Light-induced conformational changes in the extradiscal regions of bovine rhodopsin.

abstract：:Chemotaxis of rabbit peritoneal leucocytes stimulated by fMet-Leu-Phe, a synthetic chemoattractant, was inhibited by Glu-Glu-Glu-Glu-Tyr-Pro-Met-Glu (MT peptide) and Leu-Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Glu-Gly (Src peptide). Both peptides did not inhibit the binding of [3H] formyl-NLe-Leu-Phe, a chemoattractant, t...

journal_title：Biochemical and biophysical research communications

authors： Hirata F,Notsu Y,Matsuda K,Vasanthakumar G,Schiffmann E,Wong TW,Goldberg AR

更新日期：1984-01-30 00:00:00

abstract：:Metformin, a widely used anti-diabetic drug, is emerging as a potential anticancer agent but the mechanisms involved remain incompletely understood. Here, we demonstrate that the potency of metformin induced AMPK activation, as shown by the phosphorylation of its substrates acetyl-CoA carboxylase (ACC) at Ser(79) and ...

journal_title：Biochemical and biophysical research communications

authors： Sinnett-Smith J,Kisfalvi K,Kui R,Rozengurt E

更新日期：2013-01-04 00:00:00

abstract：:NO production in platelets has been followed by electrochemical detection. It was undetectable in unstimulated platelets and in thrombin or ADP-stimulated platelets, but dose-dependently stimulated by collagen. A production of 5 10(-19) mol/platelet was reached with 9 micrograms collagen. In collagen-stimulated platel...

journal_title：Biochemical and biophysical research communications

authors： Lantoine F,Brunet A,Bedioui F,Devynck J,Devynck MA

更新日期：1995-10-24 00:00:00

abstract：:Mutations in collagen II are associated with spondyloepiphyseal dysplasia, a group of heritable diseases whose common features include aberrations of skeletal growth. The mechanisms through which mutations in collagen II affect the cartilaginous tissues are complex and include both intracellular and extracellular proc...

journal_title：Biochemical and biophysical research communications

authors： Gawron K,Jensen DA,Steplewski A,Fertala A

更新日期：2010-05-28 00:00:00

abstract：:A series of C-terminal deleted analogs of human growth hormone-releasing factor (hGRF) with either an amidated or a free carboxylic acid C-terminus were synthesized by solid phase methodology. Their capacity to release growth hormone was tested on rat anterior pituitary cells in monolayer culture. A gradual decrease o...

journal_title：Biochemical and biophysical research communications

authors： Ling N,Baird A,Wehrenberg WB,Ueno N,Munegumi T,Brazeau P

更新日期：1984-09-17 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) is upregulated in many cancers, especially neuroblastoma. We set out to explore whether geranylgeranoic acid (GGA) inhibits LSD1 activity by using recombinant human LSD1. GGA inhibited LSD1 activity with IC50 similar to that of the clinically used drug tranylcypromine. In human neu...

journal_title：Biochemical and biophysical research communications

authors： Sakane C,Okitsu T,Wada A,Sagami H,Shidoji Y

更新日期：2014-01-31 00:00:00

abstract：:The non-receptor tyrosine kinases c-Src and focal adhesion kinase (Fak) mediate signal transduction pathways that regulate cell proliferation, survival, invasion, and metastasis. Here, we investigated whether c-Src and Fak are activated during progression of hormone-dependent breast cancer. Maximally active c-Src was ...

journal_title：Biochemical and biophysical research communications

authors： Planas-Silva MD,Bruggeman RD,Grenko RT,Stanley Smith J

更新日期：2006-03-03 00:00:00

abstract：:Pelvic cartilage of chick embryo was used to demonstrate that presence of boron in culture medium decreases synthesis of proteoglycans, collagen and total proteins but on the other hand increases the release of these macromolecules. However, when glucose concentration in culture medium is brought to 22mM, the synthesi...

journal_title：Biochemical and biophysical research communications

authors： Benderdour M,Hess K,Gadet MD,Dousset B,Nabet P,Belleville F

更新日期：1997-05-08 00:00:00

abstract：:Campylobacter jejuni is a bacterium that uses flagella for motility and causes worldwide acute gastroenteritis in humans. The C. jejuni N-acetyltransferase PseH (cjPseH) is responsible for the third step in flagellin O-linked glycosylation and plays a key role in flagellar formation and motility. cjPseH transfers an a...

journal_title：Biochemical and biophysical research communications

authors： Song WS,Nam MS,Namgung B,Yoon SI

更新日期：2015-03-20 00:00:00

abstract：:Perillaldehyde (PAH), one of the major oil components in Perilla frutescens, has anti-inflammatory effects. Few studies have examined the neuroprotective effect of PAH on stroke. So the aim of our study is to investigate the effect of PAH on ischemia-reperfusion-induced injury in the rat brain cortex. Middle cerebral ...

