3D structure of the CD26-ADA complex obtained by cryo-EM and single particle analysis.

abstract：:Ambient cold temperature, as an abiotic stress, regulates the survival, stability, transmission, and infection of pathogens. However, the effect of cold temperature on the host receptivity to the pathogens has not been fully studied. In this study, the expression of terminal α-2,3- and α-2,6-sialic acids were increase...

journal_title：Biochemical and biophysical research communications

authors： Moon SC,Joo SY,Chung TW,Choi HJ,Park MJ,Choi HJ,Bae SJ,Kim KJ,Kim CH,Joo M,Ha KT

更新日期：2016-07-29 00:00:00

abstract：:The genetic regulation necessary for the formation of a four-chambered heart is tightly regulated by transcription factors such as TBX20, a member of the T-box (TBX) transcription factor family. TBX20 is critical for proper cardiogenesis and is expressed in the heart throughout development. Missense mutations in TBX20...

journal_title：Biochemical and biophysical research communications

authors： Debenedittis P,Harmelink C,Chen Y,Wang Q,Jiao K

更新日期：2011-06-03 00:00:00

abstract：:Integrin LFA-1 regulates immune cell adhesion and trafficking by binding to ICAM-1 upon chemokine stimulation. Integrin-mediated clutch formation between extracellular ICAM-1 and the intracellular actin cytoskeleton is important for cell adhesion. We applied single-molecule tracking analysis to LFA-1 and ICAM-1 in liv...

journal_title：Biochemical and biophysical research communications

authors： Ishibashi M,Miyanaga Y,Matsuoka S,Kozuka J,Togashi Y,Kinashi T,Ueda M

更新日期：2015-08-21 00:00:00

abstract：:Synthetic block copolymers composed of polyoxyethylene and poly-oxypropylene have been demonstrated to possess ionophore activity selective for monovalent cations and to cause histamine release from mouse mast cells and human basophils. We now report calcium-dependent release of granule contents from human neutrophils...

journal_title：Biochemical and biophysical research communications

authors： Atkinson P,Berkow RL

更新日期：1989-08-30 00:00:00

abstract：:The infection of CHIKV is associated with cellular membranes; however whether early secretory pathways are involved in CHIKV replication remains unclear. In the present study, we have provided initial evidences that CHIKV requires both COPI and COPII for its replication. Small interfering RNAs against COPI components,...

journal_title：Biochemical and biophysical research communications

authors： Zhang N,Zhang L

更新日期：2017-11-25 00:00:00

abstract：:Cytokines represent a multi-diverse family of polypeptide regulators; they are of relatively low molecular weight, pharmacologically active proteins that are secreted by one cell for the purpose of altering either its own functions (autocrine effect) or those of adjacent cells (paracrine effect). Cytokines are small, ...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2002-10-04 00:00:00

abstract：:Changes in proteasome activities were observed during starfish oocyte maturation induced by a maturation-inducing hormone, 1-methyladenine. Succinyl-Leu-Leu-Val-Tyr-MCA-hydrolyzing proteasome activity in immature oocytes showed a main peak of a 1500-kDa fraction and a shoulder centered at a 650-kDa fraction on Superos...

journal_title：Biochemical and biophysical research communications

authors： Sawada MT,Morinaga C,Izumi K,Sawada H

更新日期：1999-01-19 00:00:00

abstract：:The cellular actions of nerve growth factor (NGF) involve regulation of protein phosphorylation. In PC-12 pheochromocytoma cells, exposure of [125I]NGF followed by crosslinking indicates that the ligand binds to two discreet receptors, the previously described 75 kd protein, as well as the trk proto-oncogene product p...

journal_title：Biochemical and biophysical research communications

authors： Ohmichi M,Decker SJ,Pang L,Saltiel AR

更新日期：1991-08-30 00:00:00

abstract：:Recombinant human GM-CSF (rhGM-CSF) from yeast has been clinically applied to immunosuppressed patients. The production of suspension-cultured rice-cell-derived rhGM-CSF (rrhGM-CSF), which has a longer blood clearance time and the same bioactivity as yeast-derived rhGM-CSF, and the analysis of its N-glycans have been ...

journal_title：Biochemical and biophysical research communications

authors： Kim J,Park H,Park BT,Hwang HS,Kim JI,Kim DK,Kim HH

更新日期：2016-10-14 00:00:00

abstract：:Human apoprotein(apo) CI and apo AII cDNA probes have been used to analyze the segregation of the human genes in panels of human-mouse hybrids. The apo CI (APOCI) gene segregates with chromosome 19 and the apo AII (APOA2) gene with chromosome 1. Somatic cell hybrids containing chromosome translocations were used to ma...

