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Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts.

Abstract：

:To characterize mesenchymal stem cells (MSC), we compared gene expression profiles in human bone marrow MSC (11 lines) and human fibroblasts (4 lines) by RT-PCR and real time PCR. Messenger RNA levels of MHC-DR-alpha, MHC-DR-beta, MHC-DR-associated protein CD74, tissue factor pathway inhibitor-2, and neuroserpin were much higher in MSC than in fibroblasts, even in the presence of large interindividual variations. Those of adrenomedullin, apolipoprotein D, C-type lectin superfamily member-2, collagen type XV alpha1, CUG triplet repeat RNA-binding protein, matrix metalloproteinase-1, protein tyrosine kinase-7, and Sam68-like phosphotyrosine protein/T-STAR were lower in MSC than in fibroblasts. FACS analysis showed that cell surface expression of MHC-DR was also higher in MSC than in fibroblasts. MHC-DR expression decreased after osteogenic differentiation, whereas the expression of adrenomedullin-a potent stimulator of osteoblast activity-along with collagen XV alpha1 and apolipoprotein D increased after osteogenic differentiation. The marker genes identified in this study should be useful for characterization of MSC both in basic and clinical studies.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ishii M,Koike C,Igarashi A,Yamanaka K,Pan H,Higashi Y,Kawaguchi H,Sugiyama M,Kamata N,Iwata T,Matsubara T,Nakamura K,Kurihara H,Tsuji K,Kato Y

doi

10.1016/j.bbrc.2005.04.118

subject

Has Abstract

pub_date

2005-06-24 00:00:00

pages

297-303

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00901-0

journal_volume

332

pub_type

杂志文章

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