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miR-483-3p regulates hyperglycaemia-induced cardiomyocyte apoptosis in transgenic mice.

Abstract：

:Diabetic cardiomyopathy represents severe heart complications, and is the leading cause of morbidity and mortality among patients with diabetes. Although a few microRNAs (miRNAs) have been implicated in diabetes-related complications, a functional association between miRNAs and cardiac dysfunction in diabetic cardiomyopathy remains to be demonstrated. Our results show that miR-483-3p is upregulated in streptozotocin-induced diabetic mice, and cultured cardiomyocytes mimicking hyperglycemia. Overexpressing miR-483-3p in transgenic mice with diabetes mellitus (DM) exacerbated cardiomyocyte apoptosis by transcriptionally repressing insulin growth factor 1 (IGF1). Therefore, we have uncovered a novel signaling pathway, involving miR-483-3p-IGF1, that promotes myocardial cell apoptosis under high blood-glucose condition. Further, our study indicates that miR-483-3p could be a potential therapeutic target for managing diabetes-associated heart complications.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Qiao Y,Zhao Y,Liu Y,Ma N,Wang C,Zou J,Liu Z,Zhou Z,Han D,He J,Sun Q,Liu Y,Xu C,Du Z,Huang H

doi

10.1016/j.bbrc.2016.06.051

subject

Has Abstract

pub_date

2016-09-02 00:00:00

pages

541-547

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)30969-X

journal_volume

477

pub_type

杂志文章

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