当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Cyclic AMP-stimulated accumulation of the cAMP response element binding protein can occur without changes in gene expression.

Cyclic AMP-stimulated accumulation of the cAMP response element binding protein can occur without changes in gene expression.

Abstract：

:The cAMP response element binding protein (CREB) is expressed at constitutively low levels in most cell types, and the CREB promoter possesses features that are typical of house-keeping genes. Since the CREB promoter also contains sequences which can mediate cAMP responsiveness in transfection experiments, it has been proposed that transcription of the CREB gene is controlled by positive autoregulation. In the present study, we show that cAMP does not regulate the level of CREB mRNA in any of the tissue-or cell-types that we examined, nor is expression regulated by other hormones which commonly affect gene expression. However, treatment of rat hepatoma cells with cAMP did result in accumulation of CREB protein. We conclude that the positive autoregulation of CREB expression which has been proposed is not ubiquitously operational, although CREB protein levels can be regulated in a cell-specific manner which does not involve transcriptional activation of the CREB gene.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Crosson SM,Davies GF,Roesler WJ

doi

10.1006/bbrc.1996.1605

subject

Has Abstract

pub_date

1996-10-23 00:00:00

pages

915-20

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91605-8

journal_volume

227

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe.

    abstract：:The addition of the chemotactic factor fMet-Leu-Phe to cell homogenates causes a decrease in the pertussis toxin catalyzed ADP-ribosylation of a 41 kDa protein. The fMet-Leu-Phe induced decrease is not abolished in homogenates prepared from phorbol 12-myristate 13-acetate treated neutrophils. This decreased ribosylati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91380-5

    authors： Matsumoto T,Molski TF,Kanaho Y,Becker EL,Sha'afi RI

    更新日期：1987-03-13 00:00:00

  • Unique hexameric structure of copper-containing nitrite reductase of an anammox bacterium KSU-1.

    abstract：:Anaerobic ammonium oxidation (anammox) and denitrification are two different microbial reactions that form nitrogen gas. The initial step in the anammox reaction-reduction of nitrite to nitric oxide-is thought to be catalyzed by homologs of dissimilatory nitrite reductase, which is known to be involved in denitrificat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.03.144

    authors： Hira D,Matsumura M,Kitamura R,Furukawa K,Fujii T

    更新日期：2020-06-04 00:00:00

  • Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.

    abstract：:5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO product...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2010.02.173

    authors： Rådmark O,Samuelsson B

    更新日期：2010-05-21 00:00:00

  • Small heat-shock proteins function in the insoluble protein complex.

    abstract：:Small heat-shock proteins (sHSPs) represent an abundant and ubiquitous family of molecular chaperones. The current model proposes that sHSPs function to prevent irreversible aggregation of non-native proteins by forming soluble complex. The chaperone activity of sHSPs is usually determined by the capacity to suppress ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.07.065

    authors： Jiao W,Li P,Zhang J,Zhang H,Chang Z

    更新日期：2005-09-16 00:00:00

  • Calmodulin regulation of cholinergic muscarinic receptor: effects of calcium and phosphorylating states.

    abstract：:Calmodulin (CaM) regulation of cholinergic muscarinic receptor was investigated using synaptic membrane isolated from rat brains and [3H]-QNB as a binding ligand. CaM exerts a biphasic effect on receptor binding showing both a Ca2+-dependent receptor loss and an increase depending on the state of membrane phosphorylat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91263-x

    authors： Ho AK,Wang JH

    更新日期：1985-12-31 00:00:00

  • Role of chemokine and cytokine polymorphisms in the progression of HIV-1 disease.

    abstract：:Allelic variants of the genes for chemokine receptors and their natural ligands, the chemokines, and cytokines can affect HIV-1 disease progression. This study investigates the level of expression of the CCR5-Delta32, CCR2b-641, RANTES In1.1C, SDF-1 3'A, IL-10-5'-592A and IL-4-589T alleles in two unique HIV-1 infected...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.04.095

    authors： Mahajan SD,Agosto-Mojica A,Aalinkeel R,Reynolds JL,Nair BB,Sykes DE,Martinez J,Adams J,Singh N,Bernstein Z,Hsiao CB,Schwartz SA

    更新日期：2010-05-28 00:00:00

  • Purification of recombinant human tumor necrosis factor precursor from Escherichia coli.

