Structural and functional analyses of the lipase CinB from Enterobacter asburiae.

abstract：:In the brains of Alzheimer's disease patients, the tau protein abnormally aggregates to form an insoluble paired helical filament (PHF). Since the third repeat structure (R3) of the tau microtubule-binding domain plays an essential role in PHF formation and self-aggregates most significantly in an aqueous solution of ...

journal_title：Biochemical and biophysical research communications

authors： Minoura K,Mizushima F,Tokimasa M,Hiraoka S,Tomoo K,Sumida M,Taniguchi T,Ishida T

更新日期：2005-02-25 00:00:00

abstract：:Oncogenes c-myc, H-ras, c-fos and erb-B were constitutively expressed in immature chick oviduct withdrawn from estrogen administration for 2.5 weeks after 10 d of primary estrogen stimulation. Following secondary estrogen stimulation of the withdrawn chicks, synthesis of egg white proteins is rapidly induced and remai...

journal_title：Biochemical and biophysical research communications

authors： Cohrs RJ,Goswami BB,Sharma OK

更新日期：1988-01-15 00:00:00

abstract：:Lipoprotein (a) [Lp(a)], a risk factor for coronary artery disease, is a LDL-like particle with apolipoprotein (a) [apo(a)] covalently linked to apolipoprotein B (apoB). Apo(a) has many repeats of kringle 4-like domain, classified as type 1 through type 10 (T1-T10). Deletion analysis was performed to define the functi...

journal_title：Biochemical and biophysical research communications

authors： Trieu VN,McConathy WJ

更新日期：1998-10-09 00:00:00

abstract：:Human embryonic stem cells (hESCs) are thought to be a promising cell source for cell transplantation therapy. For such a clinical application, the hESCs should be manipulated using appropriate and qualified materials. In this study, we examined the efficacy of recombinant human laminin (rhLM) isoforms on the undiffer...

journal_title：Biochemical and biophysical research communications

authors： Miyazaki T,Futaki S,Hasegawa K,Kawasaki M,Sanzen N,Hayashi M,Kawase E,Sekiguchi K,Nakatsuji N,Suemori H

更新日期：2008-10-10 00:00:00

abstract：:Aerobic incubation of rat spermatozoa in a balanced salt solution containing 10 microM of gossypol produced a loss of sperm motility. This effect was not reverted by the presence of 25 mM Theophylline, a well-known stimulant of motility, but was significantly diminished by the addition of 10 mM Mannitol. As mannitol i...

journal_title：Biochemical and biophysical research communications

authors： Fornés MW,Barbieri AM,Burgos MH

更新日期：1993-09-30 00:00:00

abstract：:The increasingly appreciated role of astrocytes in neurophysiology dictates a thorough understanding of the mechanisms underlying the communication between astrocytes and neurons. In particular, the uptake and release of signaling substances into/from astrocytes is considered as crucial. The release of different gliot...

journal_title：Biochemical and biophysical research communications

authors： Potokar M,Kreft M,Lee SY,Takano H,Haydon PG,Zorec R

更新日期：2009-12-25 00:00:00

abstract：:One hypothesis for the etiology of Parkinson's disease (PD) is that the formation of proteinaceous inclusion, which is mainly composed of alpha-synuclein, may contribute to the selective loss of dopaminergic neurons. To further explore the role of alpha-synuclein in neurodegeneration of PD, we examined the possible ef...

journal_title：Biochemical and biophysical research communications

authors： Yu F,Xu H,Zhuo M,Sun L,Dong A,Liu X

更新日期：2005-05-27 00:00:00

abstract：:Two isoforms of the src-family tyrosine kinase p59fyn have been shown to arise through alternative splicing of exon 7 of the fyn gene. These isoforms have been designated fynT, expressed in hematopoietic cells, and fynB, expressed in the brain. Here, we describe a novel isoform, fynDelta7, in which exon 7 is absent. F...

journal_title：Biochemical and biophysical research communications

authors： Goldsmith JF,Hall CG,Atkinson TP

更新日期：2002-11-08 00:00:00

abstract：:N-Palmitoyl-(S)-seryl-(S)-seryl-(S)-asparaginyl-(S)-alanine (Palmitoyl-tetrapeptide) is an analogue of the N-terminal part of the lipoprotein from the outer membrane of Escherichia coli. It was prepared by chemical synthesis and tested for biological activity in in vitro lymphocyte culture systems. In spleen cells of ...

journal_title：Biochemical and biophysical research communications

authors： Bessler WG,Cox M,Wiesmüller KH,Jung G

更新日期：1984-05-31 00:00:00

abstract：:High circulating levels of anti-endothelial antibodies have been reported in patients with accelerated transplant coronary artery disease (TxCAD); however, the nature or characteristics of the antigen to which these antibodies bind in vivo remain unclear. To identify the antigen, a human endothelial cell cDNA expressi...

