Abstract：
:Maintaining cellular lipid composition is essential for many cell processes. Our previous study has demonstrated that Spt23 is an important transcription factor within the cell and responsible for the regulation of fatty acid desaturase genes. Disruption of SPT23 results in increased lipid saturation. In the present study, we found that lipid saturation caused by SPT23 deletion exhibited a growth defect under ethanol stress and increased chitin contents. Ergosterol synthesis-related genes were up-regulated to protect cells from plasma membrane damage in the presence of ethanol. The cell wall stress caused by increased chitin contents could not be attenuated by up-regulation of phospholipids synthesis-related genes in spt23Δ. Besides, lipid saturation induced expression of unfolded protein response (UPR) genes and reactive oxygen species (ROS) accumulation followed by activation of the cellular antioxidant system, which is associated with endoplasmic reticulum functions. Taken together, our data suggested that lipid homeostasis has a close connection with cell responses to both plasma membrane stress and endoplasmic reticulum stress.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Zhang M,Yu Q,Liang C,Zhang B,Li Mdoi
10.1016/j.bbrc.2016.08.024subject
Has Abstractpub_date
2016-09-16 00:00:00pages
777-83issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(16)31279-7journal_volume
478pub_type
杂志文章abstract：:A single intraperitoneal injection of 275 mg of dimethyl sulphoxide (DMSO) to rats (100-125 g body weight) effectively uncouples oxidative phosphorylation in liver mitochondria during the period from 2 hr to 5 day post-injection. Higher doses of DMSO are inhibitory to mitochondrial respiration. DMSO has however no unc...
journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/0006-291x(83)91299-8
更新日期：1983-01-14 00:00:00
abstract：:We have studied the effects of epidermal growth factor (EGF) on both cholecystokinin octapeptide (CCK-OP)-induced inositol-1,4,5 trisphosphate (IP3) production and on cytosolic free calcium concentrations [Ca2+]i by fluorescence measurements in fura-2-loaded pancreatic acini. Our data show that EGF inhibits CCK-OP ind...
journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(05)81150-7
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.2001.5210
更新日期：2001-07-20 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2007.12.138
更新日期：2008-03-07 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2005.08.271
更新日期：2005-11-11 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(05)81282-3
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(86)80276-5
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(88)80677-6
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2012.09.006
更新日期：2012-10-12 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章,评审
doi：10.1016/j.bbrc.2011.08.062
更新日期：2011-09-16 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1995.1968
更新日期：1995-07-17 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/0006-291x(89)92336-x
更新日期：1989-09-15 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2005.01.133
更新日期：2005-04-01 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2005.11.149
更新日期：2006-02-03 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1997.6607
更新日期：1997-05-08 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(03)01364-0
更新日期：2003-08-22 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(88)80493-5
更新日期：1988-03-30 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2009.01.039
更新日期：2009-02-27 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1994.2792
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(05)81296-3
更新日期：1991-10-15 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1995.2232
更新日期：1995-08-24 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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更新日期：2007-08-24 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/0006-291x(90)90637-3
更新日期：1990-03-30 00:00:00
abstract：:The mechanisms of liver injury in hepatitis B virus (HBV) infection are defined to be due not to the direct cytopathic effects of viruses, but to the host immune response to viral proteins expressed by infected hepatocytes. We showed here that transfection of mammalian cells with a replicative HBV genome causes extens...
journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/j.bbrc.2006.10.002
更新日期：2006-12-08 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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更新日期：2003-07-11 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1006/bbrc.1997.6651
更新日期：1997-05-19 00:00:00
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journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
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更新日期：2004-11-26 00:00:00
abstract：:Secretory granules obtained from bovine pituitary, atrium and adrenal medulla contain an extremely acidic copper protein resembling by its main physico-chemical and antigenic properties as well as by the ability of its apoform to inhibit dopamine beta-monooxygenase the protein from brain, neurocuprein. ...
journal_title：Biochemical and biophysical research communications
pub_type： 杂志文章
doi：10.1016/s0006-291x(88)81301-9
更新日期：1988-09-30 00:00:00
