Leukotriene B4 stimulates human monocyte-derived dendritic cell chemotaxis.

abstract：:The actin regulator VASP localizes to cell-cell junctions and has been implicated in cell-cell adhesion. VASP is recruited to sites of actin dynamics by interactions with proline rich FPPPPP motifs. Zyxin and its relative LPP use FPPPPP motifs to recruit VASP to specific cellular locations, thus directing changes in a...

journal_title：Biochemical and biophysical research communications

authors： Hansen MD,Beckerle MC

更新日期：2008-06-20 00:00:00

abstract：:Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). Although it has been proved that Tipα is a strong inducer of epithelial-mesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Cu...

journal_title：Biochemical and biophysical research communications

authors： Chen G,Tang N,Wang C,Xiao L,Yu M,Zhao L,Cai H,Han L,Xie C,Zhang Y

更新日期：2017-03-04 00:00:00

abstract：:Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However, the function of OPN against the infection was poorly understood. Here, we demonstrate an importance of OPN on immune response and diseas...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Iwai A,Nakayama Y,Morimoto J,Takada A,Maruyama M,Kida H,Uede T,Miyazaki T

更新日期：2012-01-06 00:00:00

abstract：:Amino acid transporter plays an important role in regulating mTOR signaling pathway. This study investigated the effects of reduced dietary protein levels on amino acid transporters and mTOR signaling pathway. A total of 54 weaning pigs were randomly allocated into a 3 × 3 factorial design, followed by slaughtering th...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Wan X,Peng J,Xiong Q,Niu H,Li H,Chai J,Jiang S

更新日期：2017-04-01 00:00:00

abstract：:Chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase was expressed in E. coli by using a pET3a T7 RNA polymerase-based expression system and was purified to homogeneity. The kinase and bisphosphatase of the expressed bifunctional enzyme had kinetic properties identical to those of the native chicken live...

journal_title：Biochemical and biophysical research communications

authors： Li L,Yao WZ,Lange AJ,Pilkis SJ,Dong MQ,Yin Y,Xu GJ

更新日期：1995-04-26 00:00:00

abstract：:To study the hierarchical levels of stem cell targets for ABL-kinase domain mutations in CML, highly purified CD34+CD38- and CD34+CD38+ cell populations and their LTC-IC-derived progeny were analyzed in four patients at diagnosis (n=1) or in advanced phases (n=3) of their disease. In the single patient with early phas...

journal_title：Biochemical and biophysical research communications

authors： Sorel N,Bonnet ML,Guillier M,Guilhot F,Brizard A,Turhan AG

更新日期：2004-10-22 00:00:00

abstract：:The molecular conformations of Leu5- and Met5-enkephalins in aqueous and DMSO solutions were investigated by FT-IR and laser Raman spectroscopic methods. The amide I, II, and III regions in the FT-IR spectra of Leu5- and Met5-enkephalins in aqueous solution were analyzed by performing Fourier self-deconvolution of the...

journal_title：Biochemical and biophysical research communications

authors： Renugopalakrishnan V,Rapaka RS,Collette TW,Carreira LA,Bhatnagar RS

更新日期：1985-02-15 00:00:00

abstract：:Human thymidine phosphorylase (dThdPase) is thought to be identical to an angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF). However, the whole amino acid sequence of dThdPase is still unknown. N-terminal amino acid sequencing of dThdPase isolated from human placenta gave the sequence Ac-A...

journal_title：Biochemical and biophysical research communications

authors： Miyadera K,Dohmae N,Takio K,Sumizawa T,Haraguchi M,Furukawa T,Yamada Y,Akiyama S

更新日期：1995-07-26 00:00:00

abstract：:DNA fragmentation factors (DFF) form protein complexes consisting of nuclease DFF40/CAD and inhibitory chaperon DFF45/ICAD. Although activated caspase-3 has been shown to cleave DFF complexes with the release of active DFF40 and DNA fragmentation, the organ-specific mechanisms of DFF turnover during liver injury accom...

journal_title：Biochemical and biophysical research communications

authors： Xiang Y,Johnson EA,Zhang C,Huang G,Hayes RL,Wang KK,Svetlov SI

更新日期：2006-11-17 00:00:00

abstract：:The hyaluronan receptor for endocytosis (HARE), or Stabilin-2, is the mammalian endocytic clearance receptor for HA, heparin, advanced glycation end-products, acetylated and oxidized low-density lipoproteins and collagen N-terminal propeptides. This large 2551 amino acid receptor is encoded by a gene that covers over ...

journal_title：Biochemical and biophysical research communications

authors： Hare AK,Harris EN

更新日期：2015-01-02 00:00:00

abstract：:Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum (ER)-membrane associated Ca(2+) sensor which activates store-operated Ca(2+) entry (SOCE). The homologue, STIM2 possesses a high sequence identity to STIM1 ( approximately 61%), while its role in SOCE seems to be distinct from that of STIM1. In order t...

