Establishment of a new glial cell line from hippocampus of prion protein gene-deficient mice.

Abstract:

:Cellular prion protein (PrP(C)) is expressed not only in neuronal cells but also in non-neuronal cells such as astroglial cells. In the present study, the prion protein (PrP) gene (Prnp)-deficient astroglial cell line GpL1 from hippocampal cells of ZrchI Prnp(-/-) mice were established. Transfection of Prnp suppressed cell death in GpL1 cells under serum-free conditions. The PrP-expressing GpL1 cells showed increased superoxide dismutase activity compared to control GpL1 cells. These results suggest that the anti-oxidative activity of PrP(C) functions in not only neuronal cells but also astroglial cells possibly due to the increased anti-oxidative activity of astroglial cells.

authors

Nishimura T,Sakudo A,Xue G,Ikuta K,Yukawa M,Sugiura K,Onodera T

doi

10.1016/j.bbrc.2008.10.087

subject

Has Abstract

pub_date

2008-12-26 00:00:00

pages

1047-50

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)02035-4

journal_volume

377

pub_type

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