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Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation.

Abstract：

:Using isolated rat hepatocytes we have shown that glutathione (GSH) depletion by glutathione-S-transferase (GST)-catalyzed conjugation with 1-bromoheptane or phorone was accompanied by a significant elevation in ascorbate synthesis. Glycogenolysis was also stimulated without a significant rise in glucose synthesis. Furthermore, when glycogenolysis was stimulated in control hepatocytes by increasing intracellular cAMP levels (with glucagon or dibutyryl cAMP), cellular glucose levels, but not ascorbate levels, increased. These data suggest that GSH depletion can stimulate ascorbate synthesis independently of glucose synthesis and that hepatocytes can direct glycogenolysis towards ascorbate synthesis during GSH conjugation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chan TS,Wilson JX,O'Brien PJ

doi

10.1016/j.bbrc.2004.03.022

subject

Has Abstract

pub_date

2004-04-23 00:00:00

pages

149-56

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X04004905

journal_volume

317

pub_type

杂志文章

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