    abstract：:To study its biological functions, tumor necrosis factor precursor (proTNF) with a molecular size of 26-KDa was obtained as a recombinant protein from Escherichia coli. The recombinant proTNF was successfully accumulated in the insoluble form, corresponding to about 10-15% of total E. coli proteins. Solubilization, ge...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91426-d

    authors： Tanabe Y,Noguchi K,Morikawa A,Mizuno D,Soma G

    更新日期：1991-08-30 00:00:00

  • Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor.

    abstract：:The human amyloid beta protein (BP) is a major constituent of the amyloid deposited in the brain of patients with Alzheimer's disease and is derived from a larger precursor protein (BPP). In human three alternatively-spliced forms of BPP mRNA were found and two of them were shown to encode a protease inhibitory activi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92808-8

    authors： Yamada T,Sasaki H,Dohura K,Goto I,Sakaki Y

    更新日期：1989-02-15 00:00:00

  • Adenovirus-mediated murine interferon-gamma receptor transfer enhances the efficacy of IFN-gamma in vivo.

    abstract：:Interferon gamma (IFN-gamma) plays an important role in immune response, apoptosis, and anti-tumor activity. Its biological activity depends on expression of IFN-gamma receptor (IFN-gammaR). To address whether increased expression of IFN-gammaR is associated in vivo with a higher biological response by IFN-gamma, we c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6298

    authors： Nishida Y,Maeda Y,Hara A,Arima T,Kimura E,Yamashita S,Uyama E,Mita S,Uchino M

    更新日期：2002-01-25 00:00:00

  • Enhanced detection and characterization of protocatechuate 3,4-dioxygenase in Acinetobacter lwoffii K24 by proteomics using a column separation.

    abstract：:Acinetobacter lwoffii K24 known as an aniline degrading bacterium has also been found to utilize p-hydroxybenzoate as a sole carbon source. In this study, 2-DE using Q-Sepharose column separation was attempted for fast screening of protocatechuate 3,4-dioxygenase for catabolism of p-hydroxybenzoate in A. lwoffii K24. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)00778-7

    authors： Kahng HY,Cho K,Song SY,Kim SJ,Leem SH,Kim SI

    更新日期：2002-07-26 00:00:00

  • SNHG11 promotes cell proliferation in colorectal cancer by forming a positive regulatory loop with c-Myc.

    abstract：:Dysregulation of long non-coding RNAs (lncRNA) have long been linked to the onset and development of colorectal cancer (CRC), yet the underlying mechanisms remain elusive. Small nucleolar RNA host gene 11 (SNHG11) is a novel lncRNA with few information about its role in development and progression of CRC. Here, we fou...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.05.002

    authors： Huang W,Dong S,Cha Y,Yuan X

    更新日期：2020-07-05 00:00:00

  • Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells.

    abstract：:Therapeutic efficacy of a synthetic somatostatin analogue for the treatment of carcinoid tumors is still controversial. In vivo studies performed in our laboratory showed that a somatostatin analogue, SMS 201-995, significantly inhibited growth of human pancreatic carcinoid (BON) tumors xenotransplanted into athymic n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91663-b

    authors： Ishizuka J,Beauchamp RD,Evers BM,Townsend CM Jr,Thompson JC

    更新日期：1992-06-15 00:00:00

  • Differences in the betaC-S lyase activities of viridans group streptococci.

    abstract：:betaC-S Lyase catalyzes the alpha,beta-elimination of L-cysteine to hydrogen sulfide, which is one of the main causes of oral malodor and is highly toxic to mammalian cells. We evaluated the capacity of six species of oral streptococci to produce hydrogen sulfide. The crude enzyme extract from Streptococcus anginosus ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02803-6

    authors： Yoshida Y,Negishi M,Amano A,Oho T,Nakano Y

    更新日期：2003-01-03 00:00:00

  • Modulation of insulin secretion and glycemia by selective inhibition of cyclic AMP phosphodiesterase III.

    abstract：:The effects of selective inhibition of cyclic AMP phosphodiesterase type III on insulin and glucose levels during an oral glucose challenge were evaluated in obese, diabetic ob/ob mice and in lean, non-diabetic littermates using the selective inhibitor, milrinone. Oral administration of milrinone increased plasma insu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7034

    authors： Parker JC,VanVolkenburg MA,Nardone NA,Hargrove DM,Andrews KM

    更新日期：1997-07-30 00:00:00

  • Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species.

