Abstract:
:To date, tick-borne flaviviruses responsible for hemorrhagic fever in humans have been isolated in Siberia (Omsk hemorrhagic fever virus), India (Kyasanur Forest disease virus, KFDV), and in Saudi Arabia (Alkhurma virus, ALKV). Prior to this study, only partial coding sequences of these severe pathogens had been determined. We report here the complete coding sequence of ALK virus, which was determined to be 10,248 nucleotides (nt) long, and to encode a single 3,416 amino acid polyprotein. Independent analyses of the complete polyprotein and the envelope protein provided genetic and phylogenetic evidence that ALKV belongs to the tick-borne flavivirus group, within which it is most closely related to KFDV. Analysis of structural genes, genetic distances, and evolutionary relationship indicate that ALKV and KFDV derived from a common phylogenetic ancestor and constitute two genetic subtypes of the same virus species according to current genetic criteria of classification.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Charrel RN,Zaki AM,Attoui H,Fakeeh M,Billoir F,Yousef AI,de Chesse R,De Micco P,Gould EA,de Lamballerie Xdoi
10.1006/bbrc.2001.5610subject
Has Abstractpub_date
2001-09-21 00:00:00pages
455-61issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(01)95610-4journal_volume
287pub_type
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