journal_title：Biochemical and biophysical research communications

authors： Ationu A,Collins A

更新日期：1997-07-30 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA poly...

journal_title：Biochemical and biophysical research communications

authors： Jin Z,Wang H,Duan Y,Yang H

更新日期：2020-11-21 00:00:00

abstract：:The Fas/FasL signaling pathway, controlled by nuclear factor-κB (NFκB) at the transcriptional level, is critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell (SC) injury, but the exact regulation mechanism remain unknown. Here, we discovered that expressio...

journal_title：Biochemical and biophysical research communications

authors： Chen S,Dong Y,Xu C,Jiang L,Chen Y,Jiang C,Hou W,Li W

更新日期：2013-11-01 00:00:00

abstract：:The peroxidative activation of the antitumor drugs, etoposide (VP-16) and teniposide (VM-26), has been studied in vitro. Both of these drugs, in the presence of horseradish peroxidase or prostaglandin synthetase, formed phenoxy radical intermediates. Furthermore, this activation also resulted in the formation of two m...

journal_title：Biochemical and biophysical research communications

authors： Haim N,Roman J,Nemec J,Sinha BK

更新日期：1986-02-26 00:00:00

abstract：:Normal human fibroblasts stop dividing after a limited number of cell divisions termed cellular senescence. Telomere shortening has been shown to be the main factor that causes cellular senescence, however, the molecular mechanism of how telomere shortening causes cellular senescence is unclear. Here we analyze the re...

journal_title：Biochemical and biophysical research communications

authors： Chen HL,Lu CY,Hsu YH,Lin JJ

更新日期：2004-01-16 00:00:00

abstract：:Cytoplasmic dyneins are multisubunit minus-end-directed microtubule motors. Different isoforms of dynein are thought to provide a means for independent movement of different organelles. We investigated the differential regulation of dynein-driven transport of pigment organelles (melanosomes) in Xenopus melanophores. A...

journal_title：Biochemical and biophysical research communications

authors： Reilein AR,Serpinskaya AS,Karcher RL,Dujardin DL,Vallee RB,Gelfand VI

更新日期：2003-09-26 00:00:00

abstract：:Kinase suppressor of ras (KSR) and MEKK3 (MAP kinase kinase kinase) are integral members of the MAP kinase pathway. We have recently identified a new isoform of the KSR family named human kinase suppressor of ras-2 (hKSR-2), and demonstrated that hKSR-2 negatively regulates Cot, a MAP3K family member which is importan...

journal_title：Biochemical and biophysical research communications

authors： Channavajhala PL,Rao VR,Spaulding V,Lin LL,Zhang YG

更新日期：2005-09-09 00:00:00

abstract：:The P-type ATPases affected in Menkes and Wilson diseases, ATP7A and ATP7B, respectively, are key copper transporters that regulate copper homeostasis. The N termini of these proteins are critical in regulating their function and activity, and contain six copper-binding motifs MxCxxC. In this study, we describe the id...

journal_title：Biochemical and biophysical research communications

authors： Lim CM,Cater MA,Mercer JF,La Fontaine S

更新日期：2006-09-22 00:00:00

abstract：:RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases that can dephosphorylate both Ser2-PO(4) and Ser5-PO(4) of CTD have been identified in animals and yeasts, however, only Ser5-PO(4)-specific CTD phosphatases have been identified in plants. Among predicted Arabidopsis SCP1-like small phosphatases (SS...

journal_title：Biochemical and biophysical research communications

authors： Feng Y,Kang JS,Kim S,Yun DJ,Lee SY,Bahk JD,Koiwa H

更新日期：2010-06-25 00:00:00

abstract：:Inhibition experiments with D-mannose oligosaccharides establish that conglutinin recognises terminal alpha 1----2 mannobiosyl units present in the glycopeptide of the alpha-chain of the complement component C3b. On the basis of its three domain structure and the homology of its N-terminal amino-acid sequence to that ...

journal_title：Biochemical and biophysical research communications

authors： Young NM,Leon MA

更新日期：1987-03-13 00:00:00

abstract：:We established a simple and highly efficient method for in vivo gene transfer using HVJ (Sendai virus) and liposomes. Plasmid DNA and high mobility group 1 (HMG1) protein were co-encapsulated in liposomes by agitation and sonication and were co-introduced into cells by HVJ-mediated membrane fusion. pACT SVT DNA, as a ...