    abstract：:Our previous studies have shown that the liver from Naked Mole Rats (NMRs), a long-lived rodent, has increased proteasome activity and lower levels of protein ubiquitination compared to mice. This suggests that protein quality control might play a role in assuring species longevity. To determine whether enhanced prote...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.01.046

    authors： Pride H,Yu Z,Sunchu B,Mochnick J,Coles A,Zhang Y,Buffenstein R,Hornsby PJ,Austad SN,Pérez VI

    更新日期：2015-02-20 00:00:00

  • Epidermal growth factor counteracts insulin-induced expression of glucokinase in hepatocytes.

    abstract：:Hepatic glucokinase is induced by insulin and repressed by glucagon. The effects of epidermal growth factor (EGF) on glucokinase expression were investigated in rat hepatocytes. EGF does not affect the decline in glucokinase activity in hepatocytes cultured for 48h in the absence of insulin, but it counteracts the inc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1787

    authors： Beresford GW,Agius L

    更新日期：1994-06-15 00:00:00

  • Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation.

    abstract：:Alpha-synuclein (alpha-syn) amyloid filaments are the major ultrastructural component of pathological inclusions that define several neurodegenerative disorders, including Parkinson disease and other disorders that are collectively termed synucleinopathies. Since the aggregation of alpha-syn is associated with the eti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.12.079

    authors： Waxman EA,Emmer KL,Giasson BI

    更新日期：2010-01-15 00:00:00

  • Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation.

    abstract：:Protein, mRNA and activity levels of the calcium-independent protein kinase C (nPKC) isoenzymes were examined in NG108-15 cells. Western blot analyses reveal that proliferating NG 108-15 cells express the delta, epsilon, and eta, but not the theta species. The atypical species PKC zeta was also detected. Differentiati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2344

    authors： Battaini F,Pascale A,Lucchi L,Racchi M,Bergamaschi S,Parenti M,Wetsel WC,Govoni S,Trabucchi M

    更新日期：1994-09-30 00:00:00

  • Possible participation of calmodulin in stimulation of leucine transport by concanavalin A in human lymphocytes.

    abstract：:Stimulation of leucine uptake by addition of concanavalin A, mediated by increase of intracellular free Ca2+ concentration [( Ca2+]), in lymphocytes (Mitsumoto, Y., Sato, K. and Mohri, T. (1988) Biochim. Biophys. Acta 968, 353-358) was abolished by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and chlorprom...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81133-1

    authors： Sato K,Mitsumoto Y,Mohri T

    更新日期：1988-06-16 00:00:00

  • Structural differences in the ability of lysophospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric arteries.

    abstract：:The effects of different lysophospholipids on endothelium-dependent hyperpolarization by acetylcholine were examined in rat mesenteric arteries. Lysophosphatidylcholine with 14 or longer carbon acyl chain significantly inhibited the hyperpolarization, while that with 12 or lesser carbon acyl chain was without effect. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1532

    authors： Fukao M,Hattori Y,Kanno M,Sakuma I,Kitabatake A

    更新日期：1996-10-14 00:00:00

  • PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) participates in the process of insulin resistance (IR), a crucial pathophysiology in non-alcoholic fatty liver disease (NAFLD). Meanwhile, suppressor of cytokine signaling3 (SOCS3) also regulates IR in NAFLD. Both PPARγ and SOCS3 play a role in NAFLD through reg...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.03.110

    authors： Bi J,Sun K,Wu H,Chen X,Tang H,Mao J

    更新日期：2018-04-15 00:00:00

  • Developmental expression of maf-1 messenger ribonucleic acids in rat kidney by in situ hybridization histochemistry.

    abstract：:maf is a family of oncogenes, originally identified from the avian oncogenic retrovirus AS42, which encodes a nuclear bZip transcription factor protein. It has been reported that maf family genes have critical roles in embryological development and cellular differentiation. In this study, the distribution of maf-1 gen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2865

    authors： Imaki J,Onodera H,Tsuchiya K,Imaki T,Mochizuki T,Mishima T,Yamashita K,Yoshida K,Sakai M

