Reciprocal modulation of insulin and insulin-like growth factor-I receptor affinity by calcium.

abstract：:Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, mediates synaptic cell adhesion. Missense mutations in the CADM1 gene have been identified in autism spectrum disorder (ASD) patients. In the present study, we examined emotional behaviors, social behaviors and motor performances in Cadm1-kn...

journal_title：Biochemical and biophysical research communications

authors： Takayanagi Y,Fujita E,Yu Z,Yamagata T,Momoi MY,Momoi T,Onaka T

更新日期：2010-06-04 00:00:00

abstract：:We compared the nitric oxide (NO)-generating behavior of nitroglycerin (NTG), pentaerythritol trinitrate (PEtriN) and isosorbide dinitrate (ISDN), in the microsomal preparation of bovine coronary artery smooth muscle cells. The comparative NO generating activities among these nitrates were consistent with their relati...

journal_title：Biochemical and biophysical research communications

authors： Chung SJ,Fung HL

更新日期：1992-06-30 00:00:00

abstract：:Glycyrrhetinic acid (GA), a triterpene saponins, has been widely proven to have multiple medicinal properties. Our study aimed to figure out the protective effect of GA on acute lung injury (ALI) and the underlying mechanism. The LPS-induced ALI model mice were intratracheally administrated with 10 mg/kg LPS. Pretreat...

journal_title：Biochemical and biophysical research communications

authors： Wang K,Zhang Y,Cao Y,Shi Z,Lin Y,Chen Y,Zhao H,Liu X

更新日期：2020-11-19 00:00:00

abstract：:Neurodegenerative diseases are characterized by distinctive neuropathological alterations, including the cerebral accumulation of misfolded protein aggregates, neuroinflammation, synaptic dysfunction, and neuronal loss, along with behavioral impairments. Traumatic brain injury (TBI) is believed to be an important risk...

journal_title：Biochemical and biophysical research communications

authors： Edwards G 3rd,Moreno-Gonzalez I,Soto C

更新日期：2017-02-19 00:00:00

abstract：:The recent release of COVID-19 spike glycoprotein allows detailed analysis of the structural features that are required for stabilizing the infective form of its quaternary assembly. Trying to disassemble the trimeric structure of COVID-19 spike glycoprotein, we analyzed single protomer surfaces searching for concave ...

journal_title：Biochemical and biophysical research communications

authors： Bongini P,Trezza A,Bianchini M,Spiga O,Niccolai N

更新日期：2020-07-12 00:00:00

abstract：:Expression of vascular endothelial growth factor (VEGF) by cultured vascular smooth muscle cells was analyzed. Serum and hypoxia had nearly additive actions on VEGF mRNA expression. The function of the VEGF promoter in smooth muscle cells was analyzed using transient luciferase reporter assays. Serum and hypoxia stimu...

journal_title：Biochemical and biophysical research communications

authors： D'Angelo G,Ladoux A,Frelin C

更新日期：2000-01-07 00:00:00

abstract：:Glutathione S-transferase Y-2 mRNA synthesis was induced in yeast Issatchenkia orientalis approximately 37-fold by cultivation with o-dinitrobenzene. A cDNA library complementary to poly (A)+RNA of I. orientalis grown with o-dinitrobenzene was screened by colony hybridization. Twenty positive clones were obtained from...

journal_title：Biochemical and biophysical research communications

authors： Tamaki H,Kumagai H,Tochikura T

更新日期：1990-10-30 00:00:00

abstract：:Aging is associated with extensive cognitive impairments, although the biochemical and physiological basis of these deficits are unknown. As the hippocampus plays a vital role in cognitive functions, we have selected this tissue to analyze changes in gene expression at two different ages. Array technology is utilized ...

journal_title：Biochemical and biophysical research communications

authors： Kumar VB,Franko MW,Farr SA,Armbrecht HJ,Morley JE

更新日期：2000-06-16 00:00:00

abstract：:Using a culture system that facilitates osteogenic differentiation of bone marrow-derived human mesenchymal stem cells, we analyzed gene-expression profiles during the mineralization process by means of a cDNA microarray system consisting of 23,040 genes. We compared expression profiles of the cells at days 3, 15, and...

journal_title：Biochemical and biophysical research communications

authors： Doi M,Nagano A,Nakamura Y

更新日期：2002-01-11 00:00:00

abstract：:We previously showed that cor15, a cold-regulated gene from Arabidopsis thaliana, encodes a 15 kDa polypeptide designated COR15. Here we report that COR15 has potent cryoprotective activity in an in vitro cryoprotection assay. Specifically, COR15 was very effective in protecting the cold-labile enzyme lactate dehydrog...

