Differential regulation of alpha6beta4 integrin by PKC isoforms in murine skin keratinocytes.

abstract：:53BP1 plays important roles in checkpoint signaling and repair for DNA double-strand breaks. We found that a colon cancer cell line, SW48, expressed a splicing variant form of 53BP1, which lacks the residues corresponding to exons 10 and 11. Activation of ATM and phosphorylation of ATM and ATR targets occurred in SW48...

journal_title：Biochemical and biophysical research communications

authors： Iwabuchi K,Matsui T,Hashimoto M,Matsumoto Y,Kurihara T,Date T

更新日期：2008-11-21 00:00:00

abstract：:Spin-trapping experiments in alkaline aqueous dimethyl sulfoxide (DMSO) solution using sodium 3,5-dibromo-4-nitrosobenzenesulfonate (DBNBS) yielded a strong signal of the sulfur trioxide anion radical adduct. This radical adduct is identical to that obtained by the oxidation of sulfite with horseradish peroxidase/hydr...

journal_title：Biochemical and biophysical research communications

authors： Stolze K,Mason RP

更新日期：1987-03-30 00:00:00

abstract：:Distribution of mRNA expression of 1,25-dihydroxyvitamin D3 receptor (VDR) and 25-hydroxyvitamin D3-24-hydroxylase (24-OHase) along the microdissected rat nephron segments was examined by reverse transcription-polymerase chain reaction (RT-PCR) technique. VDR mRNA was abundantly expressed in cortical segments (glomeru...

journal_title：Biochemical and biophysical research communications

authors： Iida K,Taniguchi S,Kurokawa K

更新日期：1993-07-30 00:00:00

abstract：BACKGROUND:Simvastatin is widely used to lower cholesterol levels in patients with cardiovascular diseases, although accumulating evidence suggests that statins, such as simvastatin, also exert numerous anti-tumoral effects. AIM:The aim of this study was to examine the effect of simvastatin on colon cancer cell migrat...

journal_title：Biochemical and biophysical research communications

authors： Al-Haidari AA,Syk I,Thorlacius H

更新日期：2014-03-28 00:00:00

abstract：:Hemorrhagic snake venom induces apoptosis of vascular endothelial cells [S. Araki, T. Ishida, T. Yamamoto, K. Kaji, and H. Hayashi (1993) Biochem. Biophys. Res. Comm. 190 , 148-153]. We have identified that a cytotoxic substance of Korean snake venom which is responsible for the apoptosis is L-amino acid oxidase (LAO)...

journal_title：Biochemical and biophysical research communications

authors： Suhr SM,Kim DS

更新日期：1996-07-05 00:00:00

abstract：:Putative E2/NS1 sequence of hepatitis C virus was expressed in E. coli as a fusion protein with maltose binding protein. Approximately 80 kDa protein was obtained containing 38 kDa E2/NS1 protein. The antibody to this protein was detectable in the same serum from which the sequence was amplified. It was also detectabl...

journal_title：Biochemical and biophysical research communications

authors： Yokosuka O,Ito Y,Imazeki F,Ohto M,Omata M

更新日期：1992-11-30 00:00:00

abstract：:Akt is one of the critical mediators in cellular signaling, and overactivation of Akt related pathway frequently occurs in hepatocellular carcinoma (HCC). In this study, we presented that Akt was upregulated in HCC cell lines, and its active phosphorylated form was mainly located in the nucleus. Employing the laser co...

journal_title：Biochemical and biophysical research communications

authors： Zhu L,Hu C,Li J,Xue P,He X,Ge C,Qin W,Yao G,Gu J

更新日期：2007-05-18 00:00:00

abstract：:The purpose of this study was to examine whether mechanical tensile forces affect estrogen regulation of collagen synthesis of anterior cruciate ligament fibroblasts at the mRNA level. Estrogen was studied at three physiologic levels, 10(-11), 10(-10), and 10(-9)M. The results revealed that estrogen alone stimulated T...

journal_title：Biochemical and biophysical research communications

authors： Lee CY,Smith CL,Zhang X,Hsu HC,Wang DY,Luo ZP

更新日期：2004-05-14 00:00:00

abstract：:The Sec23p-Sec24p complex is a component of coat protein II-coated vesicles involved in protein export from the endoplasmic reticulum. We previously identified a novel Sec23p-interacting protein, p125, which consists of 1000 amino acids and comprises a proline-rich region and a phospholipase A(1) homology region. p125...

journal_title：Biochemical and biophysical research communications

authors： Mizoguchi T,Nakajima K,Hatsuzawa K,Nagahama M,Hauri HP,Tagaya M,Tani K

更新日期：2000-12-09 00:00:00

abstract：:Incorporation of [14C]serine into phosphatidylserine by the base exchange reaction in Ehrlich ascites tumor cells is inhibited by 30% by glucose and by 60% by 2-deoxyglucose (10 mM each). The inhibition by thapsigargin (0.2 microM) amounts to 80%. This inhibition is interpreted as being due to depletion of calcium sto...