journal_title：Biochemical and biophysical research communications

authors： Zheng L,Stathopulos PB,Li GY,Ikura M

更新日期：2008-04-25 00:00:00

abstract：:Follicle-stimulating hormone (FSH) levels increase estrogen biosynthesis in obese menopausal women. Ovariectomized mice and 3T3-L1 cells were used to explore estrogen biosynthesis in the decline of ovarian function. After ovariectomy, lipid deposition, and FSH and estrogen levels changed, and feed intake increased sig...

journal_title：Biochemical and biophysical research communications

authors： Cui H,Zhao G,Wen J,Tong W

更新日期：2018-01-15 00:00:00

abstract：:Cellular response to oxidative stress is a complex process that is often connected to cell cycle regulation. The present study examines the effect of H(2)O(2) on cell cycle regulation and involvement of reactive oxygen species (ROS) in these H(2)O(2)-induced responses in a p53-deficient human lung carcinoma cell line,...

journal_title：Biochemical and biophysical research communications

authors： Chung YW,Jeong DW,Won JY,Choi EJ,Choi YH,Kim IY

更新日期：2002-05-17 00:00:00

abstract：:Actin-related proteins share significant homology with conventional actins and are classified into subfamilies based on the similarity of their sequences and functions. The Arp4 subfamily of Arps is localized in the nucleus, and a mammalian isoform, ArpNbeta (also known as BAF53), is a component of the chromatin remod...

journal_title：Biochemical and biophysical research communications

authors： Kuroda Y,Oma Y,Nishimori K,Ohta T,Harata M

更新日期：2002-11-29 00:00:00

abstract：:HIV-1 protease inhibitors are effective in HIV/AIDS therapy, although drug resistance is a severe problem. This study examines the effects of four investigational inhibitors against HIV-1 protease with drug resistant mutations of V32I, I47V and V82I (PRTri) that model the inhibitor-binding site of HIV-2 protease. Thes...

journal_title：Biochemical and biophysical research communications

authors： Pawar S,Wang YF,Wong-Sam A,Agniswamy J,Ghosh AK,Harrison RW,Weber IT

更新日期：2019-06-30 00:00:00

abstract：:The flavanol (-)-epicatechin has been found to protect against damage inflicted by peroxynitrite, an inflammatory intermediate. Here, epicatechin was tested in systems of increasing complexity. The compound efficiently protected against nitration of protein tyrosine residues by peroxynitrite (IC(50) approximately 0.02...

journal_title：Biochemical and biophysical research communications

authors： Schroeder P,Klotz LO,Buchczyk DP,Sadik CD,Schewe T,Sies H

更新日期：2001-07-20 00:00:00

abstract：:Because of their structural similarity and ubiquitous distribution as actin binding proteins, plant profilins represent important cross-reactive allergens for almost 20% of patients suffering from Type I allergy to pollen and other plant products. The cDNAs coding for three birch profilin variants (Tyr44, Glu47, and A...

journal_title：Biochemical and biophysical research communications

authors： Vrtala S,Wiedemann P,Mittermann I,Eichler HG,Sperr WR,Valent P,Kraft D,Valenta R

更新日期：1996-09-04 00:00:00

abstract：:Cepharanthine is a medicinal plant-derived natural compound which possesses potent anti-cancer properties. However, there is little report about its effects on lung cancer cells. In this study, we investigated the effects of cepharanthine on the cell viability and apoptosis in human non-small-cell lung cancer H1299 an...

journal_title：Biochemical and biophysical research communications

authors： Hua P,Sun M,Zhang G,Zhang Y,Tian X,Li X,Cui R,Zhang X

更新日期：2015-05-01 00:00:00

abstract：:Endothelin (ET)-1 and big ET-1 both caused contraction of isolated porcine coronary arteries, but the potency of big ET-1 was 1/100-1/200 that of ET-1. These responses were independent of the vascular endothelium. Phosphoramidon blocked the vasoconstriction caused by 30 nM big ET-1, but was ineffective on the action o...

journal_title：Biochemical and biophysical research communications

authors： Fukuroda T,Noguchi K,Tsuchida S,Nishikibe M,Ikemoto F,Okada K,Yano M

更新日期：1990-10-30 00:00:00

abstract：:Distribution of mRNA expression of 1,25-dihydroxyvitamin D3 receptor (VDR) and 25-hydroxyvitamin D3-24-hydroxylase (24-OHase) along the microdissected rat nephron segments was examined by reverse transcription-polymerase chain reaction (RT-PCR) technique. VDR mRNA was abundantly expressed in cortical segments (glomeru...

journal_title：Biochemical and biophysical research communications

authors： Iida K,Taniguchi S,Kurokawa K

更新日期：1993-07-30 00:00:00

abstract：:The nonamer 5'd(CTCAGCCTC) 3' 1 has been reacted with cis-diamminediaquaplatinum(II) in water at pH 4.2. The major reaction product was shown by enzymatic digestion and 1H NMR to be the d(ApG)cis-Pt(NH3)2 chelate [cis-Pt(NH3)2[d(CTCAGCCTC)-N7(4),N7(5)]] 1-Pt. When mixed with its complementary strand 2, 1-Pt forms a B ...

