Role of sulphated tyrosine residue in influencing the biologic activity of human cholecystokinin-33.

Abstract:

:To evaluate the role of the sulphated tyrosine residue in position 27 in human cholecystokinin-33, parallel bioassay of the sulphated form of human cholecystokinin-33 and the unsulphated form of human cholecystokinin-33 was performed on the pancreatic protein secretion. Both peptides increased the protein output in a dose-related manner. However, the sulphated form possessed a considerably higher activity than the sulphated form. The relative potency of the unsulphated human cholecystokinin-33 compared to that of the sulphated human cholecystokinin-33 (taken as 1.0) was 0.08. From the results, it was suggested that the sulphated tyrosine may play an important role in controlling the activity of the longer molecular forms as well as that of the smaller forms of cholecystokinin.

authors

Doi R,Inoue K,Kogire M,Sumi S,Yun M,Futaki S,Fujii N,Yajima H,Tobe T

doi

10.1016/s0006-291x(88)81356-1

subject

Has Abstract

pub_date

1988-06-30 00:00:00

pages

1209-13

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)81356-1

journal_volume

153

pub_type

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