Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients.

abstract：:Two new human genes encoding putative G protein-coupled receptors were cloned from genomic DNA following a degenerate PCR strategy. The predicted amino acid sequences of the proteins encoded by these genes have the characteristic motifs of chemokine receptors. This prompted us to name these genes CKR-L1 and CKR-L3. Ne...

journal_title：Biochemical and biophysical research communications

authors： Zaballos A,Varona R,Gutiérrez J,Lind P,Márquez G

更新日期：1996-10-23 00:00:00

abstract：:Although leukotriene B4 (LTB4) has been reported to stimulate monocytes and neutrophils, its role on dendritic cell (DC) activity has not been examined. Here, we investigated the expression of LTB4 receptor and the effect of LTB4 on human DC chemotaxis. We analyzed LTB4 receptors, BLT1 and BLT2, by using RT-PCR. DCs e...

journal_title：Biochemical and biophysical research communications

authors： Shin EH,Lee HY,Bae YS

更新日期：2006-09-22 00:00:00

abstract：:Despite decades of intensive studies, the failure to identify plasmodesmata (PD) localization sequences has constrained our understanding of Tobacco mosaic virus (TMV) movement. Recently, we identified the first PD localization signal (major PLS) in the TMV movement protein (MP), which encompasses the first 50 amino a...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Huang C,Zeng J,Yu H,Li Y,Yuan C

更新日期：2020-01-01 00:00:00

abstract：:Unbalanced DNA mixture is still a difficult problem for forensic practice. DIP-STRs are useful markers for detection of minor DNA but they are not widespread in the human genome and having long amplicons. In this study, we proposed a novel type of genetic marker, termed DIP-SNP. DIP-SNP refers to the combination of IN...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Liu J,Wang J,Chen D,Liu Z,Shi J,Li Z,Li W,Zhang G,Du B

更新日期：2018-03-04 00:00:00

abstract：:Neurons extend neurites with an increased synthesis of phosphatidylcholine (PC) that is not only a membrane component but also a functional regulator with specific fatty acid composition. To analyze the local synthesis of the PC molecular species within neurons, we combined a compartmentalized culture system with matr...

journal_title：Biochemical and biophysical research communications

authors： Sugiyama E,Yao I,Setou M

更新日期：2018-01-01 00:00:00

abstract：:Hypothalamic neurons monitor peripheral energy status and produce signals to adjust food intake and energy expenditure to maintain homeostasis. However, the molecular mechanisms by which these signals are generated remain unclear. Fluctuations in the level of hypothalamic malonyl-CoA are known to serve as an intermedi...

journal_title：Biochemical and biophysical research communications

authors： Dai Y,Wolfgang MJ,Cha SH,Lane MD

更新日期：2007-08-03 00:00:00

abstract：:Kupffer cells, prepared 18 h after pretreatment of rats with a single dose of halothane, did carry TFA-adducts which were recognized on Western blots by a anti-TFA-antibody. Based on apparent molecular weight, the pattern of the major TFA-adducts within Kupffer cells was similar to that observed in hepatocytes. When k...

journal_title：Biochemical and biophysical research communications

authors： Christen U,Bürgin M,Gut J

更新日期：1991-02-28 00:00:00

abstract：:Pathogen-triggered generation of reactive oxidants, termed the oxidative burst, contributes to disease resistance in both plant and animal kingdoms. Since phospholipase D plays a key role in the neutrophil oxidative burst signaling cascade and is highly abundant in plants, we investigated its participation in the plan...

journal_title：Biochemical and biophysical research communications

authors： Schroeder Taylor AT,Low PS

更新日期：1997-08-08 00:00:00

abstract：PURPOSE:Recently, the newly identified embryonic stem cell marker, Zinc finger and SCAN domain containing 4 gene (ZSCAN4), which plays a key role in genomic stability by regulating telomere elongation, was shown to co-localize with TRF1 foci. This suggests that the interaction of ZSCAN4 with TRF1 functions in regulatio...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Gollahon LS

更新日期：2015-10-30 00:00:00

abstract：:Extracellular calcium-deprivation inhibited the proliferation of BALB/c 3T3 cells and this inhibition correlated with a loss of protein kinase C activity from the particulate fraction. Addition of calcium induced proliferation of the cells with the DNA synthetic activity returning to the control rate at 18 hours follo...

journal_title：Biochemical and biophysical research communications

authors： Donnelly TE Jr,Sittler R,Scholar EM

更新日期：1985-01-31 00:00:00

abstract：:G13 belongs to the G12-subfamily of heterotrimeric regulatory G-proteins. Employing specific antibodies, we isolated G alpha 13 from bovine brain by a four-step purification protocol combining conventional and affinity chromatography. The use of ethylene glycol as a protective agent influenced the elution properties o...

