Two novel tachykinin-related neuropeptides in the echiuroid worm, Urechis unicinctus.

abstract：:To investigate the structural basis for human interferon gamma (huIFN gamma) binding to intracellular regions of the human IFN gamma receptor (huIFN gamma R), we have subcloned and expressed the huIFN gamma R free of fusion proteins in the yeast strain Pichia pastoris. HuIFN gamma bound to the cytoplasmic domain of th...

journal_title：Biochemical and biophysical research communications

authors： Green MM,Larkin J 3rd,Subramaniam PS,Szente BE,Johnson HM

更新日期：1998-02-04 00:00:00

abstract：:The extracellular microenvironment plays a key role in regulation of cellular functions and growth control. We show here that membrane-type 1 matrix metalloproteinase (MT1-MMP) acts as a growth promoter in confluent culture. When MT1-MMP was silenced in HT1080 fibrosarcoma cells, cells created three dimensional (3D) f...

journal_title：Biochemical and biophysical research communications

authors： Takino T,Guo L,Domoto T,Sato H

更新日期：2013-07-05 00:00:00

abstract：:The Crk and CrkL adaptor proteins have SH2 and SH3 domains and play essential overlapping, as well as distinct, roles in many biological processes, ranging from cell structure and motility to proliferation. Conditional ablation of both Crk and CrkL in neuronal progenitor cells, using a Nestin-Cre transgene, resulted i...

journal_title：Biochemical and biophysical research communications

authors： Park T,Curran T

更新日期：2020-08-27 00:00:00

abstract：:The phthalate ester insensitive blue-green algae (Synechococcus lividus) were used as a food source to extend the survival of synchronously hatched brine shrimp (Artemia salina) larvae allowing measurement of a reduced toxic response to phthalate esters at late post-hatching stages of development. The maximum acute to...

journal_title：Biochemical and biophysical research communications

authors： Acey RA,Bailey S,Healy P,Jo C,Unger TF,Hudson RA

更新日期：2002-12-13 00:00:00

abstract：:GTP cyclohydrolase I (GTPCH) is the first and rate-limiting enzyme for the synthesis of tetrahydrobiopterin (BH4), a cofactor of nitric oxide synthase (NOS). As the induction of NO synthesis by immunostimulants in vascular smooth muscle (VSM) cells requires de novo synthesis of BH4, we investigated whether immunostimu...

journal_title：Biochemical and biophysical research communications

authors： Hattori Y,Gross SS

更新日期：1993-08-31 00:00:00

abstract：:Cellular prion protein (PrP(C)) is expressed not only in neuronal cells but also in non-neuronal cells such as astroglial cells. In the present study, the prion protein (PrP) gene (Prnp)-deficient astroglial cell line GpL1 from hippocampal cells of ZrchI Prnp(-/-) mice were established. Transfection of Prnp suppressed...

journal_title：Biochemical and biophysical research communications

authors： Nishimura T,Sakudo A,Xue G,Ikuta K,Yukawa M,Sugiura K,Onodera T

更新日期：2008-12-26 00:00:00

abstract：:Specific anatomical sites and pathways responsible for mediating metabolic and neuroendocrine effects of leptin are still poorly understood. Therefore, we examined distribution of leptin receptor-containing neurons transsynaptically connected with the porcine fat tissue by means of combined viral transneuronal tracing...

journal_title：Biochemical and biophysical research communications

authors： Czaja K,Kraeling RR,Barb CR

更新日期：2003-11-14 00:00:00

abstract：:Aberrant expression of cell cycle regulators have been implicated in prostate cancer development and progression. Therefore, understanding transcriptional networks controlling the cell cycle remain a challenge in the development of prostate cancer treatment. In this study, we found that icilin, a super-cooling agent, ...

journal_title：Biochemical and biophysical research communications

authors： Lee S,Chun JN,Kim SH,So I,Jeon JH

更新日期：2013-11-29 00:00:00

abstract：:The extended exposure of proteins to reducing sugars leads to nonenzymatic glycation with the accumulation of advanced glycation end products (AGEs). Long-lived proteins, such as collagen and crystallins, are subjected to this modification, and are implicated as causal factors in several diseases including diabetic co...

journal_title：Biochemical and biophysical research communications

authors： Hong SB,Lee KW,Handa JT,Joo CK

更新日期：2000-08-18 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) is a multifunctional growth factor that plays a role in cell proliferation, differentiation, extracellular matrix production, apoptosis, and cell motility. We show here that TGF-beta1 increased the invasiveness of MM1 cells, which are a highly invasive clone of rat ascites ...

journal_title：Biochemical and biophysical research communications

authors： Mukai M,Endo H,Iwasaki T,Tatsuta M,Togawa A,Nakamura H,Inoue M

更新日期：2006-07-21 00:00:00

abstract：:Epinephrine is known to be rapidly oxidized during sepsis. Ischemia and acidosis, which often accompany sepsis, are associated with the release of weakly bound cupric ions from plasma proteins. We investigated whether copper promotes oxidation of epinephrine at both physiological and acidic pH and whether D-Asp-D-Ala-...

