Abstract:
:Vomeronasal organs of female Wistar rats were exposed with sprayed urine preparations of male Wistar rats prior to sacrifice. Exposure to crude urine and ultrafiltrated urine preparation (<5000 Da) induced significant Fos expression, which is correlated with cellular activity, in the mitral/tufted cell layer of the accessory olfactory bulb (AOB), while exposure to the remaining substances after ultrafiltration (>5000 Da) and control salt solution did not. Exposure to urine preparation treated with papain induced expression of Fos-immunoreactive cells in the rostral region of the AOB, but did not induce such expression in the caudal region. Exposure to urine preparation treated with pronase induced urine-specific Fos immunoreactivity neither in the rostral nor in the caudal region. These results suggest that at least two different peptides carrying pheromonal activities are contained in male Wistar rat urine.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Tsujikawa K,Kashiwayanagi Mdoi
10.1006/bbrc.1999.0873subject
Has Abstractpub_date
1999-06-24 00:00:00pages
222-4issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(99)90873-2journal_volume
260pub_type
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