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Hypoxia-induced transcriptional activation of vascular endothelial growth factor is inhibited by serum.

Abstract：

:Expression of vascular endothelial growth factor (VEGF) by cultured vascular smooth muscle cells was analyzed. Serum and hypoxia had nearly additive actions on VEGF mRNA expression. The function of the VEGF promoter in smooth muscle cells was analyzed using transient luciferase reporter assays. Serum and hypoxia stimulated expression of luciferase. The presence of hypoxia response element (HRE) was necessary for the hypoxic induction. AP-1 sequences located upstream of HRE and AP-2/Sp-1 sequences located downstream of HRE are not necessary. Hypoxic responses were best observed in serum-deprived cells. They were largely absent in serum-stimulated cells. Serum did not suppress the hypoxic response by interfering with the hypoxia sensor mechanism or with the signaling cascade that leads to the activation of HIF-1. It is concluded that growth-promoting cytokines regulate hypoxic gene induction in smooth muscle cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

D'Angelo G,Ladoux A,Frelin C

doi

10.1006/bbrc.1999.1947

subject

Has Abstract

pub_date

2000-01-07 00:00:00

pages

334-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)91947-2

journal_volume

267

pub_type

杂志文章

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