journal_title：Biochemical and biophysical research communications

authors： Rakowska M,Wojtczak L

更新日期：1995-02-06 00:00:00

abstract：:Purified m beta-acrosin catalysed amidolysis in vitro of several p-nitroanilides with C-terminal arginine residues. alpha 1-proteinase inhibitor inhibited amidolysis catalysed by the enzyme. This effect of alpha 1-Proteinase inhibitor was not prevented by pre-incubation of the enzyme with heparin or any other glycosam...

journal_title：Biochemical and biophysical research communications

authors： Long WF,Williamson FB

更新日期：1983-11-30 00:00:00

abstract：:Acetyl-CoA carboxylases (ACCs) have been highlighted as therapeutic targets for obesity and diabetes, as they play crucial roles in fatty acid metabolism. ACC activity is regulated through the short-term mechanism of inactivation by reversible phosphorylation. Here, we report the crystal structures of the biotin carbo...

journal_title：Biochemical and biophysical research communications

authors： Cho YS,Lee JI,Shin D,Kim HT,Jung HY,Lee TG,Kang LW,Ahn YJ,Cho HS,Heo YS

更新日期：2010-01-01 00:00:00

abstract：:Prion diseases are characterized by the accumulation of a pathological form of prion protein (PrP(Sc)), which behaves as an infectious agent. Here we developed an in vitro co-culture system to analyze the PrP(Sc) transmission from ScN2a cell, which persistently retains PrP(Sc), to naïve N2a cell. In this cell-to-cell ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka M,Hara H,Nishina H,Hanada K,Hagiwara K,Maehama T

更新日期：2010-07-02 00:00:00

abstract：:A specific radioimmunoassay was developed for metorphamide, an endogenous, amidated opioid octapeptide, originally isolated from bovine brain and human pheochromocytoma tissues. The radioimmunoassay was used to determine the concentration of immunoreactive metorphamide in extracts from dissected regions of rat and gui...

journal_title：Biochemical and biophysical research communications

authors： Sonders M,Barchas JD,Weber E

更新日期：1984-08-16 00:00:00

abstract：:MK is a gene whose expression increases transiently during retinoic acid-induced differentiation of embryonal carcinoma cells. MK polypeptide was secreted by differentiating HM-1 embryonal carcinoma cells and by L-cells transfected with an MK cDNA under the control of the beta-actin promoter and Rous sarcoma virus enh...

journal_title：Biochemical and biophysical research communications

authors： Tomomura M,Kadomatsu K,Nakamoto M,Muramatsu H,Kondoh H,Imagawa K,Muramatsu T

更新日期：1990-09-14 00:00:00

abstract：:The objective of this study was to assess the role of NETs in BPD of hyperoxia-induced rat model and the effect of heparin on alveolarization and vascular development in BPD. The neonatal rats exposed to 90% oxygen continuously for 7 days to mimic BPD, meanwhile, the rats were injected by different doses of histones t...

journal_title：Biochemical and biophysical research communications

authors： Sun Y,Chen C,Zhang X,Wang S,Zhu R,Zhou A,Chen S,Feng J

更新日期：2020-01-29 00:00:00

abstract：:NF-kappaB family of transcription factors are involved in numerous cellular processes, including differentiation, proliferation, and inflammation. It was reported that hydroxycinnamic acid derivatives (HADs) are inhibitors of NF-kappaB activation. Rice bran oil contains a lot of phytosteryl ferulates, one of HADs. We ...

journal_title：Biochemical and biophysical research communications

authors： Nagasaka R,Chotimarkorn C,Shafiqul IM,Hori M,Ozaki H,Ushio H

更新日期：2007-06-29 00:00:00

abstract：:A voltage-dependent K+ current has been revealed in whole-cell recordings carried out on immortalized cells obtained from the human tracheal epithelium. At positive membrane potentials the current shows a time dependent inactivation which is accelerated by increasing the depolarizing step. Forskolin, a direct activato...

journal_title：Biochemical and biophysical research communications

authors： Galietta LJ,Rasola A,Barone V,Gruenert DC,Romeo G

更新日期：1991-09-30 00:00:00

abstract：:Protein aggregate/inclusion is one of hallmarks for neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). FUS/TLS, one of causative genes for familial ALS, encodes a multifunctional DNA/RNA binding protein predominantly localized in the nucleus. C-terminal mutations in FUS/TLS cause the retention ...

journal_title：Biochemical and biophysical research communications

authors： Takanashi K,Yamaguchi A

更新日期：2014-09-26 00:00:00

abstract：:Ciliogenesis is often impaired in some cancer cells, leading to acceleration of cancer phenotypes such as cell migration and proliferation. From the investigation of primary cilia of 16 gastric cancer cells (GCs), we found that GCs could be grouped into four primary cilia (PC)-positive GCs and 12 PC-negative GCs. The ...