journal_title：Biochemical and biophysical research communications

authors： Harhammer R,Nürnberg B,Spicher K,Schultz G

更新日期：1994-10-28 00:00:00

abstract：:The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are not able to perceive some of the artificial sweeteners ...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Ha M,Meng XY,Khaleduzzaman M,Zhang Z,Li X,Cui M

更新日期：2012-10-19 00:00:00

abstract：:DNA fragmentation factors (DFF) form protein complexes consisting of nuclease DFF40/CAD and inhibitory chaperon DFF45/ICAD. Although activated caspase-3 has been shown to cleave DFF complexes with the release of active DFF40 and DNA fragmentation, the organ-specific mechanisms of DFF turnover during liver injury accom...

journal_title：Biochemical and biophysical research communications

authors： Xiang Y,Johnson EA,Zhang C,Huang G,Hayes RL,Wang KK,Svetlov SI

更新日期：2006-11-17 00:00:00

abstract：:During the late stage of homologous recombination in prokaryotes, RuvA binds to the Holliday junction intermediate and executes branch migration in association with RuvB. The RuvA subunits form two distinct complexes with the Holliday junction: complex I with the single RuvA tetramer on one side of the four way juncti...

journal_title：Biochemical and biophysical research communications

authors： Mayanagi K,Fujiwara Y,Miyata T,Morikawa K

更新日期：2008-01-11 00:00:00

abstract：:One of the most important issues in stem cell research is to understand the regulatory mechanisms responsible for their differentiation. An extensive understanding of mechanism underlying the process of differentiation is crucial in order to prompt stem cells to perform a particular function after differentiation. To ...

journal_title：Biochemical and biophysical research communications

authors： Feng Z,Srivastava AS,Mishra R,Carrier E

更新日期：2004-11-26 00:00:00

abstract：:We have isolated cDNAs from normal human breast tissue and breast tumour cells that encode a protein (pez) with features of a novel non-receptor tyrosine phosphatase possessing N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family. Northern blot analysis indicates that pez is expressed in a ...

journal_title：Biochemical and biophysical research communications

authors： Smith AL,Mitchell PJ,Shipley J,Gusterson BA,Rogers MV,Crompton MR

更新日期：1995-04-26 00:00:00

abstract：:The human EBAG9 was previously identified as an estrogen responsive gene using CpG-genomic binding site cloning (Watanate et al., (1998) Mol. Cell. Biol. 18: 442-449). Recently it was revealed that the EBAG9 is identical with RCAS1 which is a cancer cell surface antigen implicated in immune escape. Here, we isolated a...

journal_title：Biochemical and biophysical research communications

authors： Ikeda K,Sato M,Tsutsumi O,Tsuchiya F,Tsuneizumi M,Emi M,Imoto I,Inazawa J,Muramatsu M,Inoue S

更新日期：2000-07-05 00:00:00

abstract：:Secretion of growth hormone (GH) exhibits marked sexual dimorphism in the rat. To examine the underlying mechanism that involves hypothalamic GH-releasing factor (GRF), we determined pituitary GRF receptor mRNA levels in male and female rats and compared their in vitro abilities to release GRF, an endogenous ligand fo...

journal_title：Biochemical and biophysical research communications

authors： Ono M,Miki N,Murata Y,Osaki E,Tamitsu K,Ri T,Yamada M,Demura H

更新日期：1995-11-22 00:00:00

abstract：:One of the monocytic cell colony stimulating factors produced by thymic myoid cells, a 100 kDa factor, was purified by reversed phase HPLC and found to be homologous to the secreted form of proteoglycan 1 (biglycan) core protein. This biglycan associated colony stimulating factor did not carry an immunological motif o...

journal_title：Biochemical and biophysical research communications

authors： Kamo I,Kikuchi A,Nonaka I,Yamada E,Kondo J

更新日期：1993-09-15 00:00:00

abstract：:Sensory transduction in the cochlea depends on regulated ion secretion and absorption. Results of whole-organ experiments suggested that Reissner's membrane may play a role in the control of luminal Cl(-). We tested for the presence of Cl(-) transport pathways in isolated mouse Reissner's membrane using whole-cell pat...

journal_title：Biochemical and biophysical research communications

authors： Kim KX,Marcus DC

更新日期：2010-04-02 00:00:00

abstract：:The findings from several studies have suggested that circulating miRNAs are imbalanced with the genesis of gastric cancer (GC). Both normal and cancer cells can generate and secrete exosomes, which are nanosized membrane vesicles that can transport microRNAs and proteins. Emerging evidence indicates that the exosomes...

