinoma cell survival and proliferation in recent, but its role in the regulation of renal cell carcinoma (RCC) remains unknown. In the present study, we found th...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2019.09.073

    authors: Kong Z,Guo X,Zhao Z,Wu W,Luo L,Zhu Z,Yin S,Cai C,Wu W,Wang D,Liu Y,Duan X

    更新日期:2019-11-26 00:00:00

  • An in-depth analysis of the biological functional studies based on the NMR M2 channel structure of influenza A virus.

    abstract::The long-sought three-dimensional structure of the M2 proton channel of influenza A virus was successfully determined recently by the high-resolution NMR [J.R. Schnell, J.J. Chou, Structure and mechanism of the M2 proton channel of influenza A virus, Nature 451 (2008) 591-595]. Such a milestone work has provided a sol...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.10.148

    authors: Huang RB,Du QS,Wang CH,Chou KC

    更新日期:2008-12-26 00:00:00

  • Hunt for singlet oxygen under in vivo conditions.

    abstract::It is widely accepted that applying exogenous photosensitizers in living organism the photodynamic effect is mediated by singlet oxygen formed by energy transfer from excited sensitizer to oxygen present in the cells (Type II mechanism). Though in homogeneous solutions singlet oxygen was detected during sensitization,...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1994.1886

    authors: Gál D

    更新日期:1994-07-15 00:00:00

  • Activation of bovine photoreceptor guanylate cyclase by S100 proteins.

    abstract::S100 proteins are acidic calcium-binding proteins present in high concentration in the brain and at lower concentrations in peripheral tissues. Their function remains to be elucidated in many tissues. In this report we show for the first time that S100 proteins stimulate the bovine photoreceptor membrane guanylate cyc...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1996.0043

    authors: Margulis A,Pozdnyakov N,Sitaramayya A

    更新日期:1996-01-05 00:00:00

  • The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse.

    abstract::We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively charged liposomes were cleared at identical rates in apoE-deficient and wild-type mice; neutral liposomes were cleared at a 3.6-fold slower rate in apoE-defici...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2004.12.137

    authors: Yan X,Kuipers F,Havekes LM,Havinga R,Dontje B,Poelstra K,Scherphof GL,Kamps JA

    更新日期:2005-03-04 00:00:00

  • Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.

    abstract::During screening for the flavonoid chemosensitizers, it was found that 5,7,3',4',5'-pentamethoxyflavone (PMF) was equipotent to verapamil in vitro with respect to the chemosensitizing effect. PMF appears to have a chemosensitizing effect not only by increasing the intracellular accumulation of the drugs without compet...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2004.06.020

    authors: Choi CH,Kim JH,Kim SH

    更新日期:2004-07-30 00:00:00

  • A comparison of substrate dynamics in human CYP2E1 and CYP2A6.

    abstract::Considering the dynamic nature of CYPs, methods that reveal information about substrate and enzyme dynamics are necessary to generate predictive models. To compare substrate dynamics in CYP2E1 and CYP2A6, intramolecular isotope effect experiments were conducted, using deuterium labeled substrates: o-xylene, m-xylene, ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.11.071

    authors: Harrelson JP,Henne KR,Alonso DO,Nelson SD

    更新日期:2007-01-26 00:00:00

  • c-myc gene expression in human cells is controlled by glucose.

    abstract::The c-myc oncogene is implicated in normal growth and differentiation processes. Human cell lines IM9 and HepG2 stably cultured at "low" glucose concentrations (5.5 mM) show c-myc mRNA levels 3-4 times higher than cells cultured at "high" glucose concentrations (25 nM). D-fructose (a metabolizable exose) substitutes f...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(89)92719-8

    authors: Briata P,Laurino C,Gherzi R

    更新日期:1989-12-29 00:00:00

  • Erythrocyte membrane nanoparticles improve the intestinal absorption of paclitaxel.