journal_title：Biochemical and biophysical research communications

authors： Jung Y,Cho SM,Kim S,Cheong JH,Kwon HJ

更新日期：2021-02-05 00:00:00

abstract：:Streptococcus pneumoniae is a pathogenic bacterium that can cause severe invasive diseases, such as pneumonia, otitis media and meningitis. The pro-inflammatory cytokine, IL-1β, has been reported to play important role in host defense against S. pneumoniae. The mechanism of IL-1β maturation and secretion in macrophage...

journal_title：Biochemical and biophysical research communications

authors： Zhang T,Du H,Feng S,Wu R,Chen T,Jiang J,Peng Y,Ye C,Fang R

更新日期：2019-06-04 00:00:00

abstract：:Homocysteine is an accepted risk factor when its plasma level exceeds the physiological upper limit of 12 mumol/L. We found in vitro that homocysteine is able to lyse the erythrocytes (RBCs) at higher concentrations than 15 mumol/L only when activated polymorphonuclear leukocytes (PMNL) are present. The hemolytic effe...

journal_title：Biochemical and biophysical research communications

authors： Olinescu R,Kummerow FA,Handler B,Fleischer L

更新日期：1996-09-24 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene's promoter. We have previously demonstrated that VDR binds in vitro with high affinity to the 5'-flanking sequence of...

journal_title：Biochemical and biophysical research communications

authors： Seoane S,Alonso M,Segura C,Pérez-Fernández R

更新日期：2002-03-22 00:00:00

abstract：:Numerous synthetic chemicals have estrogenic activity by interacting with the estrogen receptor. In this report, we test the hypothesis that some estrogenic chemicals may also modulate the human progesterone receptor (hPR) signaling pathway. This was evaluated by examining synthetic chemicals for their ability to modu...

journal_title：Biochemical and biophysical research communications

authors： Tran DQ,Klotz DM,Ladlie BL,Ide CF,McLachlan JA,Arnold SF

更新日期：1996-12-13 00:00:00

abstract：:Chronic infection with hepatitis B virus (HBV) remains an important global health problem. Currently licensed therapies have modest curative efficacy, which is as a result of their transient effects and limited action on the viral replication intermediate comprising covalently closed circular DNA (cccDNA). Gene editin...

journal_title：Biochemical and biophysical research communications

authors： Dreyer T,Nicholson S,Ely A,Arbuthnot P,Bloom K

更新日期：2016-09-30 00:00:00

abstract：:Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+ protect against inactivation and modification, in agreement with the study on E. coli dUTPase (Vertessy et al. ...

journal_title：Biochemical and biophysical research communications

authors： Vertessy BG,Persson R,Rosengren AM,Zeppezauer M,Nyman PO

更新日期：1996-02-15 00:00:00

abstract：:Brain cell-free extract greatly stimulates the polymerization rate of purified tubulin with a reduction of the nucleation period and without a significant alteration of the final assembly state. This effect is mimicked by neuroblastoma extract at 10-fold lower extract concentration, but not by excess muscle extract. C...

journal_title：Biochemical and biophysical research communications

authors： Liliom K,Wágner G,Kovács J,Comin B,Cascante M,Orosz F,Ovádi J

更新日期：1999-10-22 00:00:00

abstract：:Fructosamine-3-kinase (FN3K) and the more recently discovered fructosamine-3-kinase related protein (FN3KRP) appear to protect proteins from nonenzymatic glycation. To elucidate the patterns of transcriptional regulation of these two genes, we performed in silico comparisons of their promoters along with real-time PCR...

journal_title：Biochemical and biophysical research communications

authors： Conner JR,Beisswenger PJ,Szwergold BS

更新日期：2004-10-22 00:00:00

abstract：:Differences in insulin-like growth factor binding proteins (IGFBPs) expressed within estrogen receptor positive (ER+, MCF-7/6) and negative (ER-, MDA-MB-231) human breast cancer cells cultured in chemically defined medium were observed. In the absence of insulin, 17 beta-estradiol affects this expression in ER+ cells ...

journal_title：Biochemical and biophysical research communications

authors： Dubois V,Couissi D,Schonne E,Schneider YJ,Remacle C,Trouet A

更新日期：1993-04-15 00:00:00

abstract：:The Xenopus homologue of sonic hedgehog (Xhh) was detected in Xenopus embryos at stages 13 and 31 by RT-PCR, but it was not expressed in explants isolated from the animal hemisphere of Xenopus embryos at stage 8-9. Treatment of the animal cap with activin (1-100 ng/ml) induced the expression of Xhh. However, it was no...

journal_title：Biochemical and biophysical research communications

authors： Yokotal C,Mukasa T,Higashi M,Odaka A,Muroya K,Uchiyama H,Eto Y,Asashima M,Momoi T

更新日期：1995-02-06 00:00:00