journal_title：Biochemical and biophysical research communications

authors： Lin C,Thomashow MF

更新日期：1992-03-31 00:00:00

abstract：:Angiogenin is a potent angiogenic factor secreted by cultured tumor cells and is found in various normal organs and tissues. The ovary is one of the adult organs in which angiogenesis normally occurs during the female reproductive cycle. In this study, we examined whether angiogenin protein is localized and if angioge...

journal_title：Biochemical and biophysical research communications

authors： Lee HS,Lee IS,Kang TC,Jeong GB,Chang SI

更新日期：1999-04-02 00:00:00

abstract：BACKGROUND:Conventional hepatitis B virus (HBV) vaccines fail to induce protective antibody titers in 5-10% of immune-competent vaccines. Therefore, safe and effective HBV vaccines are still clinically needed. METHODS:In this study, we developed a plasmid DNA vaccine encoding CD317 single-chain fragment variable (α317...

journal_title：Biochemical and biophysical research communications

authors： Zhang G,Li X,Liu L,Li J,Chen Q,Huang S,Li Y,Wan X

更新日期：2018-10-12 00:00:00

abstract：:In Alzheimer's disease (AD), tau protein is abnormally hyperphosphorylated and aggregated into paired helical filaments (PHFs). It was discovered recently that tau is also O-GlcNAcylated in human brains. And O-GlcNAcylation may regulate phosphorylation of tau in a site-specific manner. In this work, we focused on the ...

journal_title：Biochemical and biophysical research communications

authors： Yu CH,Si T,Wu WH,Hu J,Du JT,Zhao YF,Li YM

更新日期：2008-10-10 00:00:00

abstract：:By the use of well-characterized antibodies against porcine dynorphin-A(1-8), an endogenous opioid peptide, and the use of a modified immunofluorescence microscopic technique, dynorphin-A(1-8) stained perikarya, nerve fibres, and nerve terminals were visualized in the rat duodenum. Dynorphin-A(1-8) immunoreactive peri...

journal_title：Biochemical and biophysical research communications

authors： Wolter HJ

更新日期：1985-03-15 00:00:00

abstract：:Bovine aorta endothelial cells were cultured in medium containing [3H]glucosamine, [35S]sulfate, and various concentrations of chlorate. Cell growth was not affected by 10 mM chlorate, while 30 mM chlorate had a slight inhibitory effect. Chlorate concentrations greater than 10 mM resulted in significant undersulfation...

journal_title：Biochemical and biophysical research communications

authors： Humphries DE,Silbert JE

更新日期：1988-07-15 00:00:00

abstract：:Tetrodotoxin-binding sites were covalently labelled with a highly tritiated derivative of tetrodotoxin. Cross-linking experiments, using dissucinimidyl suberate, on partially purified tetrodotoxin-binding component from electroplax of Electrophorus electricus, revealed covalent labelling of a single polypeptide chain ...

journal_title：Biochemical and biophysical research communications

authors： Lombet A,Norman RI,Lazdunski M

更新日期：1983-07-18 00:00:00

abstract：:The product of the spontaneous dimerization and decarboxylation of aminoethylcysteine ketimine (simply named the dimer in this note) has been investigated for a possible biochemical activity. It has been found that the dimer inhibits the ADP-dependent oxidation of NAD(+)-linked substrates in rat liver mitochondria and...

journal_title：Biochemical and biophysical research communications

authors： Pecci L,Montefoschi G,Fontana M,Cavallini D

更新日期：1994-03-15 00:00:00

abstract：:A type II DNA topoisomerase has been partially purified from calf thymus mitochondria by a combination of differential centrifugation and column chromatography. The mitochondrial enzyme was inhibited by amsacrine (m-AMSA) slightly at 0.5 microM, significantly at 5.0 microM, and completely at 50 microM. A similar profi...

journal_title：Biochemical and biophysical research communications

authors： Lin JH,Castora FJ

更新日期：1991-04-30 00:00:00

abstract：:Hepatitis B virus infection is primarily mediated by the interaction of the preS region of the viral envelope protein with its still unknown cellular receptor. Using recombinantly expressed preS proteins, the distribution of preS-binding receptors on cell lines from extrahepatic origins was determined by immunofluores...

journal_title：Biochemical and biophysical research communications

authors： Park JH,Choi EA,Cho EW,Lee YJ,Park JM,Na SY,Kim KL

更新日期：2000-10-14 00:00:00

abstract：:Signaling pathways for the antiviral and antiproliferative biological effects of type I interferons (IFN) are well established. In this report we demonstrate a novel signaling pathway for IFN-alpha, as it induced rapid phosphorylation of both PKB/Akt and its substrate forkhead. The PI3-kinase inhibitor LY294002 abolis...