journal_title：Biochemical and biophysical research communications

authors： Knott TJ,Eddy RL,Robertson ME,Priestley LM,Scott J,Shows TB

更新日期：1984-11-30 00:00:00

abstract：:It is well known that the expression of osteocalcin, the only recognized osteoblast-specific protein, is regulated by 1 alpha-25-dihydroxyvitamin D3 through a distinct vitamin D3 receptor and a cis-acting DNA response element. In addition, recent data obtained with plasmid constructs have shown a positive interaction ...

journal_title：Biochemical and biophysical research communications

authors： Oliva A,Della Ragione F,Fratta M,Marrone G,Palumbo R,Zappia V

更新日期：1993-03-31 00:00:00

abstract：:It has been suggested that the positive inotropic effect of the vasoactive peptide hormone, endothelin-1 (ET-1), involves inhibition of cardiac K(+) currents. In order to identify the K(+) currents modulated by ET-1, the outward K(+) currents of isolated rat ventricular myocytes were investigated using whole-cell patc...

journal_title：Biochemical and biophysical research communications

authors： James AF,Ramsey JE,Reynolds AM,Hendry BM,Shattock MJ

更新日期：2001-06-22 00:00:00

abstract：:Multidrug resistance (MDR) cells can be sensitized to anticancer drugs when treated concomitantly with chemosensitizers. In this study, chemosensitizing effects of 5,6,7,3',4'-pentamethoxyflavone (sinensetin) and its analogs were investigated with respect to in vitro efficacy and structure-activity relationship. Sinen...

journal_title：Biochemical and biophysical research communications

authors： Choi CH,Sun KH,An CS,Yoo JC,Hahm KS,Lee IH,Sohng JK,Kim YC

更新日期：2002-07-26 00:00:00

abstract：OBJECTIVE:This study aimed to evaluate functions of APOBEC3F gene in biological process of hepatocellular carcinoma (HCC) and anti-tumor mechanisms of bufalin. METHODS:Effect of APOBEC3F and bufalin on cell proliferation and migration abilities were evaluated by CCK-8, wounding healing tests and transwell assays in SK...

journal_title：Biochemical and biophysical research communications

authors： Yang Z,Tao Y,Xu X,Cai F,Yu Y,Ma L

更新日期：2018-09-10 00:00:00

abstract：:In cells, there exists a delicate balance between accumulation of charged metal cations and abundant anionic complexes such as phosphate. When phosphate metabolism is disrupted, cell-wide spread disturbances in metal homeostasis may ensue. The best example is a yeast pho80 mutant that hyperaccumulates phosphate and as...

journal_title：Biochemical and biophysical research communications

authors： Rosenfeld L,Culotta VC

更新日期：2012-02-10 00:00:00

abstract：:HMGB1 is a conserved chromosomal protein composed of two DNA-binding domains and an acidic C-terminal tail. There were evidences suggesting that the C-terminal tail contributed to the DNA binding specificity of the N-terminal DNA-binding domains. However, the mechanism underlining this observation is largely unknown. ...

journal_title：Biochemical and biophysical research communications

authors： Wang Q,Zeng M,Wang W,Tang J

更新日期：2007-08-17 00:00:00

abstract：:Adult height (stature), as an important parameter of human physical development, has been studied in many populations. Recently, we reported a whole genome scan of height on a sample of 630 Caucasian subjects from 53 human pedigrees. Two chromosome regions, 6q24-25 and 7q31.3-36, achieved low linkage signals (multipoi...

journal_title：Biochemical and biophysical research communications

authors： Yang YJ,Liu YZ,Li MX,Lei SF,Chen XD,Sun X,Deng HW

更新日期：2005-10-07 00:00:00

abstract：:Two peptide analogs of the 37-62 sequence region of the HIV TAT protein bind tightly to the surface of A431 breast carcinoma cells. After conjugation to either of two poorly internalized anti-tumor antibody Fab fragments, the analogs enhanced the in vitro cell surface retention and internalization of the Fab fragments...

journal_title：Biochemical and biophysical research communications

authors： Anderson DC,Nichols E,Manger R,Woodle D,Barry M,Fritzberg AR

更新日期：1993-07-30 00:00:00

abstract：:F(ab')2 fragments of anti-CD9 mAb aggregate platelets by a thromboxane-dependent pathway implicating CD9 as signal initiating molecule. We demonstrate that mAbs directed against CD9, but not against GPIIb/IIIa specifically immunoprecipitate, from detergent lysates of human platelets, proteins of 25 and 26 kDa which bi...

journal_title：Biochemical and biophysical research communications

authors： Seehafer JG,Shaw AR

更新日期：1991-08-30 00:00:00

abstract：:Based on the high level of identity among human, mouse, and rat MRP1 protein sequence, we produced a specific polyclonal antibody (MRP1-A23) against a synthetic polypeptide covering the C-terminus of the human protein. Western blot analysis showed a reactivity against human MRP1 similar to that obtained with the monoc...

