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Bipartite nuclear localization signal of matrin 3 is essential for vertebrate cells.

Abstract：

:Matrin 3, a nuclear matrix protein has potential (1) to withhold promiscuously edited RNAs within the nucleus in cooperation with p54(nrb) and PSF, (2) to mediate NMDA-induced neuronal death, and (3) to modulate promoter activity of genes proximal to matrix/scaffold attachment region (MAR/SAR). We identified a bipartite nuclear localization signal (NLS) of chicken matrin 3 (cmatr3) at residues 583-602. By expressing green fluorescent protein (GFP) fused to the NLS mutant in chicken DT40 cells, we showed an essential role of the NLS for cell proliferation. Furthermore, we showed that both clusters of basic amino acids and a linker of the bipartite NLS were essential and sufficient for the nuclear import of GFP. Exogenous cmatr3 rescued the HeLa cells where human matrin 3 was suppressed by RNA interference, but cmatr3 containing deletions at either of the basic amino acid clusters or the linker could not.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hisada-Ishii S,Ebihara M,Kobayashi N,Kitagawa Y

doi

10.1016/j.bbrc.2006.12.191

subject

Has Abstract

pub_date

2007-03-02 00:00:00

pages

72-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02807-5

journal_volume

354

pub_type

杂志文章

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