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Mitochondria and microsomal membranes have a free radical reductase activity that prevents chromanoxyl radical accumulation.

Abstract：

:Enzyme-dependent mechanisms which prevent accumulation of chromanoxyl radicals derived from the vitamin E analogue, 2,2,5,7,8-pentamethyl-6-hydroxycromane (PMC), were characterized in rat liver microsomal and mitochondrial membranes. The free radical oxidation product of PMC (chromanoxyl radical) was generated in membranes using either photochemical (uv light) or enzymatic (lipoxygenase and arachidonic acid) methods and detected by ESR. Substrates (NADH or NADPH) prevented accumulation of chromanoxyl radicals until the substrate was fully consumed. In microsomes, reduced glutathione increased the efficacy of NADPH in preventing the accumulation of the chromanoxyl radical, but was without effect in the absence of NADPH. Ascorbate also prevented accumulation of the chromanoxyl radical. It is concluded that rat liver microsomes and mitochondria have both enzymatic and non-enzymatic mechanisms for reducing chromanoxyl radicals.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Packer L,Maguire JJ,Mehlhorn RJ,Serbinova E,Kagan VE

doi

10.1016/0006-291x(89)92427-3

subject

Has Abstract

pub_date

1989-02-28 00:00:00

pages

229-35

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92427-3

journal_volume

159

pub_type

杂志文章

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