Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer.

abstract：:To investigate the role of the carboxyl group in deltorphin molecules, we have synthesized three new analogues in which the acidic amino acid residues in position 4 of the deltorphins were replaced by non-acidic but hydrophilic amino acids residues. The three analogues, [Ser4]-, [Gln4]-, and [Cys4]-deltorphin, all are...

journal_title：Biochemical and biophysical research communications

authors： Misicka A,Lipkowski AW,Fang L,Knapp RJ,Davis P,Kramer T,Burks TF,Yamamura HI,Carr DB,Hruby VJ

更新日期：1991-11-14 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels assembled from four subunits that each have a common membrane topology. The intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least conserved between subunits, and binds multiple intracellular proteins. We defined ...

journal_title：Biochemical and biophysical research communications

authors： Bajaj G,Hau AM,Hsu P,Gafken PR,Schimerlik MI,Ishmael JE

更新日期：2014-02-21 00:00:00

abstract：:Whether alcohol-induced heart failure is caused by a direct toxic effect of ethanol, metabolites, or whether it is a secondary result of neurohumoral, hormonal, or nutritional factors is not clear. To address this question a Langendorff retrograde coronary perfusion model of rat heart was used to study the effect of 0...

journal_title：Biochemical and biophysical research communications

authors： Jänkälä H,Eklund KK,Kokkonen JO,Kovanen PT,Linstedt KA,Härkönen M,Mäki T

更新日期：2001-02-23 00:00:00

abstract：:Platelet activating factor was isolated from the lesional scale of psoriatic patients using the method described by Bligh and Dyer (8). The extract was subjected to thin layer chromatography, and the region of the plate co-migrating with platelet activating factor removed. A portion of each sample was assayed for aggr...

journal_title：Biochemical and biophysical research communications

authors： Mallet AI,Cunningham FM

更新日期：1985-01-16 00:00:00

abstract：:A fractionation of the membrane extract of rat testes revealed the existence of pp60c-src kinase activity. The expression of pp60c-src was examined in the developing rat testes. The immunecomplex kinase assay using a monoclonal antibody specific to pp60c-src (mAb327) showed that the expression of pp60c-src kinase acti...

journal_title：Biochemical and biophysical research communications

authors： Nishio H,Tokuda M,Itano T,Matsui H,Takeuchi Y,Hatase O

更新日期：1995-01-17 00:00:00

abstract：:An ubiquinone-binding protein (QP) was purified from mitochondrial NADH-ubiquinone reductase (Complex I). Complex I was separated into 3 fragments: a fraction of hydrophobic proteins, that of soluble iron-sulfur protein (IP) and soluble NADH dehydrogenase of flavoprotein by a procedure involving the resolution with DO...

journal_title：Biochemical and biophysical research communications

authors： Suzuki H,Ozawa T

更新日期：1986-08-14 00:00:00

abstract：:The reaction of partially purified human O6-alkylguanine-DNA alkyltransferase with 1,3-bis(2-chloroethyl)-1-nitrosourea-treated DNA resulted in formation of a DNA-protein covalent complex. Complex formation required active alkyltransferase and brief treatment of DNA with the drug. DNA lost its capacity to form the com...

journal_title：Biochemical and biophysical research communications

authors： Brent TP,Smith DG,Remack JS

更新日期：1987-01-30 00:00:00

abstract：:Zinc-finger antiviral protein (ZAP) is a recently isolated host antiviral factor that inhibits the replication of many viruses such as Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing the accumulation of viral mRNA in the cytoplasm. ZAP comprises four CCCH zinc-finger motifs, the second and fo...

journal_title：Biochemical and biophysical research communications

authors： Jeong MS,Kim EJ,Jang SB

更新日期：2010-06-04 00:00:00

abstract：:In addition to dimerization and polymerization of samples as previously suggested, it appears that during FAB-MS, reactions in the sample matrix can occur to yield new compounds that are recombinations of molecular fragments. This type of reaction may be especially critical to the integrity of peptide sequencing using...

journal_title：Biochemical and biophysical research communications

authors： Kurlansik L,Williams TJ,Campana JE,Green BN,Anderson LW,Strong JM

更新日期：1983-03-16 00:00:00

abstract：:The induction of human BiP/GRP78 and GAPDH protein genes by the calcium ionophore A23187 was determined. Steady-state levels of mRNA for both the glucose starvation-responsive BiP/GRP78 gene and the glucose-responsive GAPDH gene were dramatically induced in a variety of human cells. There is a homologous palindromatic...

journal_title：Biochemical and biophysical research communications

authors： Chao CC,Yam WC,Lin-Chao S

更新日期：1990-08-31 00:00:00

abstract：:In addition to its interaction at hypothalamic sites to affect feeding and energy expenditure, leptin has been shown to exhibit a proliferative response in erythropoietic cells. The functional leptin receptor is also present in pancreatic islets and we now demonstrate that a commonly used clonal insulin secreting beta...

