Expression of prostate specific antigen on the surface of a filamentous phage.

abstract：:gamma-glutamyltranspeptidase (GGT) is a key enzyme implicated in the homeostasis of intracellular reduced glutathione (GSH) and hence in the regulation of the cellular redox state. Besides, the extracellular cleavage of GSH by GGT leads to reactive oxygen species (ROS) production, depending on the generation and enhan...

journal_title：Biochemical and biophysical research communications

authors： Accaoui MJ,Enoiu M,Mergny M,Masson C,Dominici S,Wellman M,Visvikis A

更新日期：2000-10-05 00:00:00

abstract：:Maintaining cellular lipid composition is essential for many cell processes. Our previous study has demonstrated that Spt23 is an important transcription factor within the cell and responsible for the regulation of fatty acid desaturase genes. Disruption of SPT23 results in increased lipid saturation. In the present s...

journal_title：Biochemical and biophysical research communications

authors： Zhang M,Yu Q,Liang C,Zhang B,Li M

更新日期：2016-09-16 00:00:00

abstract：AIM:AF1q has a precise oncogenic function. The purpose of this study is to investigate whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt's lymphoma (BL), and thus has potential to enhance immunotherapy and reduce side effects. METHODS:We established BL cell lines with altered AF1q expression usin...

journal_title：Biochemical and biophysical research communications

authors： Togano T,Kim N,Kim N,Park GS,Park AK,Bennet M,Park J

更新日期：2019-11-26 00:00:00

abstract：:Skeletal muscle atrophy is an important clinical characteristic of chronic kidney disease (CKD); however, at present, the therapeutic approaches to muscle atrophy induced by CKD are still at an early stage of development. Resveratrol is used to attenuate muscle atrophy in other experimental models, but the effects on ...

journal_title：Biochemical and biophysical research communications

authors： Sun LJ,Sun YN,Chen SJ,Liu S,Jiang GR

更新日期：2017-05-20 00:00:00

abstract：:Ovarian cancer is a gynecological cancer that has the highest mortality rate and is often resistant to conventional treatments. Therefore, development of new therapies is essential. Metformin (MET), which is the priority drug for treatment of type 2 diabetes, has received increasing attention because of its anti-tumor...

journal_title：Biochemical and biophysical research communications

authors： Cui Y,Zhou J,Rong F

更新日期：2020-12-17 00:00:00

abstract：:We have isolated and purified to apparent homogeneity a serum protein which appears to be a biological marker for active rheumatoid arthritis. The protein has been found in the sera in all 44 active rheumatoid arthritis patients thus far studied and is absent from, or present in undetected amounts, in sera from normal...

journal_title：Biochemical and biophysical research communications

authors： Rosano CL,Parhami N,Hurwitz C

更新日期：1985-05-16 00:00:00

abstract：:Transfer of the gene for L-gulono-gamma-lactone oxidase, the missing enzyme in L-ascorbic acid biosynthesis in scurvy-prone animals, into medaka (Oryzias latipes) was successfully done. The expression plasmid pSVL-GLO, carrying rat liver L-gulono-gamma-lactone oxidase cDNA, was microinjected into the cytoplasm of fert...

journal_title：Biochemical and biophysical research communications

authors： Toyohara H,Nakata T,Touhata K,Hashimoto H,Kinoshita M,Sakaguchi M,Nishikimi M,Yagi K,Wakamatsu Y,Ozato K

更新日期：1996-06-25 00:00:00

abstract：:Blebbistatin is a novel 1-phenyl-2-pyrrolidinone derivative capable of inhibiting non-muscle myosin II activity with a high degree of specificity. We examined the effects of blebbistatin on pancreatic adenocarcinoma cellular migration, invasion, adhesion, and spreading. Blebbistatin dose-dependently inhibited cellular...

journal_title：Biochemical and biophysical research communications

authors： Duxbury MS,Ashley SW,Whang EE

更新日期：2004-01-23 00:00:00

abstract：:Increased protein tyrosyl phosphorylation in response to growth factors has been assumed to be solely due to activation of protein tyrosine kinases (PTKs). We report that total cellular protein tyrosine phosphatase (PTPase) activity declined in MDA-MB 468 breast carcinoma cells exposed to epidermal growth factor (EGF)...

journal_title：Biochemical and biophysical research communications

authors： Mishra S,Hamburger AW

更新日期：1993-03-31 00:00:00

abstract：:Lysophosphatidic acid (LPA), an extracellular lipid mediator, exerts various cellular effects through activation of LPA receptors, LPA1-LPA6, in many types of cells including cancer cells. We recently found several missense mutations of Lpar1 in rat cancer tissues. One of these mutations is located at the extracellula...