journal_title：Biochemical and biophysical research communications

authors： Xu L,Li Y,Fu Q,Ma S

更新日期：2014-11-07 00:00:00

abstract：:TWIST1, a basic helix-loop-helix transcription factor, plays critical roles in embryo development, cancer metastasis and mesenchymal progenitor differentiation. Little is known about transcriptional regulation of TWIST1 expression. Here we identified DNA sequences responsible for TWIST1 expression in mesenchymal linea...

journal_title：Biochemical and biophysical research communications

authors： Ohkuma M,Funato N,Higashihori N,Murakami M,Ohyama K,Nakamura M

更新日期：2007-01-26 00:00:00

abstract：:Spin-trapping of superoxide ion, O2-, which is produced from two different sources (OH(-)-DMSO and xanthine-xanthine oxidase systems), was investigated by use of a water-soluble, notroso-aromatic spin trap, sodium 3,5-dibromo-4-nitrosobenzene-sulfonate (DBNBS). It was found that O2- from all sources was easily trapped...

journal_title：Biochemical and biophysical research communications

authors： Ozawa T,Hanaki A

更新日期：1986-04-29 00:00:00

abstract：:The large ribosomal subunit of the thermophilic fungus Thermomyces lanuginosus was reconstructed in three dimensions from electron micrographs. This is the first reported reconstruction of the eukaryotic complex and demonstrates specific structural features such as an intersubunit canyon and a potential channel for th...

journal_title：Biochemical and biophysical research communications

authors： Harauz G,Zuzan H,Kim PT,Holbrook JA

更新日期：1995-02-15 00:00:00

abstract：:In Chinese hamster ovary cells, [3H]formycin B is metabolized into formycin B-5'-monophosphate, formycin A-5'-monophosphate and higher phosphorylated derivatives of formycin A which are incorporated into RNA. Mutants of CHO cells independently selected for resistance to various adenosine analogs viz. toyocamycin, tube...

journal_title：Biochemical and biophysical research communications

authors： Mehta KD,Gupta RS

更新日期：1985-07-31 00:00:00

abstract：:The Fru-6-P/Fru-2,6-P2 exchange reaction of rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase was almost entirely dependent on the presence of Pi. This exchange was not due to a reversal of the bisphosphatase nor to trace amounts of adenine nucleotide in the enzyme. Exchange activity was maximal at pH 7, ...

journal_title：Biochemical and biophysical research communications

authors： El-Maghrabi MR,Pate TM,Pilkis SJ

更新日期：1984-09-17 00:00:00

abstract：:Adenylate cyclase in homogenates of guinea pig ventricles was inhibited by the stable adenosine analogs N6-phenylisopropyladenosine (PIA) and 5(1)-N-ethylcarboxamidoadenosine (NECA). Inhibition required GTP and was enhanced by sodium ion. The maximum inhibition observed was 35.1 +/- 1.1%, the EC50 (95% confidence limi...

journal_title：Biochemical and biophysical research communications

authors： Leung E,Johnston CI,Woodcock EA

更新日期：1983-01-14 00:00:00

abstract：:With aging and stress, the myocardium undergoes structural remodeling, often leading to fibrosis. The purpose of this study is to examine whether lumican, one of the class II small leucine-rich proteoglycans, has a protective role in cardiac remodeling and fibrosis. In attempts to elucidate the hypothesis that lumican...

journal_title：Biochemical and biophysical research communications

authors： Chen SW,Tung YC,Jung SM,Chu Y,Lin PJ,Kao WW,Chu PH

更新日期：2017-01-22 00:00:00

abstract：:A well-established feature of the translation initiation region, which attracts the ribosomes to the prokaryotic mRNAs, is a purine rich area called Shine/Dalgarno sequence (SD). There are examples of various other sequences, which despite having no similarity to an SD sequence are capable of enhancing and/or initiati...

journal_title：Biochemical and biophysical research communications

authors： Golshani A,Krogan NJ,Xu J,Pacal M,Yang XC,Ivanov I,Providenti MA,Ganoza MC,Ivanov IG,AbouHaidar MG

更新日期：2004-04-16 00:00:00

abstract：:Intracellular B(12) metabolism involves a B(12) trafficking chaperone CblC that is well conserved in mammals including human. The protein CblC is known to bind cyanocobalamin (CNCbl, vitamin B(12)) inducing the base-off transition and convert it into an intermediate that can be used in enzyme cofactor synthesis. The b...

journal_title：Biochemical and biophysical research communications

authors： Jeong J,Kim J

更新日期：2011-08-26 00:00:00

abstract：:Pro-inflammatory cytokines contribute to pancreatic beta cell death in the pathogenesis of type 1 diabetes mellitus (DM). Cytochrome P450-derived epoxyeicosatrienoic acids (EETs), produced by selective epoxidation of arachidonic acid, display anti-inflammatory activity in numerous disease models, in part through inhib...

