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Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.

Abstract：

:5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO products in relation to tumorigenesis have been described. Thus, insight regarding the biochemistry of 5LO is relevant for better understanding of normal physiology, and for development of therapy.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rådmark O,Samuelsson B

doi

10.1016/j.bbrc.2010.02.173

subject

Has Abstract

pub_date

2010-05-21 00:00:00

pages

105-10

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00417-1

journal_volume

396

pub_type

杂志文章,评审

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