A novel spermatogenesis-related factor-1 gene expressed in maturing rat testis.

abstract：:Bovine myocardial sarcolemma and sarcoplasmic reticulum vesicle preparations contained calcium-dependent protease inhibitor protein. No inhibitor was detected in mitochondrial membranes. The membrane-bound inhibitor co-purified with the marker enzymes for sarcolemma and sarcoplasmic reticulum, Na+,K+-ATPase and Ca2+,K...

journal_title：Biochemical and biophysical research communications

authors： Mellgren RL,Lane RD,Kakar SS

更新日期：1987-02-13 00:00:00

abstract：:Expression of bone-associated proteins and osteoblastic transcription factor Runx2 in arterial cells has been implicated in the development of vascular calcification. However, the signaling upstream of the Runx2-mediated activation of osteoblastic program in vascular smooth muscle cells (VSMC) is poorly understood. We...

journal_title：Biochemical and biophysical research communications

authors： Nakahara T,Sato H,Shimizu T,Tanaka T,Matsui H,Kawai-Kowase K,Sato M,Iso T,Arai M,Kurabayashi M

更新日期：2010-04-02 00:00:00

abstract：:Starch branching enzyme (SBE) catalyzes the cleavage of α-1,4-linkages and the subsequent transfer of α-1,4 glucan to form an α-1,6 branch point in amylopectin. We determined the crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose at a resolution of 2.2Å. Maltopentaose bound to a hydro...

journal_title：Biochemical and biophysical research communications

authors： Chaen K,Noguchi J,Omori T,Kakuta Y,Kimura M

更新日期：2012-08-03 00:00:00

abstract：:Glutamate-mediated excitotoxicity is involved in many acute and chronic brain diseases. Dynamin related protein 1 (Drp-1), one of the GTPase family of proteins that regulate mitochondrial fission and fusion balance, is associated with apoptotic cell death in cancer and neurodegenerative diseases. Here we investigated ...

journal_title：Biochemical and biophysical research communications

authors： Zhang C,Yuan XR,Li HY,Zhao ZJ,Liao YW,Wang XY,Su J,Sang SS,Liu Q

更新日期：2014-01-03 00:00:00

abstract：:Intestinal brush border membranes prepared from pig jejunum were shown to transport intact reduced glutathione into an osmotically responsive intravesicular space. At early incubation time (under 1 min.) GSH was poorly hydrolysed in its free amino acids. Primarily glutathione uptake was obtained against a concentratio...

journal_title：Biochemical and biophysical research communications

authors： Linder M,De Burlet G,Sudaka P

更新日期：1984-09-28 00:00:00

abstract：:An exposure of a human myeloma cell line to 2-difluoromethylornithine the mechanism-based inhibitor of ornithine decarboxylase (EC 4.1.1.17), resulted in a selection of tumor cells readily growing in the presence of 4 mM difluoromethylornithine, a concentration that swiftly halted the growth of the parental cells. Det...

journal_title：Biochemical and biophysical research communications

authors： Alhonen-Hongisto L,Leinonen P,Laine R,Jänne J

更新日期：1987-04-14 00:00:00

abstract：:Recent reports have shown that the endoplasmic reticulum (ER) stress is relevant to the pathogenesis of Alzheimer disease. Following the amyloid cascade hypothesis, we therefore attempted to investigate the effects of ER stress on amyloid-beta peptide (Abeta) generation. In this study, we found that ER stress altered ...

journal_title：Biochemical and biophysical research communications

authors： Kudo T,Okumura M,Imaizumi K,Araki W,Morihara T,Tanimukai H,Kamagata E,Tabuchi N,Kimura R,Kanayama D,Fukumori A,Tagami S,Okochi M,Kubo M,Tanii H,Tohyama M,Tabira T,Takeda M

更新日期：2006-06-02 00:00:00

abstract：:Liposome-encapsulated clodronate (LEC) is a specific depletor of macrophages. Our study characterized the LEC depletory effects, given intrathecally, on spinal microglia and assessed its effects on initiation and maintenance of neuropathic pain. Measured by using the MTT assay, LEC treatment specifically inhibited cel...

journal_title：Biochemical and biophysical research communications

authors： Wang YR,Mao XF,Wu HY,Wang YX

更新日期：2018-05-15 00:00:00

abstract：:Missense mutations in the enzyme, glycine N-methyltransferase (GNMT) have been shown to be one cause of persistent isolated hypermethioninaemia in humans. These mutations were first identified by metabolite analysis and were shown to be L49P, N140S, and H176N by gene sequencing. Here we report the kinetic and conforma...

journal_title：Biochemical and biophysical research communications

authors： Luka Z,Wagner C

更新日期：2003-12-26 00:00:00

abstract：:Electrofocusing of mouse small intestine mucosal cytosol yielded two prominent peaks of glutathione S-transferase activity, at pH 8.7 and pH 9.0. These intestinal transferases were indistinguishable from corresponding liver transferases in immunological reactivities and in several other properties. Dietary t-butyl-4-h...

