The isoforms of α-actin and myosin affect the Ca2+ regulation of the actin-myosin interaction in the heart.

abstract：:We examined the possibility that bilirubin physiologically acts as an antioxidant by using scurvy-prone ODS-od/od rats treated with endotoxin (lipopolysaccharide: LPS). Recently, bilirubin oxidative metabolites were isolated from human urine and named biotripyrrin-a and biotripyrrin-b. The LPS injection markedly incre...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Horio F,Hashizume T,Tanaka M,Ikeda S,Kakinuma A,Nakajima H

更新日期：1995-09-05 00:00:00

abstract：:The effect of endothelin-1 (ET-1) on secretion and synthesis of rat atrial natriuretic peptide (rANP) as well as its mRNA levels was studied in primary cultures of neonatal rat atrial cardiocytes. ET-1 dose-dependently (10(-10)-10(-7) M) increased media and cellular rANP-like immunoreactivity as well as its cytoplasmi...

journal_title：Biochemical and biophysical research communications

authors： Fukuda Y,Hirata Y,Taketani S,Kojima T,Oikawa S,Nakazato H,Kobayashi Y

更新日期：1989-11-15 00:00:00

abstract：:Elevated Na(+) concentration ([Na(+)]) in the cerebrospinal fluid (CSF) contributes to the development of salt-sensitive hypertension. CSF is formed by the choroid plexus (CP) in cerebral ventricles, and [Na(+)] in CSF is controlled by transporters in CP. Here, we examined the effect of high salt diet on the expressio...

journal_title：Biochemical and biophysical research communications

authors： Guo L,Meng J,Xuan C,Ge J,Sun W,O'Rourke ST,Sun C

更新日期：2015-05-29 00:00:00

abstract：:Etoposide-induced 2.4 kb transcript (EI24, also known as PIG8) is a p53 target gene involved in cell growth suppression and apoptosis and known to be frequently altered in human cancers. Although EI24 expression is decreased in various cancers and is associated with colorectal cancer progression and metastasis, the ph...

journal_title：Biochemical and biophysical research communications

authors： Nam TW,Park SY,Lee JH,Roh JI,Lee HW

更新日期：2019-07-05 00:00:00

abstract：:The age-related reduction in the function of osteoblasts plays a central role in the pathogenesis of bone loss and osteoporosis. Collagen synthesis is a primary function of differentiated osteoblasts, however, the mechanisms for age-related changes in collagen synthesis in human osteoblasts remain elusive. We use Gene...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,Zhao G,Zhang Y,Wang J,Wang Y,Cheng L,Sun M,Rui Y

更新日期：2018-10-12 00:00:00

abstract：:It is recognized that genetic factors play a role in the susceptibility to COPD. COPD is characterized by airflow limitation. Chronic inflammation causes small airway disease and parenchymal destruction, leading to the airflow limitation. Polymorphisms in pro-inflammatory cytokine genes may confer a risk for the devel...

journal_title：Biochemical and biophysical research communications

authors： Hegab AE,Sakamoto T,Saitoh W,Nomura A,Ishii Y,Morishima Y,Iizuka T,Kiwamoto T,Matsuno Y,Massoud HH,Massoud HM,Hassanein KM,Sekizawa K

更新日期：2005-04-22 00:00:00

abstract：:2'-Deoxycoformycin (dCF), a specific and potent inhibitor of adenosine deaminase, has demonstrated significant antitumor effect on lymphoid malignancies. The drug induced functional and morphologic differentiation of myeloid leukemia cells in combination with 2'-deoxyadenosine (dAd), but not dCF alone. NB4, a cell lin...

journal_title：Biochemical and biophysical research communications

authors： Niitsu N,Umeda M,Honma Y

更新日期：1997-09-08 00:00:00

abstract：:The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential di...

journal_title：Biochemical and biophysical research communications

authors： Sung YJ,Conti J,Currie JR,Brown WT,Denman RB

更新日期：2000-09-07 00:00:00

abstract：:The present study demonstrates that exposure of human thyroid slices to thyrotropin causes an increase in phospholipid metabolism as measured by an increased incorporation of myo-2-[3H]-inositol into phosphatidylinositol, the generation of InsP3 and formation of GInsP as well as metabolism of phosphatidylcholine and p...

journal_title：Biochemical and biophysical research communications

authors： Mosko P,Zarzycki W,Jaroszewicz L,Kinalska I

更新日期：1994-06-30 00:00:00

abstract：:In Saccharomyces cerevisiae, transcription of ARO9 and ARO10 genes, involved in the catabolism of aromatic amino acids, is activated by Aro80 transcription factor in response to aromatic amino acids. Here we show that the transcription of ARO9 and ARO10 is also induced by heat shock in an Aro80-dependent manner. Howev...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Sung C,Kim BG,Hahn JS