journal_title：Biochemical and biophysical research communications

authors： Ishii S,Tsujiuchi T,Fukushima N

更新日期：2017-05-06 00:00:00

abstract：:The binding properties of Bacillus thuringiensis toxins to brush border membrane vesicles of Dipel-resistant and -susceptible Ostrinia nubilalis larvae were compared using ligand-toxin immunoblot analysis, surface plasmon resonance (SPR), and radiolabeled toxin binding assays. In ligand-toxin immunoblot analysis, the ...

journal_title：Biochemical and biophysical research communications

authors： Li H,González-Cabrera J,Oppert B,Ferré J,Higgins RA,Buschman LL,Radke GA,Zhu KY,Huang F

更新日期：2004-10-08 00:00:00

abstract：:ARD1 protein is a mammalian gene product homologous to a yeast Ard1p (Arrest defective 1 protein) acetyltransferase. Although two alternative splicing products of ARD1, ARD1(235) and ARD1(225), were reported in mouse, only ARD1(235) orthologue was reported in humans. Here we show that ARD1(225) is not expressed in hum...

journal_title：Biochemical and biophysical research communications

authors： Chun KH,Cho SJ,Choi JS,Kim SH,Kim KW,Lee SK

更新日期：2007-02-02 00:00:00

abstract：:Halysase, a hemorrhagic metalloprotease, has an apparent molecular weight of 66kDa and belongs to the class P-III snake venom metalloprotease. Class P-III snake venom metalloproteases have multifunctional domains including a protease domain and a disintegrin-like domain. Halysase was able to preferentially hydrolyze t...

journal_title：Biochemical and biophysical research communications

authors： You WK,Jang YJ,Chung KH,Jeon OH,Kim DS

更新日期：2006-01-20 00:00:00

abstract：:To clarify the mechanism of transcriptional induction of the rat liver acyl-CoA oxidase gene by hypolipidemic agents, we searched for cis-acting regulatory sequences in the 5' upstream region of the gene by transfection studies. We found that the sequence between -639 and -472 acts as a peroxisome proliferator-respons...

journal_title：Biochemical and biophysical research communications

authors： Osumi T,Wen JK,Hashimoto T

更新日期：1991-03-29 00:00:00

abstract：:The calcium-sensing receptor (CaR) is a G protein-coupled receptor that plays key roles in extracellular calcium ion (Ca(2+)(o)) homeostasis by enabling parathyroid, kidney, and other cells to directly "sense" changes in Ca(2+)(o). In multiple myeloma-associated bone disease, myeloma cells could raise the level of Ca(...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Yamauchi M,Sugimoto T,Chauhan D,Anderson KC,Brown EM,Chihara K

更新日期：2002-12-13 00:00:00

abstract：:Hyperphosphorylation of extracellular signal-regulated protein kinases-1/2 (ERK1/2) is known to promote cancer cell proliferation. We therefore investigated the constitutive phosphorylation levels of ERK1/2 and the expression of its downstream targets c-Fos, c-Jun, and cyclooxygenase-2 (COX-2) in biopsied human gastri...

journal_title：Biochemical and biophysical research communications

authors： Wu WK,Sung JJ,Yu L,Li ZJ,Chu KM,Cho CH

更新日期：2008-08-22 00:00:00

abstract：:Cone photoreceptor subtypes having different spectral sensitivities exhibit different recovery kinetics in their photoresponses in some vertebrates. Phosphorylation by G protein-coupled receptor kinase (GRK) is essential for the rapid inactivation of light-activated visual pigment, which is the rate-limiting step of t...

journal_title：Biochemical and biophysical research communications

authors： Tsutsui K,Tachibanaki S,Shimauchi-Matsukawa Y,Shichida Y,Kawamura S

更新日期：2013-11-01 00:00:00

abstract：:ALIS are large, transient, cytosolic aggregates that serve as storage compartments for ubiquitin-tagged defective ribosomal products. We determined the importance of the protein p62 in the formation of ALIS and demonstrated that two domains of p62-PB1 and UBA-are essential for ALIS assembly. Those two major binding do...

journal_title：Biochemical and biophysical research communications

authors： Cabe M,Rademacher DJ,Karlsson AB,Cherukuri S,Bakowska JC

更新日期：2018-09-18 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a vital role in vasculature response to hemodynamic stimuli via the degradation of extracellular matrix substrates. In this study, we investigated the putative role of cyclic strain-induced endothelial MMP-2 (and MMP-9) expression and release in modulating bovine aortic smooth mus...

journal_title：Biochemical and biophysical research communications

authors： von Offenberg Sweeney N,Cummins PM,Birney YA,Redmond EM,Cahill PA

更新日期：2004-07-23 00:00:00

abstract：:The human 5-HT1A receptor was screened for naturally occurring mutations. The PCR product of the 5-HT1A receptor gene was digested with several restriction enzymes and evaluated by single-strand conformational polymorphism (SSCP) analysis. Comparison of the SSCP electrophoretic pattern with a restriction map of the 5-...