journal_title：Biochemical and biophysical research communications

authors： Fernetti C,Pascolo L,Podda E,Gennaro R,Stebel M,Tiribelli C

更新日期：2001-11-09 00:00:00

abstract：:A novel human GPCR gene was cloned by PCR with degenerate primers designed from cannabinoid type 1 receptor (CB1) sequences and a full-length clone was isolated by screening of a human genomic DNA library. This gene, termed EDG-3, is highly homologous (51.9 % overall and 69.2 % in seven transmembrane regions) to human...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi F,Tokuda M,Hatase O,Brenner S

更新日期：1996-10-14 00:00:00

abstract：:MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of...

journal_title：Biochemical and biophysical research communications

authors： Novakova J,Slaby O,Vyzula R,Michalek J

更新日期：2009-08-14 00:00:00

abstract：:Comparative fluorimetric studies on the long-term (8-hour) action of beta[1-42]amyloid and its shorter fragments beta[1-40], beta[25-35] and beta[31-35] on the steady-state intracellular Ca2+ concentration in primary cultures of rat astroglial cells using the Ca2+-sensitive fluorescent probe Fura-2 AM revealed higher ...

journal_title：Biochemical and biophysical research communications

authors： Laskay G,Zarándi M,Varga J,Jost K,Fónagy A,Torday C,Latzkovits L,Penke B

更新日期：1997-06-27 00:00:00

abstract：:There are data suggesting that HMG1 protein may be involved in DNA replication. Recently we have found that only the acetylated form of the protein generates tetramers, stimulates the activity of DNA polymerase alpha (EC 2.7.7.7) (with activated DNA as a template) and forms a specific complex with it. This paper compa...

journal_title：Biochemical and biophysical research communications

authors： Dimov SI,Alexandrova EA,Beltchev BG

更新日期：1990-01-30 00:00:00

abstract：:Although the flexural rigidity of a microtubule has previously been estimated by various methods, its temperature dependence has never been systematically examined. Here, we measured the flexural rigidity of a single taxol-stabilized microtubule from thermal fluctuation of the free end of a microtubule, the other end ...

journal_title：Biochemical and biophysical research communications

authors： Kawaguchi K,Ishiwata S,Yamashita T

更新日期：2008-02-15 00:00:00

abstract：:Fe-NTA is a known renal carcinogen. However, little is known about its carcinogenic potential in liver. In this study we for the first time show that Fe-NTA is a potent hepatic tumor promoter. Fe-NTA administration induced dose dependently the hepatic ornithine decarboxylase (ODC) activity several folds as compared to...

journal_title：Biochemical and biophysical research communications

authors： Iqbal M,Giri U,Athar M

更新日期：1995-07-17 00:00:00

abstract：:Caspase-8 is a key mediator in various biological processes such as apoptosis, necroptosis, inflammation, T/B cells activation, and cell motility. Caspase-8 is characterized by the N-terminal tandem death effector domains (DEDs) and the C-terminal catalytic protease domain. The DEDs mediate diverse functions of caspas...

journal_title：Biochemical and biophysical research communications

authors： Shen C,Yue H,Pei J,Guo X,Wang T,Quan JM

更新日期：2015-07-31 00:00:00

abstract：:In this study, we examined the endothelin (ET) receptor subtype involved in mitogenic signaling in human primary and metastatic melanoma cell lines. In a reverse transcriptase-polymerase chain reaction (RT-PCR) study, ET(B) mRNA expression in metastatic melanoma cells was decreased from that of primary melanoma. Only ...

journal_title：Biochemical and biophysical research communications

authors： Kikuchi K,Nakagawa H,Kadono T,Etoh T,Byers HR,Mihm MC,Tamaki K

更新日期：1996-02-27 00:00:00

abstract：:We examined the expression of dystrophin mRNA and the protein in the developing rat heart with polymerase chain reaction, immunoblotting and immunohistochemical analyses. Dystrophin mRNA was detectable on and after the 10th embryonic day, while the protein became detectable during the perinatal period. ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka H,Ozawa E

更新日期：1990-10-30 00:00:00

abstract：:Satellite cells that reside on the myofibre surface are crucial for the muscle homeostasis and regeneration. Aging goes along with a less effective regeneration of skeletal muscle tissue mainly due to the decreased myogenic capability of satellite cells. This phenomenon impedes proper maintenance and contributes to th...

journal_title：Biochemical and biophysical research communications

authors： Di Filippo ES,Mancinelli R,Pietrangelo T,La Rovere RM,Quattrocelli M,Sampaolesi M,Fulle S

更新日期：2016-04-29 00:00:00