journal_title：Biochemical and biophysical research communications

authors： Islam MS,Morton NM,Hansson A,Emilsson V

更新日期：1997-09-29 00:00:00

abstract：:The three mammalian Raf proteins (A-Raf, B-Raf, and C-Raf) are key components of the MAPK pathway. Although diverse functions have been proposed for Raf kinases, it is still not clear how interacting proteins contribute to differences in the signaling functions of the three Raf kinases. Here, we report the comparative...

journal_title：Biochemical and biophysical research communications

authors： Zhang XY,Guo H,Huang Y,Hao PQ,Yang Y,Liu Y,Guo XX,Hao Q,An S,Xu TR

更新日期：2019-07-05 00:00:00

abstract：:The effect of calcitonin gene-related peptide(CGRP) on the release of atrial natriuretic peptide(ANP) was studied in spontaneously beating, isolated rat atria. CGRP stimulated the ANP release in a dose-dependent manner. When the atria were incubated with a combination of phentolamine, propranolol, and atropine, these ...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto A,Kimura S,Hasui K,Fujisawa Y,Tamaki T,Fukui K,Iwao H,Abe Y

更新日期：1988-09-30 00:00:00

abstract：:Pyruvate kinase M2 (PKM2) functions as an important rate-limiting enzyme of aerobic glycolysis that is involved in tumor initiation and progression. However, there are few studies on effective PKM2 inhibitors. Gliotoxin is a marine-derived fungal secondary metabolite with multiple biological activities, including immu...

journal_title：Biochemical and biophysical research communications

authors： Tang W,Liu ZL,Mai XY,Qi X,Li DH,Gu QQ,Li J

更新日期：2020-07-30 00:00:00

abstract：:Heme oxygenase cleaves heme to form biliverdin, carbon monoxide (CO), and iron, and consists of two structurally related isozymes, HO-1 and HO-2. HO-2 is also known as a potential oxygen sensor. Here we show that the relative CO content in arterial blood, which reflects the total amount of endogenous heme degradation,...

journal_title：Biochemical and biophysical research communications

authors： Han F,Takeda K,Yokoyama S,Ueda H,Shinozawa Y,Furuyama K,Shibahara S

更新日期：2005-12-09 00:00:00

abstract：:To analyse the species of genes expressed in a cleavage stage mouse embryo, we have constructed a cDNA library containing 3.0 x 10(5) independent clones from about 2 x 10(3) embryos at the 8-cell stage of development. Endo A cDNA prepared from parietal yolk sac endoderm like PYS-2 cells was used to screen the library....

journal_title：Biochemical and biophysical research communications

authors： Nozaki M,Murata K,Morita T,Matsushiro A

更新日期：1988-08-15 00:00:00

abstract：:The observation that spermine inhibits the endotoxin (lipopolysaccharide; LPS) induced production of nitric oxide (NO) in macrophages has been ascribed to the conversion of SP to active metabolites by the action of enzymes, such as diamine oxidases, found, for example, in bovine sera. Inhibitory effect is also observe...

journal_title：Biochemical and biophysical research communications

authors： Southan GJ,Szabó C,Thiemermann C

更新日期：1994-09-30 00:00:00

abstract：:An endopeptidase capable of metabolizing a number of neuropeptides and generating [Met5] and [Leu5] enkephalin from enkephalin-containing peptides is secreted by glioma C6 cells. This neutral endopeptidase that is likely to be a thiol protease, has a Mr of 71KDa and is effective only towards oligopeptides. Its specifi...

journal_title：Biochemical and biophysical research communications

authors： Ferro ES,Tambourgi DV,Gobersztejn F,Gomes MD,Sucupira M,Armelin MC,Kipnis TL,Camargo AC

更新日期：1993-02-26 00:00:00

abstract：:The proliferation promoting activity of various proteolytic fragments of human plasma fibronectin was assayed. Study of this activity in fragments, purified by affinity chromatography, has shown that only heparin-binding fragments were capable of promoting fibroblast proliferation while gelatin- and fibrin-binding fra...

journal_title：Biochemical and biophysical research communications

authors： Zlatopolsky AD,Chubukina AN,Berman AE

更新日期：1992-03-16 00:00:00

abstract：:The effects of 1 microM concentrations of arachidonic acid hydroperoxide (HPETES) products of 5-, 12- and 15-lipoxygenase on Na+, K(+)-ATPase activity were investigated in synaptosomal membrane preparations from rat cerebral cortex. 5-HPETE inhibited Na+, K(+)-ATPase activity by up to 67 %. In contrast, 12-HPETE and 1...

