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GRF (somatocrinin) stimulates release of neurotensin, calcitonin and cAMP by a rat C cell line.

Abstract：

:We reported previously that GRF stimulates release of neurotensin (NT) by a clonal line of rat C cells (44-2 C). We report here that GRF stimulates calcitonin (CT) and cAMP release in these cells. For release experiments, replicate cultures are incubated for 5-180 min in serum-free defined medium. CT, NT and cAMP are measured by RIA. At a maximally effective concentration of GRF (.1-1.0 nM), there is a 2-3 fold stimulation of CT release at 60-90 min with peak release at 180 min. In contrast, GRF causes a rapid 4-6 fold increase of NT release within 5-15 min. In 44-2 C cells there is a 4-40 fold stimulation of cAMP release by GRF. We conclude that in 44-2 C cells GRF stimulates release of NT and cAMP and show for the first time the effect of this peptide on release of CT.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zeytin F,Brazeau P

doi

10.1016/0006-291x(84)90258-4

subject

Has Abstract

pub_date

1984-09-17 00:00:00

pages

497-506

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)90258-4

journal_volume

123

pub_type

杂志文章

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