Expression of galectin-9 by IFN-γ stimulated human nasal polyp fibroblasts through MAPK, PI3K, and JAK/STAT signaling pathways.

abstract：:Hand-foot skin reaction (HFSR) is a common side effect of multiple tyrosine kinase inhibitors (mTKIs). HFSR can necessitate dose reductions or interruption of therapy owing to its negative effect on the quality of life. Therefore, effective use of mTKIs requires measures to prevent HFSR. We evaluated the effect of pro...

journal_title：Biochemical and biophysical research communications

authors： Shichiri H,Yamamoto K,Tokura M,Ishida T,Uda A,Bito T,Nishigori C,Nakagawa T,Hirano T,Yano I,Hirai M

更新日期：2017-04-01 00:00:00

abstract：:Sorting motifs are involved in the transport of diverse proteins. In the present study, we identified a hydrophobic peptide (WRPWRNFWWSIRVPWRRN) that was able to target enhanced green fluorescent protein- or DsRed2-enriched vesicular-like sub-compartments of the endoplasmic reticulum (ER). Analysis of mutation constru...

journal_title：Biochemical and biophysical research communications

authors： Nie YW,Wang M,Zhang P,Huan L,Liu DJ

更新日期：2016-04-22 00:00:00

abstract：:We previously showed in a primary culture of rat testicular cells that spermatogenic cells specifically bind to somatic Sertoli cells and that this interaction is needed for spermatogenic cells to differentiate in vitro. Adopting an expression cloning procedure, we here isolated a cDNA coding for a spermatogenic cell ...

journal_title：Biochemical and biophysical research communications

authors： Maeda T,Sakashita M,Ohba Y,Nakanishi Y

更新日期：1998-07-09 00:00:00

abstract：:Loaded under whole cell patch-clamp configuration, the caged Ca2+ molecule DM-nitrophen was used to increase [Ca2+]i rapidly and reversibly in isolated Deiters cells of the organ of Corti. Photolysis of DM-nitrophen increased [Ca2+]i from resting concentrations of 20-50 nM to values above microM, as measured with the ...

journal_title：Biochemical and biophysical research communications

authors： Dulon D,Blanchet C,Laffon E

更新日期：1994-06-30 00:00:00

abstract：:RNA extracts from the isthmus of laying hen oviduct contain truncated 5S RNA molecules that were found to be shorter at their 5' terminus as compared to native 5S RNA I and II. Moreover one of the truncated species differs from 5S RNA I by the absence of the 3' end nucleotide. The truncated forms increase of about 70%...

journal_title：Biochemical and biophysical research communications

authors： Keith G,Nys Y,Fix C,Heyman T

更新日期：1986-08-14 00:00:00

abstract：:Matrin 3, a nuclear matrix protein has potential (1) to withhold promiscuously edited RNAs within the nucleus in cooperation with p54(nrb) and PSF, (2) to mediate NMDA-induced neuronal death, and (3) to modulate promoter activity of genes proximal to matrix/scaffold attachment region (MAR/SAR). We identified a biparti...

journal_title：Biochemical and biophysical research communications

authors： Hisada-Ishii S,Ebihara M,Kobayashi N,Kitagawa Y

更新日期：2007-03-02 00:00:00

abstract：:Macroautophagy (autophagy) is an intracellular catalytic process. We examined the effect of running exercise, which stimulates cardiac work physiologically, on the expression of microtubule-associated protein 1 light chain 3 (LC3)-II, an indicator of autophagy, as well as some autophagy-related proteins in rat cardiac...

journal_title：Biochemical and biophysical research communications

authors： Ogura Y,Iemitsu M,Naito H,Kakigi R,Kakehashi C,Maeda S,Akema T

更新日期：2011-11-04 00:00:00

abstract：:Circadian variations in the levels of prostaglandins (PGs) D2, E2, and F2 alpha were studied in the cerebrospinal fluid (CSF) of rats. We collected CSF samples from the cisterna magna of anesthetized rats at different clock-hours (1000, 1400, 1800, 2200, 0200, and 0600 hr), and measured the concentrations of the three...

