Abstract:
:mRNA levels of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-2, were determined during chemical hepatocarcinogenesis and during regeneration of rat liver. In chemical hepatocarcinogenesis, the mRNA levels of MKP-1 were increased in primary hepatomas but decreased in rat ascites hepatomas as compared with normal liver. MKP-2 was undetectable in normal liver but strongly expressed in hepatomas. The MKP-2 mRNA level was increased with expression of malignant phenotypes in hepatomas. In regenerating liver, the mRNA level of MKP-1 increased immediately but transiently after partial hepatectomy, and peaked again on day 10, the time when hepatocytes cease proliferation. The elevated expression of MKP-1 on day 10 suggests some roles of MKP-1 as a negative regulator in hepatocyte proliferation.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Yokoyama A,Karasaki H,Urushibara N,Nomoto K,Imai Y,Nakamura K,Mizuno Y,Ogawa K,Kikuchi Kdoi
10.1006/bbrc.1997.7547subject
Has Abstractpub_date
1997-10-29 00:00:00pages
746-51issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(97)97547-1journal_volume
239pub_type
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