journal_title：Biochemical and biophysical research communications

authors： Fouchet MH,Gauthier C,Guittet E,Girault JP,Igolen J,Chottard JC

更新日期：1992-01-31 00:00:00

abstract：:Enzymatic hydrolysis of the synthetic substrate succinyl-Ala-Ala-Pro-Xxx-pNA (where Xxx=Leu, Asp or Lys) catalyzed by bovine chymotrypsin (CHYM) or Streptomyces griseus protease B (SGPB) has been studied at different pH values in the pH range 3-11. The pH optima for substrates having Leu, Asp, and Lys have been found ...

journal_title：Biochemical and biophysical research communications

authors： Qasim MA,Song J,Markley JL,Laskowski M Jr

更新日期：2010-10-01 00:00:00

abstract：:Extra long PCR analysis of mitochondrial DNA (mtDNA) isolated from skeletal muscle of humans of different ages revealed three phenomena: (i) the amount of normal length mtDNA (16.5 kb) was progressively reduced with age, such that the cells of old age individuals (about 90 years) contained little, or undetectable amou...

journal_title：Biochemical and biophysical research communications

authors： Kovalenko SA,Kopsidas G,Kelso JM,Linnane AW

更新日期：1997-03-06 00:00:00

abstract：:The immunosuppressant FK506 inhibits thymocyte positive selection. Calcineurin, a FK506-sensitive Ca2+/calmodulin-dependent protein phosphatase, is presumed to be involved in this event without direct evidence. We have previously shown that moderate stimulation of CD4(+)CD8(+) thymocytes with a combination of the calc...

journal_title：Biochemical and biophysical research communications

authors： Kuwata T,Asada A,Ohoka Y,Mukai M,Miyaike M,Iwata M

更新日期：1998-06-18 00:00:00

abstract：:DC-SIGN, a C-type lectin receptor expressed in dendritic cells (DCs), has been identified as a receptor for human immunodeficiency virus type 1, hepatitis C virus, Ebola virus, cytomegalovirus, dengue virus, and the SARS coronavirus. We used H5N1 pseudotyped and reverse-genetics (RG) virus particles to study their abi...

journal_title：Biochemical and biophysical research communications

authors： Wang SF,Huang JC,Lee YM,Liu SJ,Chan YJ,Chau YP,Chong P,Chen YM

更新日期：2008-09-05 00:00:00

abstract：:Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation of sarcosine (N-methylglycine)...

journal_title：Biochemical and biophysical research communications

authors： Luka Z,Pakhomova S,Loukachevitch LV,Newcomer ME,Wagner C

更新日期：2014-07-11 00:00:00

abstract：:Secreted frizzled-related protein 5 (Sfrp5), an anti-inflammatory adipocytokine secreted by adipocytes, plays an important role in energy metabolism. Studies have shown that Sfrp5 plays a salutary role in the regulation of lipid metabolism, but its specific mechanism needs further study. In this study, we showed a low...

journal_title：Biochemical and biophysical research communications

authors： Zhao A,Jiang F,Yang G,Liu H,Li L

更新日期：2019-04-30 00:00:00

abstract：:Oct4-Sox2-Nanog transcriptional networks are critical for the maintenance of embryonic stem (ES) cell self-renewal and induction of pluripotency. However, in transcription factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), Nanog is initially dispensable and Oct4 remains the sole...

journal_title：Biochemical and biophysical research communications

authors： Moon JH,Yun W,Kim J,Hyeon S,Kang PJ,Park G,Kim A,Oh S,Whang KY,Kim DW,Yoon BS,You S

更新日期：2013-02-15 00:00:00

abstract：:A novel hemoglobin variant was detected by electrospray ionization mass spectrometry. Hb Zurich-Hottingen is characterized by an Asn --> Ser replacement in the alpha-chain at position 9 as confirmed by DNA analysis. This hemoglobin variant is silent in isoelectric focusing, reversed-phase chromatography, and cation-ex...

journal_title：Biochemical and biophysical research communications

authors： Troxler H,Neuheiser F,Kleinert P,Kuster T,Heizmann CW,Sack R,Hunziker P,Neuhaus TJ,Schmid M,Frischknecht H

更新日期：2002-04-12 00:00:00

abstract：:ASC2 structure has been well defined by 1141 NOE experimental restraints. The model consists of five alpha helices. alpha-Helices are connected by short random structure loops. The sole exception is the loop connecting helices 2 and 3, which has a 20-residue length. Folding generally agrees with the folding of recentl...

journal_title：Biochemical and biophysical research communications

authors： Espejo F,Patarroyo ME

更新日期：2006-02-17 00:00:00