journal_title：Biochemical and biophysical research communications

authors： Parchment RE,Benson AM

更新日期：1984-03-30 00:00:00

abstract：:c-Fes plays pivotal roles in angiogenic cellular responses of endothelial cells. Here we examined the role of c-Fes in vascular endothelial growth factor-A (VEGF-A)-mediated signaling pathways in endothelial cells. We introduced either wild-type or kinase-inactive c-Fes in porcine aortic endothelial (PAE) cell lines, ...

journal_title：Biochemical and biophysical research communications

authors： Kanda S,Mochizuki Y,Miyata Y,Kanetake H

更新日期：2003-07-11 00:00:00

abstract：:The aim of current study was to elucidate whether aquaporin-9 (AQP9) expression was involved in the progression of bone loss induced by microgravity. We used the hind-limb suspension (HLS) mice model to simulate microgravity and induce bone loss. It was found that HLS exposure decreased femur bone mineral density (BMD...

journal_title：Biochemical and biophysical research communications

authors： Bu G,Shuang F,Wu Y,Ren D,Hou S

更新日期：2012-03-23 00:00:00

abstract：:Lymphokine and hematopoietic growth factors control the differentiation and proliferation of diverse cell types by binding to specific cell-surface receptors. Strikingly, the recently elucidated sequences of the interleukin-6 and erythropoietin receptors, and the interleukin-2 receptor beta-chain (p75), display a sign...

journal_title：Biochemical and biophysical research communications

authors： Bazan JF

更新日期：1989-10-31 00:00:00

abstract：:The physiologically active form of vitamin D, 1,25-dihydroxyvitamin D(3), plays an important role not only in the establishment and maintenance of calcium metabolism, but also in regulating cell growth and differentiation. Because the clinical usefulness of 1,25-dihydroxyvitamin D(3) is limited by its tendency to caus...

journal_title：Biochemical and biophysical research communications

authors： Gaschott T,Steinmeyer A,Steinhilber D,Stein J

更新日期：2002-01-11 00:00:00

abstract：:We have discovered two new exons in the mouse fibroblast growth factor 2 (FGF-2 or bFGF) gene that can be alternatively spliced to the second coding exon of the gene. The newly identified exons 1b and 1c are located at, respectively, approximately 19 and 32 kb downstream of the canonical exon 1a. Using RT-PCR analysis...

journal_title：Biochemical and biophysical research communications

authors： Dirks RP,Potter SJ,Griep AE

更新日期：2001-10-05 00:00:00

abstract：:Genes for the human vacuolar type H(+)-ATPase proteolipid (16-kDa) subunit were cloned and their nucleotide sequences were determined. Comparison of the deduced sequences indicated that at least four genes including pseudogenes are present in the human genome. One of them corresponded to that for the 16-kDa subunit ex...

journal_title：Biochemical and biophysical research communications

authors： Hasebe M,Hanada H,Moriyama Y,Maeda M,Futai M

更新日期：1992-03-16 00:00:00

abstract：:Surgery and chemotherapy are the gold-standard treatments for ovarian cancer. The major cause of treatment failure in patients with ovarian cancer is tumoral heterogeneity and drug resistance. Paclitaxel (PTX) is one of the most commonly used first-line drugs for ovarian cancer chemotherapy. Unfortunately, the mechani...

journal_title：Biochemical and biophysical research communications

authors： Hong X,Li S,Li W,Xie M,Wei Z,Guo H,Wei W,Zhang S

更新日期：2019-01-15 00:00:00

abstract：:Diaminopimelate (DAP) epimerase catalyzes the stereoinversion of ll-DAP to meso-DAP, a precursor of l-lysine and an essential component of the bacterial peptidoglycan. This function is vital to bacteria and the enzyme therefore represents an attractive target for the design of novel anti-bacterials. DAP epimerase belo...

journal_title：Biochemical and biophysical research communications

authors： Pillai B,Cherney M,Diaper CM,Sutherland A,Blanchard JS,Vederas JC,James MN

更新日期：2007-11-23 00:00:00

abstract：:We determined the existence and role of beta(2)-adrenergic receptor in cultured BAECs through the effect of a beta-blocker having NO releasing action; 3,4-dihydro-8(2-hydroxy-3-isopropylamino)-propoxy-3-nitroxy-2H-1-benzopyran; nipradilol on eNOS and eNOS regulatory protein caveolin-1. beta(2) receptor exists in BAECs...

journal_title：Biochemical and biophysical research communications

authors： Jayachandran M,Hayashi T,Sumi D,Thakur NK,Kano H,Ignarro LJ,Iguchi A

更新日期：2001-01-26 00:00:00

abstract：:Contraction of rat uterine smooth muscle related to phosphorylation state of myosin light chain under various conditions was investigated. In the Ca2(+)-containing medium, both high K+ and oxytocin induced marked contraction of the muscle accompanied by pronounced phosphorylation of myosin light chain. In the Ca2(+)-f...

