Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site.

abstract：:Vaspin, an adipocytokine recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. However, the exact mechanism underlying this action has not been fully elucidated. Furthermore, the specific function of vaspin is largely unknown, especially in vascular cells. We ...

journal_title：Biochemical and biophysical research communications

authors： Jung CH,Lee WJ,Hwang JY,Seol SM,Kim YM,Lee YL,Park JY

更新日期：2011-09-23 00:00:00

abstract：:Phosgene is a toxic gas that is widely used in modern industry, and its inhalation can cause severe pulmonary edema. There is no effective clinical treatment because the mechanism of phosgene-induced pulmonary edema still remains unclear. Many studies have demonstrated that the Na(+)/K(+)-ATPase plays a critical role ...

journal_title：Biochemical and biophysical research communications

authors： Qin XJ,Li YN,Liang X,Wang P,Hai CX

更新日期：2008-02-29 00:00:00

abstract：:The molecular steps of the electron transfer in the endoplasmic reticulum from the secreted proteins during their oxidation are relatively unknown. We present here that flavine adenine dinucleotide (FAD) is a powerful oxidizer of the oxidoreductase system, Ero1 and PDI, besides the proteins of rat liver microsomes and...

journal_title：Biochemical and biophysical research communications

authors： Papp E,Nardai G,Mandl J,Bánhegyi G,Csermely P

更新日期：2005-12-16 00:00:00

abstract：:Osteoclasts are hematopoietic cells essential for bone resorption. To understand the process of osteoclastogenesis, we have developed a culture system that employs a stromal cell line, in which differentiation of osteoclasts from single embryonic stem (ES) cells occurs. This culture, which did not require any cell pas...

journal_title：Biochemical and biophysical research communications

authors： Hemmi H,Okuyama H,Yamane T,Nishikawa S,Nakano T,Yamazaki H,Kunisada T,Hayashi S

更新日期：2001-01-19 00:00:00

abstract：:The glycoprotein processing inhibitors bromoconduritol and N-methyl-1-deoxynojirimycin inhibit myoblast fusion and differentiation, suggesting the critical involvement of one or more glycoproteins in the control of skeletal myogenesis. In the present study we have examined the effect of inhibitors of glycoprotein proc...

journal_title：Biochemical and biophysical research communications

authors： Trudel GC,Holland PC

更新日期：1992-04-15 00:00:00

abstract：:Approximately 80% of ovarian cancer (OC) is diagnosed at late stages, and most patients die within 5 years of diagnosis due to recurrence or drug resistance. Novel treatments are required to improve patient survival. Immune therapy against cancer is promising; however, therapeutic vaccination has been limited by the i...

journal_title：Biochemical and biophysical research communications

authors： Yu W,Qu H,Cao G,Liu C,Deng H,Zhang Z

更新日期：2017-12-09 00:00:00

abstract：:Adiponectin, an adipose-derived hormone, exhibits various biological functions, such as increasing insulin sensitivity, protecting hypertension, and suppression of atherosclerosis, liver fibrosis, and tumor growth. Here, we report the role of adiponectin on bone metabolism. C57BL/6J mice were treated with adenovirus e...

journal_title：Biochemical and biophysical research communications

authors： Oshima K,Nampei A,Matsuda M,Iwaki M,Fukuhara A,Hashimoto J,Yoshikawa H,Shimomura I

更新日期：2005-06-03 00:00:00

abstract：:Expression of foreign genes in vivo is a standard method to disclose functions of specific genes and to alter physiological conditions in distinct cell types and tissues. Virus-mediated gene transfer has proved to be a valuable tool for directed gene expression in vivo complementary to transgenic approaches. However, ...

journal_title：Biochemical and biophysical research communications

authors： Ebelt H,Braun T

更新日期：2003-10-31 00:00:00

abstract：:We propose a multiple alignment of the sequence of formate dehydrogenase with the D-specific 2-hydroxy acid dehydrogenases family. Structurally conserved regions are predicted for those sequences corresponding to important regions of the catalytic and the coenzyme binding domains defined from the known three-dimension...

journal_title：Biochemical and biophysical research communications

authors： Vinals C,Depiereux E,Feytmans E

更新日期：1993-04-15 00:00:00

abstract：:Angiotensin II (Ang-II) has been shown to possess several atherogenic properties including its ability to induce macrophage-mediated oxidation of LDL and to form Ang-II-modified LDL which is taken up by macrophages at enhanced rate. Oxidized-LDL (Ox-LDL) is also taken up by macrophages at enhanced rate via several sca...

journal_title：Biochemical and biophysical research communications

authors： Keidar S,Attias J

更新日期：1997-10-09 00:00:00

abstract：:Osterix (Osx) is an essential transcription factor required for osteoblast differentiation during both intramembranous and endochondral ossification. Endochondral ossification, a process in which bone formation initiates from a cartilage intermediate, is crucial for skeletal development and growth. Osx is expressed in...

