Detection of a novel variant human hemoglobin by electrospray ionization mass spectrometry.

abstract：:We investigated the effects of oxidative stress on mRNA levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and amphiregulin (AR) in rat gastric epithelial RGM1 cells. In response to stimulation with hydrogen peroxide (100-400 microM), gene expression of HB-EGF and AR increased in a dose-depe...

journal_title：Biochemical and biophysical research communications

authors： Miyazaki Y,Shinomura Y,Tsutsui S,Yasunaga Y,Zushi S,Higashiyama S,Taniguchi N,Matsuzawa Y

更新日期：1996-09-13 00:00:00

abstract：:Members of the Ca2+/calmodulin dependent protein kinase (CaMK) family and a CaMK cascade have been identified and well characterized in the brain, but little is known about their equivalents in the heart. Thus only CaMKII and its function have been reported so far. Therefore, we purified and characterized CaMKI and Ca...

journal_title：Biochemical and biophysical research communications

authors： Uemura A,Naito Y,Matsubara T,Hotta N,Hidaka H

更新日期：1998-08-19 00:00:00

abstract：:Due to their spontaneous accumulation in inflamed or infected areas, blood phagocytes are potent drug vectors with specific targeting. Drug like molecule loading was obtained by use of cell electropermeabilization in which the impermeability of their plasma membrane is transiently impaired. Electrical conditions were ...

journal_title：Biochemical and biophysical research communications

authors： Sixou S,Teissié J

更新日期：1992-07-31 00:00:00

abstract：:Expression of the MHC class I chain related molecules A and B (MICA/B) on tumor cell surface can signal the immune receptor NKG2D for tumor immune destruction. However, MIC was found to be shed by tumors in cancer patients, which negatively regulates host immunity and promotes tumor immune evasion and progression. The...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Lundgren AD,Singh P,Goodlett DR,Plymate SR,Wu JD

更新日期：2009-09-25 00:00:00

abstract：:Diabetic cardiomyopathy represents severe heart complications, and is the leading cause of morbidity and mortality among patients with diabetes. Although a few microRNAs (miRNAs) have been implicated in diabetes-related complications, a functional association between miRNAs and cardiac dysfunction in diabetic cardiomy...

journal_title：Biochemical and biophysical research communications

authors： Qiao Y,Zhao Y,Liu Y,Ma N,Wang C,Zou J,Liu Z,Zhou Z,Han D,He J,Sun Q,Liu Y,Xu C,Du Z,Huang H

更新日期：2016-09-02 00:00:00

abstract：:The technology of real-time imaging in living cells is crucial for understanding of intracellular events. For this purpose, bioluminescent reporters have been introduced as sensitive and convenient tools. Metridia luciferase (MLuc) from the copepod Metridia longa is a coelenterazine-dependent luciferase containing a n...

journal_title：Biochemical and biophysical research communications

authors： Markova SV,Burakova LP,Vysotski ES

更新日期：2012-01-06 00:00:00

abstract：AIM:AF1q has a precise oncogenic function. The purpose of this study is to investigate whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt's lymphoma (BL), and thus has potential to enhance immunotherapy and reduce side effects. METHODS:We established BL cell lines with altered AF1q expression usin...

journal_title：Biochemical and biophysical research communications

authors： Togano T,Kim N,Kim N,Park GS,Park AK,Bennet M,Park J

更新日期：2019-11-26 00:00:00

abstract：:Multiple system atrophy is a neurodegenerative disease caused by abnormal α-synuclein (α-syn) accumulation in oligodendrocytes and neurons. We previously demonstrated that transgenic (Tg) mice that selectively overexpressed human α-syn in oligodendrocytes exhibited neuronal α-syn accumulation. Microtubule β-III tubuli...

journal_title：Biochemical and biophysical research communications

authors： Ito H,Nakayama K,Jin C,Suzuki Y,Yazawa I

更新日期：2012-11-23 00:00:00

abstract：:O-GlcNAcylation is a kind of post-translational modification and many nuclear and cytoplasmic proteins are O-GlcNAcylated. In this study, we demonstrated that thiazolidinediones (TZDs), which are used as insulin sensitizer, specifically inhibited the O-GlcNAcylation of Sp1 but did not affect the O-GlcNAcylation of the...

journal_title：Biochemical and biophysical research communications

authors： Chung SS,Kim JH,Park HS,Choi HH,Lee KW,Cho YM,Lee HK,Park KS

更新日期：2008-08-08 00:00:00

abstract：:A PCR-based Sma I restriction fragment length polymorphism (RFLP) in the human D4 dopamine receptor (DRD4) gene was investigated in 200 subjects each of Japanese and Mongolian populations. When compared to allele frequencies for Caucasians previously reported by Petronis et al., Japanese and Mongolian populations show...