    更新日期：2000-06-16 00:00:00

  • Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes.

    abstract：:Chondrocyte mechanotransduction in response to mechanical loading is essential for the health and homeostasis of articular cartilage. The actin cytoskeleton has been implicated in cell mechanics and mechanotransduction. This study tests the hypothesis that loading modulates actin dynamics and organisation with subsequ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.06.185

    authors： Campbell JJ,Blain EJ,Chowdhury TT,Knight MM

    更新日期：2007-09-21 00:00:00

  • Two lutein molecules in LHCII have different conformations and functions: Insights into the molecular mechanism of thermal dissipation in plants.

    abstract：:When LHCII forms aggregates, the internal conformational changes will result in chlorophyll fluorescence quenching. Uncovering the molecular mechanism of this phenomenon will help us to understand how plants dissipate the excess excitation energy through non-photochemical quenching (NPQ) process. The crystal structure...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.172

    authors： Yan H,Zhang P,Wang C,Liu Z,Chang W

    更新日期：2007-04-06 00:00:00

  • Upregulation of LINC00963 facilitates melanoma progression through miR-608/NACC1 pathway and predicts poor prognosis.

    abstract：:Long noncoding RNAs (lncRNAs) are acknowledged as crucial regulators involved in multiple pathological processes, including cancer. Although some lncRNAs are studied in melanoma, the association between lncRNA and melanoma progression still remains vague. And the function of LINC00963 in melanoma is waiting for invest...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.08.115

    authors： Jiao H,Jiang S,Wang H,Li Y,Zhang W

    更新日期：2018-09-26 00:00:00

  • Alpha-shaped DNA loops induced by MutS.

    abstract：:DNA mismatch repair (MMR) is critical for the maintenance of genomic stability. MMR is initiated by recognition of DNA mismatches by the protein, MutS, which subsequently recruits downstream repair factors. To better understand the mechanism by which MutS identifies and specifically binds mismatched basepairs embedded...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.093

    authors： Jia Y,Bi L,Li F,Chen Y,Zhang C,Zhang X

    更新日期：2008-08-08 00:00:00

  • Acetaldehyde-dependent oxidation of glutathione catalyzed by rat liver cytosol.

    abstract：:We have identified a novel reaction in which acetaldehyde promotes rat hepatic cytosolic catalysis of O2 consumption coupled with glutathione oxidation without apparent release of activated forms of O2. Acetaldehyde is not consumed in the reaction. The reaction (O2 consumption or oxidized glutathione production) is sa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91983-7

    authors： Lyon I,Kaplowitz N

    更新日期：1985-06-28 00:00:00

  • Expression of c-myc oncogene during differentiation of human burst-forming unit, erythroid (BFU-E).

    abstract：:We investigated the serial expression of c-myc oncogene during differentiation of normal human burst-forming unit, erythroid (BFU-E), in vitro, together with the replating efficiency and the expression of transferrin receptors. We found that the c-myc oncogene was expressed in the early progeny of BFU-E and that this ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90025-2

    authors： Umemura T,Umene K,Nishimura J,Fukumaki Y,Sakaki Y,Ibayashi H

    更新日期：1986-03-13 00:00:00

  • Upstream stimulatory factors regulate the C/EBP alpha gene during differentiation of 3T3-L1 preadipocytes.

    abstract：:During adipocyte differentiation, CCAAT/enhancer-binding protein alpha (C/EBPalpha) functions as a pleiotropic transcriptional activator of numerous adipocyte genes. The promoter of the C/EBPalpha gene has an E-box upstream of C/EBP binding site. Deletion or mutation of the E-box decreases promoter activity, suggestin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.008

    authors： Kim JW,Monila H,Pandey A,Lane MD

    更新日期：2007-03-09 00:00:00

  • Implication of novel biochemical property of beta-amyloid.

    abstract：:Alzheimer disease (AD) is a heterogeneous disorder with a variety of molecular pathologies converging predominantly on abnormal amyloid deposition particularly in the brain. beta-Amyloid aggregation into senile plaques is one of the pathological hallmarks of AD. beta-Amyloid is generated by a proteolytic cleavage of a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.2024

    authors： Elbaum D,Brzyska M,Bacia A,Alkon DL

    更新日期：2000-01-27 00:00:00