BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

abstract：:A p60K protein in human colon adenocarcinoma tumor cell lines was identified as a myristoylated pp60c-src by fluorography and radioimmunoprecipitation analysis. Prevention of the myristoylation of pp60c-src was determined with N-fatty acyl glycinal compounds. Of the compounds tested, N-myristoyl glycinal diethylacetal...

journal_title：Biochemical and biophysical research communications

authors： Shoji S,Kurosawa T,Inoue H,Funakoshi T,Kubota Y

更新日期：1990-12-31 00:00:00

abstract：:The cytosolic sulfotransferases (SULTs) in vertebrates catalyze the sulfonation of endogenous thyroid/steroid hormones and catecholamine neurotransmitters, as well as a variety of xenobiotics, using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as the sulfonate donor. In this study, we determined the structures of SULT...

journal_title：Biochemical and biophysical research communications

authors： Lu J,Li H,Zhang J,Li M,Liu MY,An X,Liu MC,Chang W

更新日期：2010-05-28 00:00:00

abstract：:Binding of cytochrome b5 to rat cytochrome P450 2B1 was inhibited (by 75%) by a synthetic peptide corresponding to P450 residues 116-134. The role of Lys-122 and Arg-125 were evaluated using peptides in which one or both of these basic residues were replaced with Glu. The Lys-122 substitution nearly abolished while th...

journal_title：Biochemical and biophysical research communications

authors： Omata Y,Sakamoto H,Robinson RC,Pincus MR,Friedman FK

更新日期：1994-06-30 00:00:00

abstract：:We previously reported that novel targeted "hybrid peptide" in which epidermal growth factor receptor (EGFR) binding peptide was conjugated with lytic-type peptide had selective cytotoxic activity to EGFR expressing cancer cell lines, and in vivo analysis revealed that this EGFR-lytic peptide displayed significant ant...

journal_title：Biochemical and biophysical research communications

authors： Tada N,Horibe T,Haramoto M,Ohara K,Kohno M,Kawakami K

更新日期：2011-04-08 00:00:00

abstract：:The influence of collagen as an effective substitute for gelatin was investigated on properties of chitosan/gelatin hydrogels for fibroblasts growth and attachment for wound dressing applications. We synthesized hydrogels based on chitosan associated with collagen and gelatin biopolymers (in the ratio of 1:5 and 1:1, ...

journal_title：Biochemical and biophysical research communications

authors： Mousavi S,Khoshfetrat AB,Khatami N,Ahmadian M,Rahbarghazi R

更新日期：2019-10-22 00:00:00

abstract：:We have obtained two new mAbs to the carboxy-terminal region of fibronectin, namely P3D4 and P1F11, and have studied their binding sites and their ability to block lymphocyte adhesion to fibronectin. ELISA and Western blot analyses showed that P3D4 reacts with both fibronectin chains and both Hep II-containing fragmen...

journal_title：Biochemical and biophysical research communications

authors： Garcia-Pardo A,Sánchez-Aparicio P,Wayner EA

更新日期：1992-07-15 00:00:00

abstract：:Glycogen-storage disease type II (GSD II, acid maltase deficiency, Pompe's disease) is caused by defects in the lysosomal acid alpha-glucosidase (GAA) gene. Clinically, patients with the severe infantile form of GSD II have muscle weakness and cardiomyopathy eventually leading to death before the age of two years. Pat...

journal_title：Biochemical and biophysical research communications

authors： Nicolino M,Puech JP,Letourneur F,Fardeau M,Kahn A,Poenaru L

更新日期：1997-06-09 00:00:00

abstract：:Phosphorylation influences DNA binding and transactivator capabilities of multiple transcription factors. In this study, we demonstrate that the POU-domain transcription factor, Oct-3, can be phosphorylated in vivo. In addition, we show that in COS-1 cells Oct-3 is phosphorylated exclusively on serine residues. Lastly...

journal_title：Biochemical and biophysical research communications

authors： Rosfjord E,Scholtz B,Lewis R,Rizzino A

更新日期：1995-07-26 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) have played very important roles in the malignancy behaviors of hepatocellular carcinoma (HCC). Linc-cdh4-2 (TCONS_00027978) is a novel LncRNA that has been identified in HCC tissues from our previous study. Overexpression of linc-cdh4-2 in HCC cell lines (SK-Hep-1 and Huh7) significantl...

journal_title：Biochemical and biophysical research communications

authors： Gao Y,Wang G,Zhang C,Lin M,Liu X,Zeng Y,Liu J

更新日期：2016-11-18 00:00:00

abstract：:We have previously reported that salmosin, a novel disintegrin, was isolated from Korean snake (Agkistrodon halys brevicaudus) venom and significantly inhibited solid tumor growth in mice by perturbation of tumor-specific angiogenesis via blocking alphavbeta3 integrin expressed on vascular endothelial cells. In this s...