journal_title：Biochemical and biophysical research communications

authors： Pandey HP,Ram A,Matsumura H,Satoh S,Hayaishi O

更新日期：1995-08-15 00:00:00

abstract：:Gastric inhibitory polypeptide (GIP) is released from the small intestine upon meal ingestion and increases insulin secretion from pancreatic β cells. Although the GIP receptor is known to be expressed in small intestine, the effects of GIP in small intestine are not fully understood. This study was designed to clarif...

journal_title：Biochemical and biophysical research communications

authors： Ogawa E,Hosokawa M,Harada N,Yamane S,Hamasaki A,Toyoda K,Fujimoto S,Fujita Y,Fukuda K,Tsukiyama K,Yamada Y,Seino Y,Inagaki N

更新日期：2011-01-07 00:00:00

abstract：:The frequency of p73 mutation is low in hematologic malignancies as well as solid tumors. Aberrant DNA methylation of multiple promoter associated CpG islands is a frequent phenomenon in acute lymphoblastic leukemia (ALL). In the present study, we scanned for mutations in the exons 4, 5, 6, and 7 of p73 gene. Using PC...

journal_title：Biochemical and biophysical research communications

authors： Sahu GR,Das BR

更新日期：2005-02-18 00:00:00

abstract：:The ribonucleotide reductase from the strictly anaerobic methanogen Methanobacterium thermoautotrophicum has been partially purified by ion-exchange and gel-filtration chromatography. Its molecular weight is estimated to be 100,000 by the latter step. Unlike all previously studied ribonucleotide reductases, the enzyme...

journal_title：Biochemical and biophysical research communications

authors： Sze IS,McFarlan SC,Spormann A,Hogenkamp HP,Follmann H

更新日期：1992-04-30 00:00:00

abstract：:One hypothesis for the etiology of Parkinson's disease (PD) is that the formation of proteinaceous inclusion, which is mainly composed of alpha-synuclein, may contribute to the selective loss of dopaminergic neurons. To further explore the role of alpha-synuclein in neurodegeneration of PD, we examined the possible ef...

journal_title：Biochemical and biophysical research communications

authors： Yu F,Xu H,Zhuo M,Sun L,Dong A,Liu X

更新日期：2005-05-27 00:00:00

abstract：:p21(Waf1/Cip1) is one of the key regulatory proteins in cell cycle, terminal differentiation, and apoptosis. Its promoter was shown to be transactivated by the wild-type p53 protein as well as in a p53-independent manner. In this report, we demonstrate that E1AF, an ets-related transcription factor, activates the huma...

journal_title：Biochemical and biophysical research communications

authors： Funaoka K,Shindoh M,Yoshida K,Hanzawa M,Hida K,Nishikata S,Totsuka Y,Fujinaga K

更新日期：1997-07-09 00:00:00

abstract：:Hepatocyte growth factor (HGF) specifically activates Met tyrosine kinase receptor, leading to mitogenic, motogenic, and morphogenic responses in a wide variety of cells. To know a role of HGF in Xenopus embryogenesis, loss-of-function mutation was introduced by dominant expression of truncated tyrosine kinase-negativ...

journal_title：Biochemical and biophysical research communications

authors： Aoki S,Takahashi K,Matsumoto K,Nakamura T

更新日期：1997-05-08 00:00:00

abstract：:Metastatic hepatocellular carcinoma (HCC) remains a mostly incurable disease. The fact that the identity of the mechanisms that regulate metastasis in HCC is known hampers the development of anti-metastatic therapies. Currently, there is no effective treatment for HCC once it is progressed to metastatic stage. Therefo...

journal_title：Biochemical and biophysical research communications

authors： Wu Y,Liu ZG,Shi MQ,Yu HZ,Jiang XY,Yang AH,Fu XS,Xu Y,Yang S,Ni H,Shen SJ,Li WD