journal_title：Biochemical and biophysical research communications

authors： Foley TD

更新日期：1997-06-18 00:00:00

abstract：:Bolus intravenous injection of arachidonic acid (10 mg/kg) in the rat led to the appearance of hepoxilin A3 in the circulation. The product was assayed as the Me t-BDMSi derivative of its stable trihydroxy product trioxilin A3, by capillary gas chromatography-electron impact mass spectrometry using the stable deuteriu...

journal_title：Biochemical and biophysical research communications

authors： Pace-Asciak CR,Lee SP,Martin JM

更新日期：1987-09-30 00:00:00

abstract：:Vaspin, an adipocytokine recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. However, the exact mechanism underlying this action has not been fully elucidated. Furthermore, the specific function of vaspin is largely unknown, especially in vascular cells. We ...

journal_title：Biochemical and biophysical research communications

authors： Jung CH,Lee WJ,Hwang JY,Seol SM,Kim YM,Lee YL,Park JY

更新日期：2011-09-23 00:00:00

abstract：:A method has been developed for the specific amplification and cloning of human hprt cDNA which can be used for mutant sequence analysis. Messenger RNA is isolated from TK6 lymphoblasts and is used to produce a first strand cDNA with reverse transcriptase primed with oligo dT. Second strand synthesis and subsequent am...

journal_title：Biochemical and biophysical research communications

authors： Simpson D,Crosby RM,Skopek TR

更新日期：1988-02-29 00:00:00

abstract：:We identified human decapping enzyme 2 (hDCP2) as a binding protein with Ro52, being colocalized in processing bodies (p-bodies). We also showed that the N-terminus and C-terminus of Ro52 bound to hDCP2. Moreover, Ro52 enhanced decapping activity of hDCP2 in a dose-dependent manner. Our data support the novel notion o...

journal_title：Biochemical and biophysical research communications

authors： Yamochi T,Ohnuma K,Hosono O,Tanaka H,Kanai Y,Morimoto C

更新日期：2008-05-23 00:00:00

abstract：:The production rate of dengue viruses (DENVs), especially low-passage virus isolates, is low, and, therefore, the isolates are generally used only after several passages. However, in vitro passages could induce mutation(s). In this study, we established a system for the characterization of low-passage viral isolates u...

journal_title：Biochemical and biophysical research communications

authors： Kurosu T,Khamlert C,Phanthanawiboon S,Ikuta K,Anantapreecha S

更新日期：2010-04-02 00:00:00

abstract：:Extracellular vesicles (EVs) play an important role in biological functions and may feature innate therapeutic potential for diseases. In the present study, EVs released by osteoblasts at different stages of the mineralization process were investigated for their potential ability to promote bone formation. Results sho...

journal_title：Biochemical and biophysical research communications

authors： Wei Y,Tang C,Zhang J,Li Z,Zhang X,Miron RJ,Zhang Y

更新日期：2019-06-18 00:00:00

abstract：:DENN domains are found in a variety of signaling proteins but their exact function remains undefined. Some of the DENN-containing proteins, such as rat Rab3GEP (Rab3 GDP/GTP exchange protein) or mouse Rab6IP1 (Rab6 interacting protein 1) interact with GTPases of the Rab family. Others, such as human MADD (MAP (Mitogen...

journal_title：Biochemical and biophysical research communications

authors： Levivier E,Goud B,Souchet M,Calmels TP,Mornon JP,Callebaut I

更新日期：2001-09-28 00:00:00

abstract：:Alveolar rhabdomyosarcoma (aRMS) is a very aggressive sarcoma of children and young adults. Our previous studies have shown that small molecule inhibition of Pdgfra is initially very effective in an aRMS mouse model. However, slowly evolving, acquired resistance to a narrow-spectrum kinase inhibitor (imatinib) was com...

journal_title：Biochemical and biophysical research communications

authors： Abraham J,Chua YX,Glover JM,Tyner JW,Loriaux MM,Kilcoyne A,Giles FJ,Nelon LD,Carew JS,Ouyang Y,Michalek JE,Pal R,Druker BJ,Rubin BP,Keller C

更新日期：2012-09-28 00:00:00

abstract：:Most vertebrates possess at least two gonadotropin-releasing hormone (GnRH) neuron types. To understand the physiological significance of the multiple GnRH systems in the brain, we examined three GnRH neuron type-specific transcriptomes using single-cell microarray analyses in the medaka (Oryzias latipes). A microarra...

journal_title：Biochemical and biophysical research communications

authors： Moriya S,Ogawa S,Parhar IS

更新日期：2013-06-14 00:00:00

abstract：:Down syndrome (DS, Trisomy 21) is the most common genetic cause of delayed fetal brain development and postnatal intellectual disability. Although delayed fetal brain development might be involved in intellectual disability, no evidence of an association between these abnormal phenotypes has been shown. To identify mo...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Ishihara K,Kawashita E,Sago H,Yamakawa K,Mizutani KI,Akiba S

更新日期：2021-01-08 00:00:00