journal_title：Biochemical and biophysical research communications

authors： Nakatome M,Honda K,Tun Z,Wakasugi C

更新日期：1996-03-27 00:00:00

abstract：:In contrast to its stimulation of insulin binding to human placental membranes, calcium inhibited the binding of insulin-like growth factor-I. The effects on receptors for both peptides were half-maximal at 2 mM calcium, and were entirely due to alterations in high affinity binding sites for the respective ligands. Ca...

journal_title：Biochemical and biophysical research communications

authors： Baxter RC,Williams PF

更新日期：1983-10-14 00:00:00

abstract：:S-adenosyl-L-methionine (SAM)-dependent methyltransferases (MTases) methylate diverse biological molecules using a SAM cofactor. The ytqB gene of Bacillus subtilis encodes a putative MTase and its biological function has never been characterized. To reveal the structural features and the cofactor binding mode of YtqB,...

journal_title：Biochemical and biophysical research communications

authors： Park SC,Song WS,Yoon SI

更新日期：2014-04-18 00:00:00

abstract：:Human polymorphonuclear leukocytes in the presence of the Ca2+ ionophore A23187 plus Ca2+ incorporated exogenously-added [3H]acetate or 1-0-[3H]-alkyl-sn-glycero-3-phosphocholine (lysoplatelet-activating factor) into platelet-activating factor (PAF,1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine). The incorporation of ...

journal_title：Biochemical and biophysical research communications

authors： Billah MM,Siegel MI

更新日期：1984-01-30 00:00:00

abstract：:To investigate the role of secondary structure in the substrate specificity of human 72 kDa type IV collagenase, we synthesised linear and cyclic collagen sequence analogs. As Ca2+ plays a crucial role in the enzyme activity, the CD and FTIR spectra of the peptides were also measured in the presence of Ca2+. Most of t...

journal_title：Biochemical and biophysical research communications

authors： Likó Z,Botyánszki J,Bódi J,Vass E,Majer Z,Hollósi M,Süli-Vargha H

更新日期：1996-10-14 00:00:00

abstract：:Ceruloplasmin (Cp) is a copper-containing ferroxidase with potent antioxidant activity. Cp is expressed by hepatocytes and activated macrophages and has been known as physiologic inhibitor of myeloperoxidase (MPO). Enzymatic activity of MPO produces anti-microbial agents and strong prooxidants such as hypochlorous aci...

journal_title：Biochemical and biophysical research communications

authors： Bakhautdin B,Goksoy Bakhautdin E,Fox PL

更新日期：2014-10-31 00:00:00

abstract：:We previously showed that cor15, a cold-regulated gene from Arabidopsis thaliana, encodes a 15 kDa polypeptide designated COR15. Here we report that COR15 has potent cryoprotective activity in an in vitro cryoprotection assay. Specifically, COR15 was very effective in protecting the cold-labile enzyme lactate dehydrog...

journal_title：Biochemical and biophysical research communications

authors： Lin C,Thomashow MF

更新日期：1992-03-31 00:00:00

abstract：:Embryo development proceeds under strict temporal control and an embryonic molecular clock (EC), evidenced by cyclic gene expression, is operating during somite formation and limb development, providing temporal information to precursor cells. In somite precursor cells, EC gene expression and periodicity depends on Re...

journal_title：Biochemical and biophysical research communications

authors： Sheeba CJ,Palmeirim I,Andrade RP

更新日期：2012-07-13 00:00:00

abstract：:Cox-2 plays an important role in colon carcinogenesis and inflammation. Studying the HT-29 colon cancer cell line as a model, we found that Cox-2 expression and activity is increased approximately 25-fold by TNF-alpha. As previously reported for other Cox-2 inducers, this activation appears to result from a p38-mediat...

journal_title：Biochemical and biophysical research communications

authors： Tong X,Yin L,Giardina C

更新日期：2004-04-30 00:00:00

abstract：:Opioid binding properties of Tyr-D-Ser-Gly-Phe-Leu-Thr-NH-NH-Gly-Mal (DSLET-Mal), a novel enkephalin-framed affinity label, was determined in rat brain membranes. In competition studies the ligand showed high affinity for the delta opioid sites, labelled by [(3)H][Ile(5,6)]deltorphin II (K(i) = 8 nM), whereas its bind...

journal_title：Biochemical and biophysical research communications

authors： Szatmári I,Orosz G,Medzihradszky K,Borsodi A

更新日期：1999-11-19 00:00:00

abstract：:The dodecapeptide MCLV3 is a functional peptide, derived from the CLV3 precursor protein, which is a candidate ligand of the CLV1/CLV2 receptor complex that restricts the stem cell population in the shoot apical meristem (SAM). MCLV3 can induce shoot and root meristem consumption, the typical phenotype of transgenic p...