journal_title：Biochemical and biophysical research communications

authors： Wang N,Wang L,Yang Y,Gong L,Xiao B,Liu X

更新日期：2017-11-25 00:00:00

abstract：:Two novel allergens, designated Mal f 2 and Mal f 3 according to the WHO/IUIS Allergen Nomenclature Subcommittee recommendation, were isolated from the lipophilic yeast Malassezia furfur cell extracts and the genes coding for those were cloned. Mal f 2 and Mal f 3 had apparent molecular weights of 21 kDa and 20 kDa, r...

journal_title：Biochemical and biophysical research communications

authors： Yasueda H,Hashida-Okado T,Saito A,Uchida K,Kuroda M,Onishi Y,Takahashi K,Yamaguchi H,Takesako K,Akiyama K

更新日期：1998-07-20 00:00:00

abstract：:Internal and environmental cues, including ambient temperature changes, regulate the timing of flowering in plants. Arabidopsis miR156 represses flowering and plays an important role in the regulation of temperature-responsive flowering. However, the molecular basis of miR156 processing at lower temperatures remains l...

journal_title：Biochemical and biophysical research communications

authors： Kim HE,Kim W,Lee AR,Jin S,Jun AR,Kim NK,Lee JH,Ahn JH

更新日期：2017-03-18 00:00:00

abstract：:We have developed a solid matrix immunoassay to determine the binding of interleukin-2 (IL-2) to specific gangliosides. The assay establishes that recombinant human IL-2 binds to ganglioside GD(1b) but not to any other gangliosides (GM(1), GM(2), GM(3), GD(1a), GD(2), GD(3), and GT(1b)). The binding varies with the ra...

journal_title：Biochemical and biophysical research communications

authors： Ravindranath MH,Gonzales A,Soh D,Nishimoto K,Tam WY,Bilchik A,Morton DL,O'Day S

更新日期：2001-05-04 00:00:00

abstract：:The number of accessible SH-groups was determined in membrane vesicles prepared from Escherichia coli growing in fermentation conditions at slightly alkaline pH on glucose with or without added formate. Addition of ATP or formate to the vesicles caused a approximately 1.4-fold increase in the number of accessible SH-g...

journal_title：Biochemical and biophysical research communications

authors： Mnatsakanyan N,Poladian A,Bagramyan K,Trchounian A

更新日期：2003-08-29 00:00:00

abstract：:We located a novel binding site for grayanotoxin on the cytoplasmic linkers of voltage-dependent cardiac (rH1) or skeletal-muscle (mu 1) Na(+) channel isoforms (segments S4-S5 in domains D1 and D4), using the alanine scanning substitution method. GTX-modification of Na(+) channels, transiently expressed in HEK 293 cel...

journal_title：Biochemical and biophysical research communications

authors： Maejima H,Kinoshita E,Yuki T,Yakehiro M,Seyama I,Yamaoka K

更新日期：2002-07-12 00:00:00

abstract：:Chalcone and stilbene synthases (CHS and STS) catalyze condensation reactions of p-coumaroyl-CoA and three C(2)-units from malonyl-CoA, but catalyze different cyclization reactions to produce naringenin chalcone and resveratrol, respectively. Condensing activities of wild-type CHS and STS as well as STS-C60S mutant we...

journal_title：Biochemical and biophysical research communications

authors： Suh DY,Kagami J,Fukuma K,Sankawa U

更新日期：2000-09-07 00:00:00

abstract：:Calyculin A (CL-A), a toxin isolated from the marine sponge Discodermia calyx, is a strong inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Although CL-A is known to induce rapid neurite retraction in developing neurons, the cytoskeletal dynamics of this retraction have remained unclear. Here, we investigated t...

journal_title：Biochemical and biophysical research communications

authors： Inutsuka A,Goda M,Fujiyoshi Y

更新日期：2009-12-25 00:00:00

abstract：:Interleukin (IL)-23 plays a predominant role in the development of autoimmune diseases by inducing IL-17-producing helper T (Th17) cells. The receptor for IL-23 consists of a heterodimer composed of the IL-12 receptor beta1 (IL-12Rbeta1) and the IL-23 receptor (IL-23R), which is mainly expressed on Th17 cells. A recen...

journal_title：Biochemical and biophysical research communications

authors： Sonobe Y,Liang J,Jin S,Zhang G,Takeuchi H,Mizuno T,Suzumura A

更新日期：2008-05-23 00:00:00

abstract：:The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme r...

journal_title：Biochemical and biophysical research communications

authors： Salzer W,Gerard C,McCall C

更新日期：1987-10-29 00:00:00