journal_title：Biochemical and biophysical research communications

authors： Tomita N,Higaki J,Morishita R,Kato K,Mikami H,Kaneda Y,Ogihara T

更新日期：1992-07-15 00:00:00

abstract：:We isolated and sequenced a cDNA clone corresponding to the entire coding sequence of rat liver lysosomal cathepsin D. The deduced amino acid sequence revealed that cathepsin D consists of 407 amino acid residues (Mr 44,608) and the 20 NH2-terminal residues seem to constitute a cleavable signal peptide after which 44 ...

journal_title：Biochemical and biophysical research communications

authors： Fujita H,Tanaka Y,Noguchi Y,Kono A,Himeno M,Kato K

更新日期：1991-08-30 00:00:00

abstract：:Narcan, the pharmaceutical agent for the administration of naloxone, has been reported to antagonize ethanol intoxication. In addition to naloxone, Narcan contains the antioxidant esters methyl- and propylparaben. Pure naloxone and these two esters were examined for their capacity to inhibit ethanol oxidation by purif...

journal_title：Biochemical and biophysical research communications

authors： Dingley AL,Holmquist B,Vallee BL

更新日期：1985-08-30 00:00:00

abstract：:Activities of the hepadnavirus polymerases are known to include those of DNA polymerase, reverse transcriptase and RNase H. To date, it has been difficult or impossible to clone and express the product as an active enzyme. In this study, full length capped RNA encoding Duck Hepatitis B Virus (DHBV) polymerase was prod...

journal_title：Biochemical and biophysical research communications

authors： Howe AY,Elliott JF,Tyrrell DL

更新日期：1992-12-15 00:00:00

abstract：:Akt/PKB plays a pivotal role in cell survival and proliferation. Previously, we reported that UV-irradiation induces extensive cell death in Akt2(-/-) mouse embryonic fibroblasts (MEFs) while Akt1(-/-) MEFs show cell cycle arrest. Here, we find that Akt1(-/-) MEFs exhibit phenotypic changes characteristics of senescen...

journal_title：Biochemical and biophysical research communications

authors： Jee HJ,Kim HJ,Kim AJ,Bae YS,Bae SS,Yun J

更新日期：2009-06-05 00:00:00

abstract：:The 3'UTR of eukaryotic mRNA is an important regulation region, on which many trans factors act. In recent years, a series of 3'UTRs were shown to have tumor suppressor function, including the 3'UTR of the human nuclear factor for interleukin-6 (NF-IL6 3'UTR). To understand molecular basis for this function, we have t...

journal_title：Biochemical and biophysical research communications

authors： He YZ,Liu DG

更新日期：2000-09-16 00:00:00

abstract：:We previously reported that fucoidan, a dietary fiber purified from seaweed, inhibited IgE production by B cells in vitro. In this study, we examined the effect of fucoidan on IgE production in vivo. The OVA-induced increase of plasma IgE was significantly suppressed when fucoidan was intraperitoneally, but not orally...

journal_title：Biochemical and biophysical research communications

authors： Yanase Y,Hiragun T,Uchida K,Ishii K,Oomizu S,Suzuki H,Mihara S,Iwamoto K,Matsuo H,Onishi N,Kameyoshi Y,Hide M

更新日期：2009-09-25 00:00:00

abstract：:The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). ...

journal_title：Biochemical and biophysical research communications

authors： Liu F,You X,Chi X,Wang T,Ye L,Niu J,Zhang X

更新日期：2014-02-07 00:00:00

abstract：:The formation of nitric oxide in biological systems has led to the discovery of a number of post-translational protein modifications that could regulate protein function or potentially be utilized as transducers of nitric oxide signaling. Principal among the nitric oxide-mediated protein modifications are: the nitric ...

journal_title：Biochemical and biophysical research communications

authors： Ischiropoulos H

更新日期：2003-06-06 00:00:00

abstract：:Despite the mitochondria ubiquitous nature many of their components display divergences in their expression profile across different tissues. Using the bioinformatics-approach of guilt by association (GBA) we exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coi...

journal_title：Biochemical and biophysical research communications

authors： Martherus RS,Sluiter W,Timmer ED,VanHerle SJ,Smeets HJ,Ayoubi TA

更新日期：2010-11-12 00:00:00

abstract：:The Mr approximately equal to 90,000 heat shock protein, hsp90, readily interacts with the glucocorticoid receptor to form the 9 S, non-DNA-binding receptor complex. This receptor is stabilized in cytosolic preparations by sodium molybdate. In analogy, sodium molybdate stabilizes a 9 S form of the dioxin receptor. Pol...

journal_title：Biochemical and biophysical research communications

authors： Denis M,Cuthill S,Wikström AC,Poellinger L,Gustafsson JA

更新日期：1988-09-15 00:00:00