journal_title：Biochemical and biophysical research communications

authors： Kondo T,Nakamura T,Yokomine K,Sakagami Y

更新日期：2008-12-05 00:00:00

abstract：:Saccharomyces cerevisiae uso1-1 mutant stops the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus at 37 degrees C. We found that this temperature-sensitive defect was suppressed either by increasing the concentration of calcium ion in the medium or by introducing in the cell the SL...

journal_title：Biochemical and biophysical research communications

authors： Kito M,Seog DH,Igarashi K,Kambe-Honjo H,Yoda K,Yamasaki M

更新日期：1996-03-27 00:00:00

abstract：:An attempt was made to activate the capillary-bound fraction of lipoprotein lipase (LPL) with cAMP-dependent protein kinase catalytic subunit (PKC). Following a 30s washout period, hearts were perfused for 1 min with buffer containing heparin. Medium was collected during the second 30s of heparin perfusion. Addition o...

journal_title：Biochemical and biophysical research communications

authors： Oscai LB,Caruso RA,Palmer WK

更新日期：1986-02-26 00:00:00

abstract：:The conversion of the endogenous cellular prion protein to an abnormally folded isoform is a hallmark of transmissible spongiform encephalopathies. It occurs when a misfolded prion protein contacts the cellular PrP. Among the molecular partners suggested to be involved in the misfolding process, the glycosaminoglycans...

journal_title：Biochemical and biophysical research communications

authors： Martin R,Chantepie S,Chapuis J,Le-Duc A,Maftah A,Papy-Garcia D,Laude H,Petit JM,Gallet PF

更新日期：2011-10-28 00:00:00

abstract：:Ecdysone 20-monooxygenase activity and the factors which may regulate this steroid hydroxylase were examined in the midgut of the tobacco hornworm, Manduca sexta, during the last larval stadium. Radioassay experiments revealed that midgut ecdysone 20-monooxygenase undergoes a single 50-fold increase in activity tempor...

journal_title：Biochemical and biophysical research communications

authors： Keogh DP,Johnson RF,Smith SL

更新日期：1989-11-30 00:00:00

abstract：:Salmon calcitonin potently competes for amylin binding sites in rat brain and has amylin-like actions upon glucose metabolism in rat muscle. We report here that [125I]-salmon calcitonin binds to rat hindlimb muscle membranes with high affinity (Kd = 0.47 pM). Binding was inhibited by rat amylin (Ki = 2 nM), rat alpha ...

journal_title：Biochemical and biophysical research communications

authors： Kenney MA,Moore CX,Pittner R,Beaumont K

更新日期：1993-11-30 00:00:00

abstract：:Oxidative damage to DNA has been reported to occur in a wide variety of disease states. The most widely used "marker" for oxidative DNA damage is 8-hydroxyguanine. However, the use of only one marker has limitations. Exposure of calf thymus DNA to an .OH-generating system (CuCl(2), ascorbate, H(2)O(2)) or to hypochlor...

journal_title：Biochemical and biophysical research communications

authors： Whiteman M,Hong HS,Jenner A,Halliwell B

更新日期：2002-08-30 00:00:00

abstract：:Lactobacillus, a representative useful bacterium, in the intestinal tract was found to bind to some specific glycosphingolipids, like the pathogenic intestinal bacteria. Thin layer chromatography overlay assays using rabbit antiserum against Lactobacillus casei revealed that the bacteria bound to GA1 and trihexosylcer...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto K,Miwa T,Taniguchi H,Nagano T,Shimamura K,Tanaka T,Kumagai H

更新日期：1996-11-01 00:00:00

abstract：:The chemokine receptor CCR5 is constitutively associated with the T cell co-receptor CD4 in plasma cell membranes. The CD4-CCR5 complex exhibits distinct binding properties for macrophage inflammatory protein 1beta (MIP-1beta) and enhanced G-protein signaling as compared with those of CCR5 alone. Here we report that r...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Staudinger R

更新日期：2003-08-08 00:00:00

abstract：:The aggregation of beta-amyloid peptides is very important for their neurotoxic effect; standardization of the aggregation grade is necessary for biological experiments. Measurement of aggregation with physicochemical methods is a difficult task. The present work revealed that FT-IR can be used for studying the aggreg...

journal_title：Biochemical and biophysical research communications

authors： Szabó Z,Klement E,Jost K,Zarándi M,Soós K,Penke B

更新日期：1999-11-19 00:00:00

abstract：:The splicing factor SPF45 (RBM17) is a well-known component of the spliceosome that is involved in alternative splicing. RBM17 is frequently overexpressed in many tumors and plays a crucial role in cancer progression and drug resistance. However, the role of RBM17 in the development of glioma has not been thoroughly e...

journal_title：Biochemical and biophysical research communications

authors： Lu J,Li Q,Cai L,Zhu Z,Guan J,Wang C,Xia J,Xia L,Wen M,Zheng W,Su Z,Wang C

更新日期：2018-10-20 00:00:00