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Reprogramming of mouse fibroblasts into induced pluripotent stem cells with Nanog.

Abstract：

:Oct4-Sox2-Nanog transcriptional networks are critical for the maintenance of embryonic stem (ES) cell self-renewal and induction of pluripotency. However, in transcription factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs), Nanog is initially dispensable and Oct4 remains the sole factor that could not be substituted/omitted. Here, we show that mouse fibroblasts could be reprogrammed into iPSCs by Nanog and Bmi1, which replaces Sox2, Klf4, and c-Myc, in the absence of Oct4. Furthermore, we show that in the presence of shh agonists (oxysterol and purmophamine), which replaces the function of Bmi1, a single transcription factor, Nanog is sufficient to reprogram mouse fibroblasts into iPSCs. Nanog-induced iPSCs resemble mESCs in terms of morphology, global gene expression profiles, epigenetic status and pluripotency both in vitro and in vivo. These findings support that Nanog can replace the Oct4 for the somatic cell reprogramming and underlie the mechanisms of Nanog in reprogramming process.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Moon JH,Yun W,Kim J,Hyeon S,Kang PJ,Park G,Kim A,Oh S,Whang KY,Kim DW,Yoon BS,You S

doi

10.1016/j.bbrc.2012.12.149

subject

Has Abstract

pub_date

2013-02-15 00:00:00

pages

444-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)00094-6

journal_volume

431

pub_type

杂志文章

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