journal_title：Biochemical and biophysical research communications

authors： Nakhai B,Nielsen DA,Linnoila M,Goldman D

更新日期：1995-05-16 00:00:00

abstract：:Crystallographic studies have shown independent binding sites for sugar and peptide ligands of concanavalin A, although they were considered functional mimics based on biochemical experiments. The topological correlation of 12-residue peptide with different carbohydrate ligands of concanavalin A showed similarity betw...

journal_title：Biochemical and biophysical research communications

authors： Jain D,Kaur KJ,Goel M,Salunke DM

更新日期：2000-06-16 00:00:00

abstract：:We have found that the alkyl-lysophospholipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) was able to induce apoptosis in human promyelocytic HL-60 leukemic cells, as evidenced by the internucleosomal degradation of the cellular DNA into the characteristic 180-200 bp DNA fragments. This effect was o...

journal_title：Biochemical and biophysical research communications

authors： Mollinedo F,Martínez-Dalmau R,Modolell M

更新日期：1993-04-30 00:00:00

abstract：:We have constructed an expression plasmid for regulated expression of the hepatitis B surface antigen gene in yeast using promoter of the yeast Pho5 gene. In the yeast transformants, the monomeric HBsAg (22K dalton) was estimated to constitute approximately 3% of the total proteins. On extraction, the HBsAg was found ...

journal_title：Biochemical and biophysical research communications

authors： Choo KB,Wu SM,Lee HH,Lo SC

更新日期：1985-08-30 00:00:00

abstract：:In the present study, we characterized two new SF-1 binding sites, SF-209 and SF-98, in the promoter of the human ACTH receptor (hACTH-R) gene. Both sites, together with the previously described SF-35 site, are required for full constitutive activity of this gene. This was demonstrated by the use of constructs contain...

journal_title：Biochemical and biophysical research communications

authors： Naville D,Penhoat A,Durand P,Begeot M

更新日期：1999-02-05 00:00:00

abstract：:A calcium-calmodulin (Ca2(+)-CaM) stimulated histone H3 phosphorylating activity was identified as a component of a nuclear protein complex purified from a 150 mM NaCl extract of calf thymus chromatin. This activity bound to a CaM-Sepharose affinity column in a Ca2+ dependent manner and was eluted off the column in th...

journal_title：Biochemical and biophysical research communications

authors： Wakim BT,Picken MM,DeLange RJ

更新日期：1990-08-31 00:00:00

abstract：:The present study investigates the immunomodulatory activities of buckwheat polysaccharide fraction (BPF) from the seed of Fagopyrum esculentum on RAW 264.7 macrophage cell line and Cyclophosphamide-induced immunosuppressed conditions in mice models. The results of in vitro showed that treatment with 0.5-10 μg/mL of B...

journal_title：Biochemical and biophysical research communications

authors： Oh MJ,Choi HD,Ha SK,Choi I,Park HY

更新日期：2018-02-19 00:00:00

abstract：:Mutations in collagen II are associated with spondyloepiphyseal dysplasia, a group of heritable diseases whose common features include aberrations of skeletal growth. The mechanisms through which mutations in collagen II affect the cartilaginous tissues are complex and include both intracellular and extracellular proc...

journal_title：Biochemical and biophysical research communications

authors： Gawron K,Jensen DA,Steplewski A,Fertala A

更新日期：2010-05-28 00:00:00

abstract：:Familial exudative vitreoretinopathy (FEVR) is a congenital hereditary, bilateral eye disorder which affects both retina and the vitreous body. As a first step toward the identification of the gene responsible for the X-linked disorder, we report here the results of DNA analyses from the patients and their parents of ...

journal_title：Biochemical and biophysical research communications

authors： Shastry BS,Trese MT

更新日期：1993-06-15 00:00:00

abstract：:The cAMP response element binding protein (CREB) is expressed at constitutively low levels in most cell types, and the CREB promoter possesses features that are typical of house-keeping genes. Since the CREB promoter also contains sequences which can mediate cAMP responsiveness in transfection experiments, it has been...

journal_title：Biochemical and biophysical research communications

authors： Crosson SM,Davies GF,Roesler WJ

更新日期：1996-10-23 00:00:00

abstract：:The effect of blue background light on behavioral response of Halobacterium halobium to step-like stimulation with green-orange attractant light was examined. The results strongly support the previously proposed hypothesis that a long-lifetime photointermediate of s-rhodopsin is the photoreceptor for repellent light: ...

journal_title：Biochemical and biophysical research communications

authors： Takahashi T,Mochizuki Y,Kamo N,Kobatake Y

更新日期：1985-02-28 00:00:00