journal_title：Biochemical and biophysical research communications

authors： Roberts A,Bar-Or D,Winkler JV,Rael LT

更新日期：2003-05-16 00:00:00

abstract：:betaC-S Lyase catalyzes the alpha,beta-elimination of L-cysteine to hydrogen sulfide, which is one of the main causes of oral malodor and is highly toxic to mammalian cells. We evaluated the capacity of six species of oral streptococci to produce hydrogen sulfide. The crude enzyme extract from Streptococcus anginosus ...

journal_title：Biochemical and biophysical research communications

authors： Yoshida Y,Negishi M,Amano A,Oho T,Nakano Y

更新日期：2003-01-03 00:00:00

abstract：:Porins are trimeric proteins in the outer membranes of Gram-negative bacteria. Several of them, among them matrix porin of Escherichia coli, form symmetrically voltage-gated ion channels in planar bilayers. Trimers exhibit negative resistance at potentials larger than +/- 90mV. Here we show that, after two pores withi...

journal_title：Biochemical and biophysical research communications

authors： Buehler LK,Rosenbusch JP

更新日期：1993-01-29 00:00:00

abstract：:Baicalin (BA) has been shown with anti-HIV-1 activity. Zinc is a nutrient element. The anti-HIV-1 activity of zinc complex of baicalin (BA-Zn) in vitro was studied and compared with the anti-HIV-1 activities between BA and BA-Zn in the present study. Our results suggested that BA-Zn has lower cytotoxicity and higher a...

journal_title：Biochemical and biophysical research communications

authors： Wang Q,Wang YT,Pu SP,Zheng YT

更新日期：2004-11-12 00:00:00

abstract：:alpha 2,6 sialyltransferase towards the N-acetyllactosaminyl sequence (alpha 2,6 ST, E.C. 2.4.99.1) is one of the major sialyltransferases in human colonic cells; it strongly increases in human colorectal tumors and is largely expressed in fetal and neonatal rat colon. In this study we demonstrate that human colon car...

journal_title：Biochemical and biophysical research communications

authors： Dall'Olio F,Malagolini N,Serafini-Cessi F

更新日期：1992-05-15 00:00:00

abstract：:Two novel alpha-neurotoxins, Oh-6A and Oh-6B, isolated from the king cobra (Ophiophagus hannah) venom, consist of 70 amino acid residues with 10 cysteine residues and share the same amino acid sequences as determined by Edman degradation on the peptide fragments generated from the proteolytic hydrolysates. Their seque...

journal_title：Biochemical and biophysical research communications

authors： Lin SR,Chang LS,Chang CC

更新日期：1999-01-08 00:00:00

abstract：:Insulin-like growth factor I stimulates mitogenesis in smooth muscle cells, and upregulates elastin synthesis in embryonic aortic tissue. Increased smooth muscle elastin synthesis may play an important role in vascular remodeling in chronic pulmonary hypertension. Therefore, we studied the effect of IGF-I on elastin a...

journal_title：Biochemical and biophysical research communications

authors： Badesch DB,Lee PD,Parks WC,Stenmark KR

更新日期：1989-04-14 00:00:00

abstract：:The oyster vasa-like gene was previously demonstrated to be specifically expressed in germline cells of adult oysters Crassostrea gigas. In the present study, this gene was used as a molecular marker to establish the developmental pattern of germline cells during oyster ontogenesis, using whole-mount in situ hybridiza...

journal_title：Biochemical and biophysical research communications

authors： Fabioux C,Huvet A,Lelong C,Robert R,Pouvreau S,Daniel JY,Minguant C,Le Pennec M

更新日期：2004-07-23 00:00:00

abstract：:The Rho-associated coiled-coil kinase (ROCK) family of proteins, including ROCK1 and ROCK2, are key regulators of actin and intermediate filament morphology. The newly discovered ROCK substrate Tubulin polymerization promoting protein 1 (TPPP1) promotes microtubule polymerization and inhibits the activity of Histone d...

journal_title：Biochemical and biophysical research communications

authors： Schofield AV,Gamell C,Bernard O

更新日期：2013-07-12 00:00:00

abstract：:Dental fluorosis is characterized by hypomineralization of tooth enamel caused by ingestion of excessive fluoride during enamel formation. Excess fluoride could have effects on the ERK signaling, which is essential for the ameloblasts differentiation and tooth development. MAP kinase phosphatase-1 (MKP-1) plays a crit...