journal_title：Biochemical and biophysical research communications

authors： Oh JH,Park SY,de Crombrugghe B,Kim JE

更新日期：2012-02-24 00:00:00

abstract：:Histone deacetylases (HDAC) form a conserved enzyme family that control gene expression via the removal of acetyl residues from histones and other proteins and are under increasing investigation as therapeutic targets, notably in cancer and parasitic diseases. To investigate the conservation of these enzymes in the pl...

journal_title：Biochemical and biophysical research communications

authors： Oger F,Dubois F,Caby S,Noël C,Cornette J,Bertin B,Capron M,Pierce RJ

更新日期：2008-12-26 00:00:00

abstract：:Tetrodotoxin-binding sites were covalently labelled with a highly tritiated derivative of tetrodotoxin. Cross-linking experiments, using dissucinimidyl suberate, on partially purified tetrodotoxin-binding component from electroplax of Electrophorus electricus, revealed covalent labelling of a single polypeptide chain ...

journal_title：Biochemical and biophysical research communications

authors： Lombet A,Norman RI,Lazdunski M

更新日期：1983-07-18 00:00:00

abstract：:Stefin B is the major general cytosolic protein inhibitor of cysteine cathepsins. Its main function is to protect the organism against the activity of endogenous potentially hazardous proteases accidentally released from lysosomes. In this study, we investigated the possible effect of endosomal/lysosomal aspartic cath...

journal_title：Biochemical and biophysical research communications

authors： Železnik TZ,Kadin A,Turk V,Dolenc I

更新日期：2015-09-18 00:00:00

abstract：:Diphtheria toxin is translocated across cellular membranes when receptor-bound toxin is exposed to low pH. To study the role of sphingolipids for toxin translocation, both a mutant cell line lacking the first enzyme in de novo sphingolipid synthesis, serine palmitoyltransferase, and a specific inhibitor of the same en...

journal_title：Biochemical and biophysical research communications

authors： Spilsberg B,Hanada K,Sandvig K

更新日期：2005-04-08 00:00:00

abstract：:The IGF-I receptor binds IGF-I with complex kinetics characterized by a curvilinear Scatchard plot, suggesting receptor heterogeneity and apparent negative cooperativity. To explore the molecular mechanisms underlying these properties, we have characterized the binding of a hybrid receptor formed from a wild-type rece...

journal_title：Biochemical and biophysical research communications

authors： Chakravarty A,Hinrichsen J,Whittaker L,Whittaker J

更新日期：2005-05-27 00:00:00

abstract：:HCV and HBV are the major causes of chronic liver diseases worldwide. Patients with both viruse's co-infection tend to develop severer liver diseases and are at high risk of liver-related death. NS5A protein of HCV plays key roles in HCV replication and inhibition of host immune responses. In this study, we described ...

journal_title：Biochemical and biophysical research communications

authors： Pan Y,Wei W,Kang L,Wang Z,Fang J,Zhu Y,Wu J

更新日期：2007-07-20 00:00:00

abstract：:Manganese-dependent superoxide dismutase (MnSOD) is localized in the mitochondria and is important for oxidative stress resistance. Although transcriptional regulation of MnSOD has been relatively well studied, much less is known about the protein's posttranslational regulation. In budding yeast, MnSOD is activated af...

journal_title：Biochemical and biophysical research communications

authors： Takahashi H,Suzuki T,Shirai A,Matsuyama A,Dohmae N,Yoshida M

更新日期：2011-03-04 00:00:00

abstract：:The bacterioferritin-associated ferredoxin (Bfd) of Escherichia coli is a 64-residue polypeptide encoded by the bfd gene located upstream of the gene (bfr) encoding the iron-storage haemoprotein, bacterioferritin. The Bfd sequence resembles those of the approximately 60-residue domains found in NifU proteins (required...

journal_title：Biochemical and biophysical research communications

authors： Quail MA,Jordan P,Grogan JM,Butt JN,Lutz M,Thomson AJ,Andrews SC,Guest JR

更新日期：1996-12-13 00:00:00

abstract：:A folded synthetic peptide analog of NDF (NDF5), which has the 52 amino acid EGF-like domain of NDF alpha 2, has been characterized. The folded peptide stimulates tyrosine phosphorylation of Her2, Her3 and Her4 in breast cancer cells and competes with low affinity with full-length NDF alpha 2 for binding to the cells,...

journal_title：Biochemical and biophysical research communications

authors： Kita Y,Mayer J,Zamborelli T,Hara S,Rohde M,Watson E,Koski R,Ratzkin B,Nicolson M

更新日期：1995-05-16 00:00:00

abstract：:Thick filaments from some striated muscles are regulated by phosphorylation of myosin regulatory light chains (RLCs). A tarantula thick filament quasi-atomic model achieved by cryo-electron microscopy has advanced our understanding on how this regulation occurs. In native thick filaments, an asymmetric intramolecular ...

