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Dissociation of alpha-adrenergic and cholinergic stimulated inositol trisphosphate-dependent calcium mobilization at the "post-receptor" level.

Abstract：

:Carbachol stimulated inositol trisphosphate (IP3) production and subsequent calcium mobilization in parotid cells are almost completely inhibited by neomycin. In contrast epinephrine stimulated IP3 production and calcium mobilization are much less sensitive to such inhibition. Since neomycin exerts its effects primarily at the level of inositol phosphate production and action, cholinergic and alpha adrenergic stimulation of IP3 dependent calcium mobilization may proceed through different "post-receptor" signal transduction mechanisms in parotid cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kowatch MA,Roth GS

doi

10.1016/0006-291x(89)92002-0

subject

Has Abstract

pub_date

1989-07-14 00:00:00

pages

347-51

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92002-0

journal_volume

162

pub_type

杂志文章

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