更新日期：2017-09-16 00:00:00

abstract：:Fut8 (α1,6-Fucosyltransferase) heterozygous knock-out (Fut8(+/-)) mice had an increased influx of inflammatory cells into the lungs, and this was associated with an up-regulation of matrix metalloproteinases, MMP-2 and MMP-9, after treatment with porcine pancreatic elastase (PPE), exhibiting an emphysema-prone phenoty...

journal_title：Biochemical and biophysical research communications

authors： Kamio K,Yoshida T,Gao C,Ishii T,Ota F,Motegi T,Kobayashi S,Fujinawa R,Ohtsubo K,Kitazume S,Angata T,Azuma A,Gemma A,Nishimura M,Betsuyaku T,Kida K,Taniguchi N

更新日期：2012-07-20 00:00:00

abstract：:Alzheimer's disease (AD) pathology is characterized by plaques, tangles, and neuronal cell loss. The main constituent of plaques is beta-amyloid peptide (A beta), a 39-42 residue peptide which has been linked to disruption of calcium homeostasis and neurotoxicity in vitro. We demonstrate that a neurotoxic fragment of ...

journal_title：Biochemical and biophysical research communications

authors： Mirzabekov T,Lin MC,Yuan WL,Marshall PJ,Carman M,Tomaselli K,Lieberburg I,Kagan BL

更新日期：1994-07-29 00:00:00

abstract：:The effect of phosphorylation by cyclic AMP dependent protein kinase on the assembly of the core-forming 68 KDa neurofilament subunit protein (NF-L) was studied in vitro by fluorescence energy transfer and electron microscopy. Phosphorylation of unassembled NF-L in a low ionic strength buffer by cyclic AMP dependent p...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Takeda M,Angelides KJ,Tanaka T,Tada K,Nishimura T

更新日期：1990-06-15 00:00:00

abstract：:Enterolactone, a lignan that has been identified in biological samples from man and several mammals, shares with ascorbic acid and cardiac glycosides a gamma-butyrolactone. It displaces 3H-ouabain from its binding sites on cardiac digitalis receptor and inhibits, dose dependently, the Na+, K+-ATPase activity of human ...

journal_title：Biochemical and biophysical research communications

authors： Fagoo M,Braquet P,Robin JP,Esanu A,Godfraind T

更新日期：1986-02-13 00:00:00

abstract：:A cDNA encoding the entire tau subunit of rabbit skeletal muscle phosphorylase kinase was reconstructed and inserted into a plasmid containing the Escherichia coli ptac promoter and a constructed plasmid containing the ptac promoter and bacterial chloramphenicol acetyl transferase (CAT) gene, respectively. A significa...

journal_title：Biochemical and biophysical research communications

authors： Chen LR,Yuan CJ,Somasekhar G,Wejksnora P,Peterson JE,Myers AM,Graves L,Cohen PT,da Cruz e Silva EF,Graves DJ

更新日期：1989-06-15 00:00:00

abstract：:Nuclear envelope peptides of the rat ventral prostate in the molecular weight region 18,400 to 19,400 show marked androgen dependence. After castration these peptides disappear. Re-administration of testosterone restores them. They were not extracted by 0.1 M NaCl or 5% HClO4 but were partially extracted by 0.35 M NaC...

journal_title：Biochemical and biophysical research communications

authors： Venkatraman JT,Howell GM,Lefebvre YA

更新日期：1984-12-14 00:00:00

abstract：:Recent studies have established that polypeptide growth factors cause an elevation of the cytoplasmic pH (pHi) in cultured mammalian cells by stimulating Na+/H+ exchange. We show that vanadate, previously found to act as a mitogen for a number of cells, reversibly activates Na+/H+ exchange at micromolar concentrations...