journal_title：Biochemical and biophysical research communications

authors： Oishi K,Takano-Ohmuro H,Minakawa-Matsuo N,Suga O,Karibe H,Kohama K,Uchida MK

更新日期：1991-04-15 00:00:00

abstract：:Poly(ADP-ribose) polymerase (ADPRP) is a nuclear enzyme that transfers ADP-ribose from NAD+ to diverse nuclear proteins. Previously, the function of ADPRP was considered to relate exclusively to its catalytic activity. However, recent experiments have shown that ADPRP is actually an abundant DNA-binding protein, and t...

journal_title：Biochemical and biophysical research communications

authors： Nobori T,Yamanaka H,Carson DA

更新日期：1989-09-15 00:00:00

abstract：:A sulfotransferase activity present in the cytosol fraction of rat submandibular and parotid salivary glands catalyzes the transfer of sulfate group from 3'-phosphoadenosine-5'-phosphosulfate to C-6 of the terminal glucose residue of Glc alpha 1 leads to 6Glc alpha 1 leads to 6Glc alpha 1 leads to 3-1, (3)-0-alkyl-2-0...

journal_title：Biochemical and biophysical research communications

authors： Slomiany BL,Liau YH,Zdebska E,Murty VL,Slomiany A

更新日期：1983-06-29 00:00:00

abstract：:A heparan sulfate glycosaminoglycan chain, biotinylated at its reducing-end, was bound to a streptavidin-coated biochip. Surface plasmon resonance spectroscopy showed a low affinity interaction with antithrombin III (ATIII) when it was flowed over a surface containing heparan sulfate. ATIII bound tightly with high aff...

journal_title：Biochemical and biophysical research communications

authors： Hernaiz M,Liu J,Rosenberg RD,Linhardt RJ

更新日期：2000-09-16 00:00:00

abstract：:Vomeronasal organs of female Wistar rats were exposed with sprayed urine preparations of male Wistar rats prior to sacrifice. Exposure to crude urine and ultrafiltrated urine preparation (<5000 Da) induced significant Fos expression, which is correlated with cellular activity, in the mitral/tufted cell layer of the ac...

journal_title：Biochemical and biophysical research communications

authors： Tsujikawa K,Kashiwayanagi M

更新日期：1999-06-24 00:00:00

abstract：:Hypoxia is generally detected in central regions of solid tumors and regulates a variety of transcription factors including hypoxia-inducible factor-1 (HIF-1). HIF-1 plays a pivotal role in cellular response to low oxygen concentration, such as angiogenesis in tumor. Here, we found that a histone deacetylase (HDAC) in...

journal_title：Biochemical and biophysical research communications

authors： Mie Lee Y,Kim SH,Kim HS,Jin Son M,Nakajima H,Jeong Kwon H,Kim KW

更新日期：2003-01-03 00:00:00

abstract：:Neuroblastoma LAN-5 cells exposed to retinoic acid cease to multiply and extend neurite outgrowths acquiring a neuronal phenotype. We now report that protein kinase C-theta; (PKC-theta;) isozyme is involved in this differentiation process due to the following findings: (i) PKC-theta; is expressed by LAN-5 cells as a n...

journal_title：Biochemical and biophysical research communications

authors： Sparatore B,Patrone M,Passalacqua M,Pedrazzi M,Pontremoli S,Melloni E

更新日期：2000-12-20 00:00:00

abstract：:Growth and differentiation factors (GDF)-5, -6, and -7 are members of the bone morphogenetic protein (BMP) family. Previous studies suggest their importance in bone development and in tendon/ligament morphogenesis. The cells of the dental attachment apparatus, cementum, periodontal ligament, and alveolar bone proper a...

journal_title：Biochemical and biophysical research communications

authors： Morotome Y,Goseki-Sone M,Ishikawa I,Oida S

更新日期：1998-03-06 00:00:00

abstract：:DNA containing unmethylated cytosine-guanine motifs (CpG DNA) initiates innate immune responses, including the secretion of cytokines from macrophages. Some antimicrobial peptides modulate the responses to CpG DNA, although the molecular mechanisms of this process remain unclear. This study examined the effects of fou...

journal_title：Biochemical and biophysical research communications

authors： Nishihara S,Kawasaki K

更新日期：2020-09-10 00:00:00

abstract：:FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing ...

journal_title：Biochemical and biophysical research communications

authors： Ma C,Peng C,Lu X,Ding X,Zhang S,Zou X,Zhang X

更新日期：2015-03-06 00:00:00

abstract：:Although compelling data have demonstrated the effectiveness of estrogen replacement therapy for the treatment of accelerated bone loss in postmenopausal osteoporosis and ovariectomized animals, the mechanisms by which estrogens reduce bone resorption remain to be elucidated. To address this issue, in the present stud...

journal_title：Biochemical and biophysical research communications

authors： Zecchi-Orlandini S,Formigli L,Tani A,Benvenuti S,Fiorelli G,Papucci L,Capaccioli S,Orlandini GE,Brandi ML

更新日期：1999-02-24 00:00:00