Abstract:
:Diabetic cardiomyopathy represents severe heart complications, and is the leading cause of morbidity and mortality among patients with diabetes. Although a few microRNAs (miRNAs) have been implicated in diabetes-related complications, a functional association between miRNAs and cardiac dysfunction in diabetic cardiomyopathy remains to be demonstrated. Our results show that miR-483-3p is upregulated in streptozotocin-induced diabetic mice, and cultured cardiomyocytes mimicking hyperglycemia. Overexpressing miR-483-3p in transgenic mice with diabetes mellitus (DM) exacerbated cardiomyocyte apoptosis by transcriptionally repressing insulin growth factor 1 (IGF1). Therefore, we have uncovered a novel signaling pathway, involving miR-483-3p-IGF1, that promotes myocardial cell apoptosis under high blood-glucose condition. Further, our study indicates that miR-483-3p could be a potential therapeutic target for managing diabetes-associated heart complications.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Qiao Y,Zhao Y,Liu Y,Ma N,Wang C,Zou J,Liu Z,Zhou Z,Han D,He J,Sun Q,Liu Y,Xu C,Du Z,Huang Hdoi
10.1016/j.bbrc.2016.06.051subject
Has Abstractpub_date
2016-09-02 00:00:00pages
541-547issue
4eissn
0006-291Xissn
1090-2104pii
S0006-291X(16)30969-Xjournal_volume
477pub_type
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