journal_title：Biochemical and biophysical research communications

authors： Grimes D,Watson D

更新日期：2019-12-03 00:00:00

abstract：:Aberrant activation of the Wnt/β-catenin signaling pathway is common in human cervical cancers and has great potential therapeutic value. We show that tigecycline, a FDA-approved antibiotic drug, targets cervical squamous cell carcinoma through inhibiting Wnt/β-catenin signaling pathway. Tigecycline is effective in in...

journal_title：Biochemical and biophysical research communications

authors： Li H,Jiao S,Li X,Banu H,Hamal S,Wang X

更新日期：2015-11-06 00:00:00

abstract：:The molecular basis for group I metabotropic glutamate receptors (mGluR1 and 5) coupling to membrane ion channels and intracellular calcium pools is not fully understood. Homer is a family of post synaptic density proteins functionally and physically attached to target proteins at proline-rich sequences. In the presen...

journal_title：Biochemical and biophysical research communications

authors： Lv MM,Cheng YC,Xiao ZB,Sun MY,Ren PC,Sun XD

更新日期：2014-08-08 00:00:00

abstract：:We have isolated calpromotin, a protein reported abundant in human red cells and shown to be of significance for KCl transport. We show that calpromotin is identical to a radical scavenger protein, thiol-specific antioxidant protein (TSA). Calpromotin is known to exist partially as a large complex of identical subunit...

journal_title：Biochemical and biophysical research communications

authors： Kristensen P,Rasmussen DE,Kristensen BI

更新日期：1999-08-19 00:00:00

abstract：:Inhibitors of poly(ADP-ribose) synthetase, namely nicotinamide, benzamide, m-methoxybenzamide and 3-aminobenzamide, augmented chondrocytic differentiation chick embryo limb bud mesenchymal cells, in culture. These inhibitors stimulated early appearance and massive formation of cartilage nodules in micromass cultures s...

journal_title：Biochemical and biophysical research communications

authors： Nishio A,Nakanishi S,Doull J,Uyeki EM

更新日期：1983-03-16 00:00:00

abstract：:Phosphofructokinase-2 from rat liver is inhibited by phosphoenolpyruvate and ADP. Phosphoenolpyruvate reduces the maximum activity in respect to fructose-6-phosphate and ATP but does not give rise to complete inhibition of phosphofructokinase-2. ADP increases the apparent Michaelis constant of the enzyme for ATP and l...

journal_title：Biochemical and biophysical research communications

authors： Kretschmer M,Hofmann E

更新日期：1984-11-14 00:00:00

abstract：:We cloned and sequenced a full-length cDNA of human placental N-acetylgalactosamine-6-sulfate sulfatase, the enzyme deficient in Morquio disease. The 2339-nucleotide sequence contained 1566 nucleotides which encoded a polypeptide of 522 amino acid residues. The deduced amino acid sequence was composed of a 26-amino ac...

journal_title：Biochemical and biophysical research communications

authors： Tomatsu S,Fukuda S,Masue M,Sukegawa K,Fukao T,Yamagishi A,Hori T,Iwata H,Ogawa T,Nakashima Y

更新日期：1991-12-16 00:00:00

abstract：:The products of the TSC1 (hamartin) and TCS2 (tuberin) tumor suppressor genes negatively regulate cell growth by inhibiting mTOR signaling. Recent research has led to the postulation that tuberin and/or hamartin are involved in tumor migration, presumably through Rho activation. Here we show that LEF-8 cells, which co...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Das SK,Inoue H,Kazami M,Hino O,Kobayashi T,Yeung RS,Kobayashi K,Tadokoro T,Yamamoto Y

更新日期：2008-03-28 00:00:00

abstract：:In plants, a number of MAP kinase (MAPK), MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK) homologues have been reported. However, there have been no reports of protein-protein interactions between these kinases or molecular analysis of MAPK cascades in higher plants. To analyze a possible MAPK cascade in Arabidopsis th...

journal_title：Biochemical and biophysical research communications

authors： Ichimura K,Mizoguchi T,Irie K,Morris P,Giraudat J,Matsumoto K,Shinozaki K

更新日期：1998-12-18 00:00:00

abstract：:The cyclin-dependent kinase (CDK) inhibitor p18 blocks progression of the cell cycle by associating with the cyclin D-dependent kinases CDK6 and CDK4. To better understand the regulation of p18 gene expression, we isolated full-length cDNA clones from a human BT-20 breast cancer cell cDNA library. These clones were th...

journal_title：Biochemical and biophysical research communications

authors： Blais A,Labrie Y,Pouliot F,Lachance Y,Labrie C

更新日期：1998-06-09 00:00:00

abstract：:In our efforts to identify immunoreactive antigens in ovarian cancer, we used the method of immunoscreening of an ovarian carcinoma cDNA expression library with ascites fluid from ovarian cancer patients. Among many positive clones, one was found to contain partial sequence of a novel gene. By searching expressed sequ...

journal_title：Biochemical and biophysical research communications

authors： Luo LY,Soosaipillai A,Diamandis EP

更新日期：2001-01-12 00:00:00