    abstract::Paclitaxel (PTX) is a cytotoxic chemotherapy drug with encouraging activity in human malignancies. However, free PTX has a very low oral bioavailability due to its low aqueous solubility and the gastrointestinal drug barrier. In order to overcome this obstacle, we have designed erythrocyte membrane nanoparticles (EMNP...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2017.05.042

    authors: Jiang X,Wang K,Zhou Z,Zhang Y,Sha H,Xu Q,Wu J,Wang J,Wu J,Hu Y,Liu B

    更新日期:2017-06-24 00:00:00

  • UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma.

    abstract::Ubiquitin-conjugating enzyme E2S (UBE2S) plays pivotal roles in the progression of human cancers. However, its clinical significance and role in hepatocellular carcinoma (HCC) remain unknown. Here, we show that UBE2S is upregulated in HCC and exhibits oncogenic activities via enhancing the ubiquitination of p53. Incre...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.06.093

    authors: Pan YH,Yang M,Liu LP,Wu DC,Li MY,Su SG

    更新日期:2018-09-05 00:00:00

  • Monoterpenoid perillyl alcohol impairs metabolic flexibility of Candida albicans by inhibiting glyoxylate cycle.

    abstract::The metabolic pathway such as glyoxylate cycle (GC) enables Candida albicans, to survive under glucose deficient conditions prevalent in the hostile niche. Thus its key enzymes (Isocitrate lyase; ICL and malate synthase; MLS) represent attractive targets against C. albicans. We have previously reported the antifungal ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2017.11.064

    authors: Ansari MA,Fatima Z,Ahmad K,Hameed S

    更新日期:2018-01-01 00:00:00

  • Adiponectin differentially regulates cytokines in porcine macrophages.

    abstract::Adiponectin, an adipocyte-derived hormone, attenuates the production of TNFalpha by activated human macrophages. In the present study, we used porcine blood-derived macrophages to test the hypothesis that the anti-inflammatory action of adiponectin includes suppression of IL6 and an induction of IL10. Adiponectin supp...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2004.02.130

    authors: Wulster-Radcliffe MC,Ajuwon KM,Wang J,Christian JA,Spurlock ME

    更新日期:2004-04-09 00:00:00

  • Fast atom bombardment: evidence of disproportionation and recombination of a synthetic porphyrin in the matrix.

    abstract::In addition to dimerization and polymerization of samples as previously suggested, it appears that during FAB-MS, reactions in the sample matrix can occur to yield new compounds that are recombinations of molecular fragments. This type of reaction may be especially critical to the integrity of peptide sequencing using...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(83)90331-5

    authors: Kurlansik L,Williams TJ,Campana JE,Green BN,Anderson LW,Strong JM

    更新日期:1983-03-16 00:00:00

  • Suppression of HPV E6 and E7 expression by BAF53 depletion in cervical cancer cells.

    abstract::Deregulation of the expression of human papillomavirus (HPV) oncogenes E6 and E7 plays a pivotal role in cervical carcinogenesis because the E6 and E7 proteins neutralize p53 and Rb tumor suppressor pathways, respectively. In approximately 90% of all cervical carcinomas, HPVs are found to be integrated into the host g...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2011.07.098

    authors: Lee K,Lee AY,Kwon YK,Kwon H

    更新日期:2011-08-26 00:00:00

  • High- and low-affinity CCKA receptor states mediate specific growth inhibitory effects on CHO cells.

    abstract::To relate specific effects on growth and transformation to activation of specific affinity states of the CCKA receptor stably expressed in CHO cells we compared responses to the CCK analogues JMV-180 and CCK8. CCK8 led to an inhibition of both cell proliferation and transformation. Effects on proliferation were indica...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1995.2096

    authors: Detjen K,Tseng MJ,Logsdon CD

    更新日期:1995-08-04 00:00:00

  • Correlation between up-regulation of lymphokine mRNA and down-regulation of TcR, CD4, CD8 and lck mRNA as shown by the effect of CsA on activated T lymphocytes.