journal_title：Biochemical and biophysical research communications

authors： Zhao L,Su J,Liu S,Li Y,Xi T,Ruan J,Liang KX,Huang R

更新日期：2021-01-22 00:00:00

abstract：:The spontaneous mutant, Wriggle Mouse Sagami (wri), is thought to be a model of hereditary hearing losses in humans. Here we report that the plasma membrane Ca(2+)-ATPase type 2 (PMCA2) gene is mutated in the wri mouse. A G-to-A transition was detected in wri, changing Glu-to-Lys within a conserved transmembrane domai...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Kitamura K

更新日期：1999-08-11 00:00:00

abstract：:Translation of f2am3 RNA and MS2 RNA in a system containing purified ribosomes and precharged aminoacyl-tRNA, does not occur in the presence of the "known" initiation (IF-1, IF-2 and IF-3), elongation (EF-Tu, EF-Ts and EF-G) and termination (RF-1, RF-2) factors. Translation in this system requires at least three addit...

journal_title：Biochemical and biophysical research communications

authors： Green RH,Glick BR,Ganoza MC

更新日期：1985-01-31 00:00:00

abstract：:Using the coding region of the human CK-2 alpha cDNA as a probe for screening a genomic mouse library, positive clones representing four different genomic loci were isolated. Partial DNA sequences of these loci encompassing the first 120 nucleotides of the putative coding region are reported. One positive clone was fu...

journal_title：Biochemical and biophysical research communications

authors： Boldyreff B,Wehr K,Hecht R,Issinger OG

更新日期：1992-07-31 00:00:00

abstract：:Human placental poly(ADP-ribose) polymerase was purified and the NH2-terminal amino acid sequences of 16 KDa and 40 KDa chymotryptic peptides were determined. Screening of a lambda gt11 cDNA library of normal human placenta with a 51-mer oligodeoxyribonucleotide yielded one clone with a 1.8 Kb insert and two clones wi...

journal_title：Biochemical and biophysical research communications

authors： Suzuki H,Uchida K,Shima H,Sato T,Okamoto T,Kimura T,Miwa M

更新日期：1987-07-31 00:00:00

abstract：:Light-induced conformational changes occurring at the cytosolic surface of rhodopsin were investigated by performing limited digestions of native and illuminated visual pigment with thermolysin, Arg-C endoproteinase, papain and proteinase K. A higher susceptibility of the extradiscal regions of the bleached pigment to...

journal_title：Biochemical and biophysical research communications

authors： Pellicone C,Nullans G,Cook NJ,Virmaux N

更新日期：1985-03-29 00:00:00

abstract：:4-Nonylphenol (NP) is reported to have estrogenic activity; however, its influence on cytokine production or immune system function remains unclear. In this study we investigated the effects of NP on the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha), and on the level of inducible nitric o...

journal_title：Biochemical and biophysical research communications

authors： You HJ,Choi CY,Jeon YJ,Chung YC,Kang SK,Hahm KS,Jeong HG

更新日期：2002-06-21 00:00:00

abstract：:Nitric oxide is known to participate in the immune and inflammatory processes. In this study, we investigated the production of nitric oxide (NO) in murine viral myocarditis induced by coxsackievirus B3. The expression of inducible NO synthase (iNOS) mRNA in the heart first appeared on day 4 after virus inoculation an...

journal_title：Biochemical and biophysical research communications

authors： Mikami S,Kawashima S,Kanazawa K,Hirata K,Katayama Y,Hotta H,Hayashi Y,Ito H,Yokoyama M

更新日期：1996-03-27 00:00:00

abstract：:Tyrosine-specific phosphorylated proteins found exclusively on the cell surface of human astrocytomas were previously identified with murine monoclonal antibodies, designated as GA-17, GB-4 and GC-3. The purpose of this study was to further characterize the antigens and investigate the relationship between them and c-...

journal_title：Biochemical and biophysical research communications

authors： Kondo S,Miyatake S,Matsumoto M,Nakatsu S,Iwasaki K,Oda Y,Kikuchi H,Namba Y

更新日期：1992-01-31 00:00:00

abstract：AIM/BACKGROUND:CD99 participate in neutrophil infiltration after inflammatory events; however, despite the important role of inflammation in ischemic stroke, the role of CD99 in ischemic stroke remains unclear. METHOD:In the present study, we detected the protein expression of CD99, ICAM-1, and CD31 (PECAM-1) in oxyge...

journal_title：Biochemical and biophysical research communications

authors： Hu T,Sun R,Huang F,Liu X,Duan Z,Ye R,Li Y,Xiao L,Guo Z,Liu Q,Zhu W

更新日期：2020-06-04 00:00:00

abstract：:Mutant 6B7 of Salmonella enterica serovar Typhimurium has a transposon inserted in the putative transporter gene yjeH and shows a more-than-fourfold reduction in resistance to ceftriaxone. In this report we have used proteomic analysis to compare outer membrane protein profiles between this mutant and its parental str...

journal_title：Biochemical and biophysical research communications

authors： Hu WS,Lin YH,Shih CC

更新日期：2007-09-28 00:00:00