journal_title：Biochemical and biophysical research communications

authors： Kang IC,Kim DS,Jang Y,Chung KH

更新日期：2000-08-18 00:00:00

abstract：:CD40-mediated signals can induce cell aggregation, proliferation and rescue from apoptosis in WEHI231. To define which segment of cytoplasmic domain of CD40 and how signals are involved in those events, we generated mutant CD40 transfectants. We demonstrated the same 10 amino acid segment that could bind to tumor necr...

journal_title：Biochemical and biophysical research communications

authors： Hara T,Murakami M,Maeda H,Hibi M,Uede T

更新日期：1997-04-07 00:00:00

abstract：:A novel hemoglobin variant was detected by electrospray ionization mass spectrometry. Hb Zurich-Hottingen is characterized by an Asn --> Ser replacement in the alpha-chain at position 9 as confirmed by DNA analysis. This hemoglobin variant is silent in isoelectric focusing, reversed-phase chromatography, and cation-ex...

journal_title：Biochemical and biophysical research communications

authors： Troxler H,Neuheiser F,Kleinert P,Kuster T,Heizmann CW,Sack R,Hunziker P,Neuhaus TJ,Schmid M,Frischknecht H

更新日期：2002-04-12 00:00:00

abstract：:Tau, a microtubule-associated phosphoprotein, was identified as a definite component of paired helical filaments which progressively accumulate in Alzheimer's disease brain. To learn more about tau in the aged brain, we have isolated and sequenced a cDNA clone encoding tau from a cDNA library of an aged human brain. T...

journal_title：Biochemical and biophysical research communications

authors： Mori H,Hamada Y,Kawaguchi M,Honda T,Kondo J,Ihara Y

更新日期：1989-03-31 00:00:00

abstract：:Human hepatocarcinoma Hep G2 cells were grown in culture medium containing [45Ca2+]. The secreted lipoproteins of d less than 1.063 g/ml and d 1.063-1.21 g/ml were isolated from the culture media and analyzed by 3.3% and 7% SDS-polyacrylamide gel electrophoresis. Radioactivity profiles of [45Ca] from the gels showed t...

journal_title：Biochemical and biophysical research communications

authors： Dashti N,Lee DM,Mok T

更新日期：1986-05-29 00:00:00

abstract：:The complex of immobilized human plasminogen (iHPlg) and streptokinase (SK) has a lower catalytic activity in hydrolysis of plasmin-specific substrate S-2251 with a kcat/Km of 0.005 microM-1 x s-1, compared to 0.031 microM-1 x s-1 of immobilized human plasmin (iHPlm) and 0.078 microM-1 x s-1 of HPlm. The SK in the com...

journal_title：Biochemical and biophysical research communications

authors： Shi GY,Chang BI,Wu DH,Wu HL

更新日期：1993-08-31 00:00:00

abstract：:Bone homeostasis is maintained by bone remodeling, which involves continuous bone resorption by osteoclasts and bone formation by osteoblasts. Dysregulation of bone turnover, caused by osteoclast overactivation, causes destructive bone diseases. However, the mechanisms underlying the maintenance of osteoclast differen...

journal_title：Biochemical and biophysical research communications

authors： Aoki S,Shimizu K,Ito K

更新日期：2020-07-05 00:00:00

abstract：:Glycogen phosphorylase (a or b) binds 125I-calmodulin in a Ca2+-dependent manner, in the 125I-calmodulin overlay technique. This binding is quantitatively identical to 125I-calmodulin binding to myosin light chain kinase. In an in vitro assay, calmodulin stimulates phosphorylase activity at limiting concentrations of ...

journal_title：Biochemical and biophysical research communications

authors： Slaughter GR,Means AR

更新日期：1985-01-16 00:00:00

abstract：:MicroRNAs (miRNAs) play crucial roles in the pancreatic carcinogenesis and progression. In the present study, we found that miR-9-5p was significantly downregulated in pancreatic cancer tissues and cell lines. The expression levels of miR-9-5p were negatively correlated with tumor stage and vessel invasion. Log-rank t...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Wang B,Ren H,Chen W

更新日期：2019-01-29 00:00:00

abstract：:Arctigenin is a bioactive constituent from dried seeds of Arctium lappa L., which was traditionally used as medicine. Arctigenin exhibits various bioactivities, but its effects on blood pressure regulation are still not widely studied. In this study, we investigated antihypertensive effects of arctigenin by long-term ...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Wang G,Yang M,Chen H,zhao Y,Yang S,Sun C

更新日期：2015-12-25 00:00:00

abstract：:The tailspike protein (TSP) of bacteriophage P22 is a homotrimeric multifunctional protein responsible for recognition and hydrolysis of Salmonella typhimurium host receptors. Once properly folded, TSP shows an unusual stability to temperature and detergent denaturation, prompting the analysis of TSP as a framework fo...

