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Effect of retinoic acid on osteocalcin gene expression in human osteoblasts.

Abstract：

:It is well known that the expression of osteocalcin, the only recognized osteoblast-specific protein, is regulated by 1 alpha-25-dihydroxyvitamin D3 through a distinct vitamin D3 receptor and a cis-acting DNA response element. In addition, recent data obtained with plasmid constructs have shown a positive interaction between retinoic acid activated receptor(s) and the osteocalcin gene promoter. Our studies, carried out on primary cultures of human osteoblasts, have demonstrated for the first time the activation of the osteocalcin gene expression by retinoic acid. Moreover, a remarkable synergistic effect between the hormonal forms of vitamin A and D3 on the synthesis of this bone-specific protein was observed.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Oliva A,Della Ragione F,Fratta M,Marrone G,Palumbo R,Zappia V

doi

10.1006/bbrc.1993.1303

subject

Has Abstract

pub_date

1993-03-31 00:00:00

pages

908-14

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X83713033

journal_volume

191

pub_type

杂志文章

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