journal_title：Biochemical and biophysical research communications

authors： Cassel D,Zhuang YX,Glaser L

更新日期：1984-01-30 00:00:00

abstract：:Augmenter of liver regeneration (ALR) is known to support liver regeneration and to stimulate proliferation of hepatocytes. However, it is not known if ALR exerts anti-apoptotic effects in human hepatocytes and whether this protective effect is cell type specific. This is relevant, because compounds that protect the l...

journal_title：Biochemical and biophysical research communications

authors： Ilowski M,Kleespies A,de Toni EN,Donabauer B,Jauch KW,Hengstler JG,Thasler WE

更新日期：2011-01-07 00:00:00

abstract：:Antisense activity in living cells has been thought to occur via a mechanism involving both DNA-mediated hybridization arrest of target mRNA and RNase H-mediated mRNA digestion. Therefore an ideal antisense agent should be permeable to the cell and possess capacities (1) to form a thermally stable duplex in vivo with ...

journal_title：Biochemical and biophysical research communications

authors： Matsukura M,Okamoto T,Miike T,Sawai H,Shinozuka K

更新日期：2002-05-24 00:00:00

abstract：:The calmodulin-like domain of calpain is important for the association of the calpain large and small subunits. We expressed the calmodulin-like domains of the large subunits of rabbit mu- and m-calpains and their small subunits in E. coli and purified them to homogeneity. Unlike the full-length subunits, the calmodul...

journal_title：Biochemical and biophysical research communications

authors： Suo S,Koike H,Sorimachi H,Ishiura S,Suzuki K

更新日期：1999-04-02 00:00:00

abstract：:Long-term glucocorticoid (GC) usage may cause non-traumatic femoral head osteonecrosis. Dexamethasone (Dex) is shown to exert potent cytotoxic effect to osteoblasts. Here, we investigated the potential activity of α-melanocyte stimulating hormone (α-MSH) against the process. Our data revealed that pretreatment of α-MS...

journal_title：Biochemical and biophysical research communications

authors： Guo S,Xie Y,Fan JB,Ji F,Wang S,Fei H

更新日期：2016-01-08 00:00:00

abstract：:A rat liver-specific antigen (RLSA) lost its binding ability to the corresponding monoclonal antibody after treatment with N-glycanase or sialidase, which suggested that the specific binding site might be in a portion of the sugar chain containing sialic acid. The specific antigen reacted with wheat germ agglutinin, l...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Ikeda T,Osada Y

更新日期：1988-05-16 00:00:00

abstract：:The Forkhead/Fox transcription factor Foxc2 is a critical regulator of vascular development. However, the role of Foxc2 in pathological angiogenesis in cancer remains unknown. Here we show that FoxC2 is highly expressed in human breast and colonic tumors and in the tumor endothelium in human and mouse melanomas. Using...

journal_title：Biochemical and biophysical research communications

authors： Sano H,Leboeuf JP,Novitskiy SV,Seo S,Zaja-Milatovic S,Dikov MM,Kume T

更新日期：2010-02-05 00:00:00

abstract：:Heparin binding neurite-promoting factor (HBNF) is a highly basic 136 amino acid protein containing 10 cysteine residues. We have determined the redox status and the disulfide arrangement of the cysteine residues in HBNF from bovine brain and refolded human recombinant protein produced in E. coli. Our data indicate th...

journal_title：Biochemical and biophysical research communications

authors： Hulmes JD,Seddon AP,Decker MM,Böhlen P

更新日期：1993-04-30 00:00:00

abstract：:CCG-1423, a chemical inhibitor of Rho signaling, blocks serum response factor (SRF)/megakaryoblastic leukemia 1 (MKL1)-mediated gene expression by inhibiting the nuclear accumulation of MKL1. Several studies have suggested that CCG-1423 interacts not only with MKL1, which has a critical role in the regulation of neuro...

journal_title：Biochemical and biophysical research communications

authors： Kikuchi K,Shiota J,Yamada T,Ishikawa M,Ihara D,Fukuchi M,Tsuda M,Tabuchi A

更新日期：2017-10-21 00:00:00