journal_title：Biochemical and biophysical research communications

authors： Ruuth K,Carlsson L,Hallberg B,Lundgren E

更新日期：2001-06-15 00:00:00

abstract：:The modification of chromatin structure is increasingly recognized to be an important facet of transcriptional regulation. Here, we report that Brahma-related gene 1 (BRG1), a chromatin remodeling enzyme, plays a crucial role in IFN-γ-induced TRIM22 expression. Our results showed that IFN-γ failed to induce TRIM22 exp...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Gao B,Xu W,Xiong S

更新日期：2011-07-08 00:00:00

abstract：:It is considered that the essence of acute lung injury (ALI) is an excessive and uncontrolled inflammatory response in lung, of which mainly is attributed to the release of inflammatory mediators. Recent studies demonstrated that irisin, which is a metabolism associated factor after physical exercise could suppression...

journal_title：Biochemical and biophysical research communications

authors： Shao L,Meng D,Yang F,Song H,Tang D

更新日期：2017-05-27 00:00:00

abstract：:PKCdelta was revealed to make a homologous protein complex that shows a high protein kinase activity upon H(2)O(2) stimulation by expressing the enzymes having different epitope tags in COS-7 cells. The association of the endogenous PKCdelta in the cells was observed by sucrose density gradients. Analysis using the mu...

journal_title：Biochemical and biophysical research communications

authors： Umada-Kajimoto S,Yamamoto T,Matsuzaki H,Kikkawa U

更新日期：2006-03-03 00:00:00

abstract：:The matrix metalloproteinases (MMPs) are a group of enzymes which have the ability to degrade extracellular matrix. They also cleave non-matrix proteins such as myelin basic protein and alpha 1-antitrypsin and they are able to process tumour necrosis factor-alpha (TNF) to its mature form. We have cloned, expressed and...

journal_title：Biochemical and biophysical research communications

authors： Chandler S,Cossins J,Lury J,Wells G

更新日期：1996-11-12 00:00:00

abstract：:Endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are important lipid mediators for immunosuppressive effects and for appropriate homeostasis via their G-protein-coupled cannabinoid (CB) receptors in mammalian organs and tissues, and may be involved in wound healing in some organs. The phys...

journal_title：Biochemical and biophysical research communications

authors： Kozono S,Matsuyama T,Biwasa KK,Kawahara K,Nakajima Y,Yoshimoto T,Yonamine Y,Kadomatsu H,Tancharoen S,Hashiguchi T,Noguchi K,Maruyama I

更新日期：2010-04-16 00:00:00

abstract：:Due to the structural and functional importance of tight turns, some methods have been proposed to predict gamma-turns, beta-turns, and alpha-turns in proteins. In the past, studies of pi-turns were made, but not a single prediction approach has been developed so far. It will be useful to develop a method for identify...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Xue ZD,Shi XH,Xu J

更新日期：2006-09-01 00:00:00

abstract：:Thyrotropin receptor (TSHR) in extrathyroidal tissue, especially fat tissue, is supposed to have important roles in the development of extrathyroidal manifestations of Graves' disease. However, the molecular mechanism of TSHR expression is not known. Expression of TSHR mRNA and TSH-dependent cAMP production were obser...

journal_title：Biochemical and biophysical research communications

authors： Haraguchi K,Shimura H,Lin L,Saito T,Endo T,Onaya T

更新日期：1996-06-05 00:00:00

abstract：:A monoclonal antibody (MaB) against mouse sarcoma DNA polymerase alpha was isolated from the culture medium of an IgG-secreting hybridoma. The MaB demonstrated reactivity against two murine DNA polymerase alpha preparations and a calf thymus DNA polymerase alpha. Murine sarcoma polymerase was activated in vitro by pho...

journal_title：Biochemical and biophysical research communications

authors： Sylvia VL,Norman JO,Curtin GM,Busbee DL

更新日期：1986-11-26 00:00:00

abstract：:Diphtheria toxin is translocated across cellular membranes when receptor-bound toxin is exposed to low pH. To study the role of sphingolipids for toxin translocation, both a mutant cell line lacking the first enzyme in de novo sphingolipid synthesis, serine palmitoyltransferase, and a specific inhibitor of the same en...

journal_title：Biochemical and biophysical research communications

authors： Spilsberg B,Hanada K,Sandvig K

更新日期：2005-04-08 00:00:00

abstract：:Lateral diffusion coefficients (D) of two surface differentiation antigens (sIgM and Bp35) were determined on interferon-sensitive (-IFs) or resistant (-IFr) Daudi cells by fluorescence photobleaching, using monospecific FITC-anti-IgM or PE-anti-Leu 16 probes. For untreated Daudi -IFs, mean (D) were 5.8 and 5.3 (x10(-...

journal_title：Biochemical and biophysical research communications

authors： Balint E,Aszalos A,Grimley PM

更新日期：1988-12-15 00:00:00