journal_title：Biochemical and biophysical research communications

authors： Carbonell X,Villaverde A

更新日期：1998-03-17 00:00:00

abstract：:To understand the regulation by thyroid hormone, 3,3',5-triiodo-L-thyronine (T3), of the synthesis of a cytosolic thyroid hormone binding protein (p58-M2) during liver regeneration, the synthesis of p58-M2 was evaluated. The synthesis of p58-M2 was measured by metabolic labeling of primary cultures derived from the re...

journal_title：Biochemical and biophysical research communications

authors： Obata T,Cheng SY

更新日期：1992-11-30 00:00:00

abstract：:Neu2 mRNA from the mouse thymus, as we have reported [K. Kotani, A. Kuroiwa, T. Saito, Y. Matsuda, T. Koda, S. Kijimoto-Ochiai, Cloning, chromosomal mapping, and characteristic 5'-UTR sequence of murine cytosolic sialidase, Biochem. Biophys. Res. Commun. 286 (2001) 250-258], has a novel sequence at the 5' terminus tha...

journal_title：Biochemical and biophysical research communications

authors： Koda T,Kijimoto-Ochiai S,Uemura S,Inokuchi J

更新日期：2009-10-02 00:00:00

abstract：:Histone lysine N-methyltransferase 2D (KMT2D), an important methyltransferase that is involved in the methylation of lysine 4 in histone H3 (H3K4) and related to the development of prostate cancer. Hypermethylation of H3K4 is shown in prostate cancer (PCa). However, KMT2D inhibitors have not yet been developed. This a...

journal_title：Biochemical and biophysical research communications

authors： Yu Q,Liao Z,Liu D,Xie W,Liu Z,Liao G,Wang C

更新日期：2020-12-10 00:00:00

abstract：:Serum transferrin (tf), encoding an iron-binding glycoprotein, has been revealed to play important roles in iron transportation and immune response, and it also has been demonstrated to be valuable for phylogenetic analysis in vertebrates. However, the evolutionary conservation, expression profiles and positive select...

journal_title：Biochemical and biophysical research communications

authors： Liu XL,Wang YK,Ouyang S,Zhu YY,Li W,Hong XY,Xu HY,Zhu XP

更新日期：2018-12-02 00:00:00

abstract：:A rat gene with testis-specific expression coinciding with spermatogenesis was cloned by differential display. This spermatogenesis-related factor-1 (SRF-1) gene was not expressed in other organs. Testicular expression was detected from 5 weeks of age and increased up to 15 weeks; this level of expression was maintain...

journal_title：Biochemical and biophysical research communications

authors： Yamano Y,Ohyama K,Sano T,Ohta M,Shimada A,Hirakawa Y,Sugimoto M,Morishima I

更新日期：2001-12-14 00:00:00

abstract：:The effects of fibroblast growth factor (FGF) on testicular aromatase activity has been studied using primary cultures of porcine Leydig cells. After culture for 3 days in the absence or presence of FGF, the ability of the cells to produce estrogen was examined in a 4h-test period in which either (a) hCG (10(-9) M) or...

journal_title：Biochemical and biophysical research communications

authors： Raeside JI,Berthelon MC,Sanchez P,Saez JM

更新日期：1988-02-29 00:00:00

abstract：:Amphibian skin contains rich bradykinin-related peptides, but the mode of biosynthesis of these peptides is unknown. In the present study, a novel bradykinin-related peptide, termed bombinakinin M, was purified from skin secretions of the Chinese red belly toad Bombina maxima. Its primary sequence was established as D...

journal_title：Biochemical and biophysical research communications

authors： Lai R,Liu H,Hui Lee W,Zhang Y

更新日期：2001-08-17 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptide in the brain, which is produced by the proteolysis of β-amyloid precursor protein (APP). Recently, the mitochondrial transcription factor 4 (MTERF4), a member of the MTERF family, was implicated in regulating mitochondrial DNA transc...

journal_title：Biochemical and biophysical research communications

authors： Wang XL,Liu Q,Chen GJ,Li ML,Ding YH

更新日期：2017-01-22 00:00:00

abstract：:Leukaemia inhibitory factor (LIF) was the first soluble factor identified as having potential to maintain the pluripotency of mouse embryonic stem (ES) cells. Recently, a second factor, Wnt, with similar activity was found. However, the relationship between these completely different signals mediating the overlapping ...

journal_title：Biochemical and biophysical research communications

authors： Ogawa K,Nishinakamura R,Iwamatsu Y,Shimosato D,Niwa H

更新日期：2006-04-28 00:00:00

abstract：:Bacteriorhodopsin (BR) was reconstituted into artificial lipid membrane containing various charged lipid compositions. The proton pumping activity of BR under flash and continuous illumination, proton permeability across membrane, as well as the decay kinetics of the photocycle intermediate M(412) were studied. The re...

journal_title：Biochemical and biophysical research communications

authors： Wang Z,Bai J,Xu Y

更新日期：2008-07-11 00:00:00