journal_title：Biochemical and biophysical research communications

authors： Sulbarán G,Biasutto A,Méndez F,Pinto A,Alamo L,Padrón R

更新日期：2020-03-26 00:00:00

abstract：:The insulin receptor gene is induced 8 to 10-fold during adipocyte differentiation. Plasmids containing the promoter, exon 1 and a portion of the first intron from either the mouse or human gene are able to modulate the expression of an insulin receptor/CAT gene 3 to 7-fold during differentiation. We have shown that s...

journal_title：Biochemical and biophysical research communications

authors： McKeon C,Accili D,Chen H,Pham T,Walker GE

更新日期：1997-11-26 00:00:00

abstract：:Recent studies have highlighted that cancer cells with a loss of the SWI/SNF complex catalytic subunit BRG1 are dependent on the remaining ATPase, BRM, making it an attractive target for cancer therapy. However, an understanding of the extent of target inhibition required to arrest cell growth, necessary to develop an...

journal_title：Biochemical and biophysical research communications

authors： Rago F,DiMare MT,Elliott G,Ruddy DA,Sovath S,Kerr G,Bhang HC,Jagani Z

更新日期：2019-01-01 00:00:00

abstract：:With the emergence of electrospray ionization mass spectrometry (ESI-MS), mass spectrometry is no longer restricted to the study of small, stable molecules, but has become a viable technique to study large biomolecules as well as noncovalent biomolecular complexes. ESI-MS has been used to study noncovalent interaction...

journal_title：Biochemical and biophysical research communications

authors： Veenstra TD

更新日期：1999-04-02 00:00:00

abstract：:AK2 is an adenylate phosphotransferase that localizes at the intermembrane spaces of the mitochondria, and its mutations cause a severe combined immunodeficiency with neutrophil maturation arrest named reticular dysgenesis (RD). Although the dysfunction of hematopoietic stem cells (HSCs) has been implicated, earlier d...

journal_title：Biochemical and biophysical research communications

authors： Oshima K,Saiki N,Tanaka M,Imamura H,Niwa A,Tanimura A,Nagahashi A,Hirayama A,Okita K,Hotta A,Kitayama S,Osawa M,Kaneko S,Watanabe A,Asaka I,Fujibuchi W,Imai K,Yabe H,Kamachi Y,Hara J,Kojima S,Tomita M,Soga T,

更新日期：2018-03-04 00:00:00

abstract：:Since otoacoustic emissions were discovered, the old idea of a second (active) filter in the cochlea has been pursued with considerable dedication. In this contribution a concept explaining the action of the second filter is presented, which is derived from high-frequency resonance: The outer hair cells are excited wh...

journal_title：Biochemical and biophysical research communications

authors： Fritze W

更新日期：1996-06-14 00:00:00

abstract：:The amino acid sequences in the NH2-terminal region and some other parts of human gastric cathepsin E were investigated. The NH2-terminal sequencing revealed that the cathepsin E preparation which had been activated at pH 4.0 contained one major and one minor isozymes in an approximate molar ratio of 3:1. The NH2-term...

journal_title：Biochemical and biophysical research communications

authors： Athauda SB,Matsuzaki O,Kageyama T,Takahashi K

更新日期：1990-04-30 00:00:00

abstract：:PP2Cgamma is a splicing factor that dephosphorylates specific substrates required for the formation of the spliceosome. In a previous study, we reported that the degradation of p21(Cip1/WAF1)was affected by PP2Cgamma, causing an accumulation of cells in S phase. Here, we demonstrate that the PP2Cgamma-induced degradat...

journal_title：Biochemical and biophysical research communications

authors： Suh EJ,Kim YJ,Kim SH

更新日期：2009-08-28 00:00:00

abstract：:The tyrosine kinase Fms, the cell surface receptor for M-CSF and IL-34, is critical for microglial proliferation and differentiation in the brain. Recently, a number of mutations have been identified in Fms as a putative genetic cause of hereditary diffuse leukoencephalopathy with spheroids (HDLS), implying an importa...

journal_title：Biochemical and biophysical research communications

authors： Hiyoshi M,Hashimoto M,Yukihara M,Bhuyan F,Suzu S

更新日期：2013-11-01 00:00:00

abstract：:To evaluate the role of the sulphated tyrosine residue in position 27 in human cholecystokinin-33, parallel bioassay of the sulphated form of human cholecystokinin-33 and the unsulphated form of human cholecystokinin-33 was performed on the pancreatic protein secretion. Both peptides increased the protein output in a ...

journal_title：Biochemical and biophysical research communications

authors： Doi R,Inoue K,Kogire M,Sumi S,Yun M,Futaki S,Fujii N,Yajima H,Tobe T

更新日期：1988-06-30 00:00:00