    abstract::Full activation of different T cell populations via the TcR/CD3 complex leads to transient expression of lymphokine mRNA and to transient and specific down-modulation of TcR, CD4, CD8 and p56lck mRNA (Multi-Receptor Complex or MRC mRNA). This transient down-modulation is due to both a decrease in transcription and sta...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(92)90789-n

    authors: Paillard F,Sterkers G,Vaquero C

    更新日期:1992-07-31 00:00:00

  • Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages.

    abstract::Studies of islet neogenesis have suggested that the regeneration of islet cells can be achieved through redifferentiation of pre-existing islet cells. However, this hypothesis is largely unproven and fails to account for the diversity of observed islet neogenesis. Here we show that cultured neonatal pancreatic cells d...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.10.179

    authors: Zhao W,Hirose T,Ishikawa M,Oshima Y,Hirai S,Ohno S,Taniguchi H

    更新日期:2007-01-05 00:00:00

  • hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo.

    abstract::Recent work identified an RNA binding protein whose presence in brain tumors correlated with translational repression of Glut1 expression. RNase T1 mapping demonstrated that this protein bound an AU-rich response element (AURE) in the Glut1 3'UTR. Facilitated by its differential expression in brain tumor cytosols, we ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1999.1040

    authors: Hamilton BJ,Nichols RC,Tsukamoto H,Boado RJ,Pardridge WM,Rigby WF

    更新日期:1999-08-11 00:00:00

  • Effect of siderophores, catecholamines, and catechol compounds on Listeria spp. Growth in iron-complexed medium.

    abstract::Almost all bacteria require iron for growth and virulence expression. However, Listeria spp. do not produce any siderophore for iron acquisition. Representative strains of each of the six species of Listeria were examined for their ability to use various compounds as iron suppliers in iron-restricted medium. Here we s...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.9184

    authors: Coulanges V,Andre P,Vidon DJ

    更新日期:1998-08-19 00:00:00

  • Developmentally regulated expression of a nonmuscle myosin heavy chain IIB inserted isoform in rat brain.

    abstract::The alternatively spliced isoform of the nonmuscle myosin II heavy chain B (MHC-B) with an insert of 21 amino acids at the 50- to 20-kDa junction of the globular region of myosin has been demonstrated to be expressed specifically in the central nervous system (CNS) in chicken. To explore the role of this B2 inserted i...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1999.0717

    authors: Takahashi M,Hirano T,Uchida K,Yamagishi A

    更新日期:1999-05-27 00:00:00

  • The human prothrombin kringle-2 derived peptide, NSA9, is internalized into bovine capillary endothelial cells through endocytosis and energy-dependent pathways.

    abstract::Human prothrombin kringle-2 and its partial peptide, NSA9 (NSAVQLVEN), have been reported to have potent anti-angiogenic activities. Here, the internalization mechanism of NSA9 into bovine capillary endothelial (BCE) cells was examined using lactate dehydrogenase (LDH) release assay, fluorescence microscopy, and flow ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.07.090

    authors: Hwang HS,Kim SS

    更新日期:2005-09-23 00:00:00

  • A novel murine PDGF-D splicing variant results in significant differences in peptide expression and function.

    abstract::Platelet-derived growth factor (PDGF) is a potent mesenchymal cell mitogen and chemoattractant involved in the pathogenesis of fibroproliferative diseases. There are four known PDGF ligand isoforms designated A-D, two of which, C and D, were only recently discovered. We have identified a splicing variant in the PDGF-D...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(03)01346-9

    authors: Zhuo Y,Hoyle GW,Zhang J,Morris G,Lasky JA

    更新日期:2003-08-15 00:00:00

  • Ras/MEK pathway is required for NGF-induced expression of tyrosine hydroxylase gene.