更新日期：2013-08-16 00:00:00

abstract：:One of the mechanisms underlying the induction of human inducible nitric oxide synthase (hiNOS) by cytokines is transcriptional regulation. However, previous reports suggest that in human cells, the cytokine activation of the hiNOS expression is accompanied by a drastic increase in cellular mRNA and protein content, b...

journal_title：Biochemical and biophysical research communications

authors： Nunokawa Y,Oikawa S,Tanaka S

更新日期：1997-04-17 00:00:00

abstract：:The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme r...

journal_title：Biochemical and biophysical research communications

authors： Salzer W,Gerard C,McCall C

更新日期：1987-10-29 00:00:00

abstract：:In the present studies, cAMP, a secondary messenger historically viewed as a negative mediator of immune responses, was demonstrated to possess immunoenhancing activity at low concentrations. In parallel experiments the adenylate cyclase inhibitor, 2',3'-dideoxyadenosine, produced a marked inhibition of humoral and pr...

journal_title：Biochemical and biophysical research communications

authors： Koh WS,Yang KH,Kaminski NE

更新日期：1995-01-17 00:00:00

abstract：:CD36 expressed on adipocytes is thought to function as a fatty acid transporter (FAT). Here we report that adipocytes can endocytose and lysosomally degrade OxLDL, mainly mediated by CD36. Mouse 3T3-L1 preadipocytes showed marked increase in uptake and degradation of (125)I-OxLDL during their differentiation to adipoc...

journal_title：Biochemical and biophysical research communications

authors： Kuniyasu A,Hayashi S,Nakayama H

更新日期：2002-07-12 00:00:00

abstract：:Cluster 2b streptokinase (SK2b), secreted by invasive skin-trophic strains of Streptococcus pyogenes (GAS), is a human plasminogen (hPg) activator that optimally functions when human plasma hPg is bound, via its kringle-2 domain, to cognizant bacterial cells through the a1a2 domain of the major cellular hPg receptor, ...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Mayfield JA,Ploplis VA,Castellino FJ

更新日期：2014-02-21 00:00:00

abstract：:The extracellular matrix regulates many fundamental cellular processes such as proliferation, migration, and differentiation. Among the ECM components, type I collagen induces endothelial tube formation in vitro. By analysing genes participating in this event, the bone morphogenetic protein receptor-II (BMPR-II) was d...

journal_title：Biochemical and biophysical research communications

authors： Regazzoni C,Winterhalter KH,Rohrer L

更新日期：2001-05-04 00:00:00

abstract：:In the present study, we characterized two new SF-1 binding sites, SF-209 and SF-98, in the promoter of the human ACTH receptor (hACTH-R) gene. Both sites, together with the previously described SF-35 site, are required for full constitutive activity of this gene. This was demonstrated by the use of constructs contain...

journal_title：Biochemical and biophysical research communications

authors： Naville D,Penhoat A,Durand P,Begeot M

更新日期：1999-02-05 00:00:00

abstract：:The lipase from Malassezia globosa (SMG1) was identified to be strictly specific for mono- and diacylglycerol but not triacylglycerol. The crystal structures of SMG1 were solved in the closed conformation, but they failed to provide direct evidence of factors responsible for this unique selectivity. To address this pr...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Gao C,Lan D,Yang B,Wang Y

更新日期：2012-07-27 00:00:00

abstract：:Connexin 43 (Cx43)-hemichannel activity is controlled by intramolecular interactions between cytoplasmic loop and C-terminal tail. We previously identified the last 10 amino acids of the C-terminal tail of Cx43 as essential for Cx43-hemichannel activity. We developed a cell-permeable peptide covering this sequence (TA...

journal_title：Biochemical and biophysical research communications

authors： D'hondt C,Iyyathurai J,Wang N,Gourdie RG,Himpens B,Leybaert L,Bultynck G

更新日期：2013-03-22 00:00:00

abstract：:Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally exp...

journal_title：Biochemical and biophysical research communications

authors： Huang SJ,Yang WS,Lin YW,Wang HC,Chen CC

更新日期：2008-07-11 00:00:00

abstract：:The synthetic-peptide strategy was used to generate antibodies raised against calcium-dependent lectins of vertebrates. We demonstrate that a synthetic peptide predicted from the amino acid sequence of the carbohydrate recognition domain can induce blocking antibodies which would react with, or in close vicinity of, t...