    abstract::Neurotrophins are essential for the development and survival of catecholaminergic neurons. However, the critical pathway for expression of the tyrosine hydroxylase (TH) gene induced by neurotrophin is still unclear. Here we found that Ras/MEK pathway is required for NGF-induced expression of the TH gene in PC12D cells...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2004.01.068

    authors: Suzuki T,Kurahashi H,Ichinose H

    更新日期:2004-03-05 00:00:00

  • Gangliosides and chondroitin sulfate desensitize and internalize B2 bradykinin receptors.

    abstract::Prolonged or repeated agonist activation of G-protein-coupled receptors (GPCRs) initiates their desensitization and internalization, rendering them unresponsive to agonist activation. We analyzed how gangliosides and chondroitin sulfate affect B2 bradykinin (BK) receptors (B2Rs). Gangliosides and chondroitin sulfate d...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2012.02.142

    authors: Shimazaki A,Nakagawa T,Mitoma J,Higashi H

    更新日期:2012-03-30 00:00:00

  • MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway.

    abstract::Discerning oncogenic drivers from passengers remains a major effort in understanding of the essence of the initiation and development of hepatocellular carcinoma (HCC), the most common primary liver malignancy and the third leading cause of cancer mortality worldwide. Here we report that MTA2, Metastasis Associated 1 ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2019.05.025

    authors: Guan C,Chang Z,Gu X,Liu R

    更新日期:2019-07-12 00:00:00

  • Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells.

    abstract::The membrane electroporation-induced inward current (IMEP) in pituitary tumor (GH3) cells was characterized. This current emerges irregularly when membrane hyperpolarizations to -200 mV with a holding potential of -80 mV were elicited. Neither E-4031 (10 μM), glibenclamide (30 μM), nor ZD7288 (30 μM) caused any effect...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2011.01.066

    authors: Wu SN,Huang HC,Yeh CC,Yang WH,Lo YC

    更新日期:2011-02-18 00:00:00

  • Thromboxane A2 receptor linked with the Ca2+ pathway in rat colonic crypt cells.

    abstract::To clarify the presence of thromboxane A2 (TXA2) receptor in the colonic epithelium, we examined the effect of 9,11-epithio-11, 12-methano-thromboxane A2 (STA2), a stable analogue of TXA2, on intracellular free Ca2+ concentration ([Ca2+]i) of indo-1-loaded single cells in isolated rat colonic crypts by laser confocal ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1999.0674

    authors: Ikari A,Sakai H,Sato T,Takeguchi N

    更新日期:1999-05-19 00:00:00

  • Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells.

    abstract::G-protein-coupled receptor 120 (GPR120) and GPR40 exhibit a variety of biological responses by the binding of free fatty acids. 12-O-Tetradecanoylphorbol-13-acetate (TPA) is a tumor promoting agent of skin carcinogenesis. It is known that TPA treatment stimulates cell motile activity of cancer cells, including melanom...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2016.05.023

    authors: Fukushima K,Takahashi K,Fukushima N,Honoki K,Tsujiuchi T

    更新日期:2016-06-17 00:00:00

  • Proteolipidic vectors for gene transfer to the lung.

    abstract::In order to develop improved synthetic gene transfer vectors, we have synthesized bifunctional peptides composed of a DNA binding peptide (P2) and ligand peptides selected by the phage display technique on tracheal epithelial cells. We have evaluated the capacity of these peptides to enhance the gene transfer efficien...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.2002.6343

    authors: Vaysse L,Guillaume C,Burgelin I,Gorry P,Férec C,Arveiler B

    更新日期:2002-02-08 00:00:00

  • Diglyceride/monoglyceride lipases pathway is not essential for arachidonate release in thrombin-activated human platelets.

    abstract::Human platelets prelabeled with arachidonate exhibited a rapid and transient rise in arachidonoyl monoglyceride in addition to arachidonoyl diglyceride following thrombin stimulation. Substantial release of arachidonate and its metabolites also occurred at the early phase. Preincubation of labeled platelets with RHC 8...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(83)90457-6

    authors: Chau LY,Tai HH

    更新日期:1983-05-31 00:00:00