journal_title：Biochemical and biophysical research communications

authors： Blanck O,Thibault V,Granier C,Van Rietschoten J,Courageot J,Miquelis R

更新日期：1990-06-29 00:00:00

abstract：:The aim of current study was to elucidate whether aquaporin-9 (AQP9) expression was involved in the progression of bone loss induced by microgravity. We used the hind-limb suspension (HLS) mice model to simulate microgravity and induce bone loss. It was found that HLS exposure decreased femur bone mineral density (BMD...

journal_title：Biochemical and biophysical research communications

authors： Bu G,Shuang F,Wu Y,Ren D,Hou S

更新日期：2012-03-23 00:00:00

abstract：:The cardiovascular system operates under demands ranging from conditions of rest to extreme stress. One mechanism of cardiac stress tolerance is action potential duration shortening driven by ATP-sensitive potassium (K(ATP)) channels. K(ATP) channel expression has a significant physiologic impact on action potential d...

journal_title：Biochemical and biophysical research communications

authors： Zhu Z,Burnett CM,Maksymov G,Stepniak E,Sierra A,Subbotina E,Anderson ME,Coetzee WA,Hodgson-Zingman DM,Zingman LV

更新日期：2011-12-02 00:00:00

abstract：:A comparative study was conducted between the antiherpetic agents 2'-nor-2'-deoxyguanosine (2'NDG) and acyclovir (ACV) with respect to 1) the relative rates of uptake and phosphorylation to the "active" triphosphate species in tissue culture and 2) the in vitro inhibition of viral and cellular DNA polymerases by their...

journal_title：Biochemical and biophysical research communications

authors： Germershausen J,Bostedor R,Field AK,Perry H,Liou R,Bull H,Tolman RL,Karkas JD

更新日期：1983-10-31 00:00:00

abstract：:By performing immunofluorescence staining assays in confluent COS-7 cells, hepatitis B virus core, small surface and large surface proteins were found to localize largely in the nucleus, diffusely in the cytoplasm, and accumulatively in a perinuclear area, respectively. When two proteins were co-expressed, the core pr...

journal_title：Biochemical and biophysical research communications

authors： Yeh CT,Ou JH,Chu CM,Liaw YF

更新日期：1994-09-15 00:00:00

abstract：:In this study, we calculate the unpredictable portion of amino-acid pairs, which has been developed by us over the last several years, of 1201 hemagglutinins from influenza A viruses dated from 1918 to 2004 in order to compare them with respect to subtypes, species, and years. After noticing the fluctuations of unpred...

journal_title：Biochemical and biophysical research communications

authors： Wu G,Yan S

更新日期：2005-07-22 00:00:00

abstract：:Ugp1, UDP-glucose pyrophosphorylase, plays an important role in carbohydrate metabolism because it provides UDP-glucose that is a pivotal metabolite in several metabolic pathways in Saccharomyces cerevisiae. In this study, we show that a considerable reduction of glycogen and trehalose content in ugp1 knockdown cells ...

journal_title：Biochemical and biophysical research communications

authors： Yi DG,Huh WK

更新日期：2015-11-27 00:00:00

abstract：:Chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase was expressed in E. coli by using a pET3a T7 RNA polymerase-based expression system and was purified to homogeneity. The kinase and bisphosphatase of the expressed bifunctional enzyme had kinetic properties identical to those of the native chicken live...

journal_title：Biochemical and biophysical research communications

authors： Li L,Yao WZ,Lange AJ,Pilkis SJ,Dong MQ,Yin Y,Xu GJ

更新日期：1995-04-26 00:00:00

abstract：:Previous studies have shown that high-fat diet (HFD)-induced obesity increases the acetoacetyl-CoA synthetase (AACS) gene expression in lipogenic tissue. To investigate the effect of obesity on the AACS gene in other tissues, we examined the alteration of AACS mRNA levels in HFD-fed mice. In situ hybridization reveale...

journal_title：Biochemical and biophysical research communications

authors： Yamasaki M,Hasegawa S,Imai M,Takahashi N,Fukui T

更新日期：2016-04-29 00:00:00

abstract：:Several preclinical studies have revealed antidepressant and anxiolytic-like effect of 5-HT3 receptor antagonists. In our earlier study, we have reported the antidepressive-like effect of 3-methoxy-N-p-tolylquinoxalin-2-carboxamide (QCM-4) in obese mice subjected to chronic stress. The present study deals with the bio...

journal_title：Biochemical and biophysical research communications

authors： Kurhe Y,Mahesh R,Devadoss T

更新日期：2015-01-02 00:00:00