Conversion of angiotensin-1 to angiotensin-2 by a latent endothelial cell peptidyl dipeptidase that is not angiotensin-converting enzyme.

abstract：:Three dnaK gene homologs have been cloned and sequenced from cyanobacterium Synechococcus sp. PCC7942 using a set of primers designed from two conserved regions of known dnaK genes. This is the first example of triple genes for dnaK from prokaryotic cells. These three genes were derived from different loci of the chro...

journal_title：Biochemical and biophysical research communications

authors： Nimura K,Yoshikawa H,Takahashi H

更新日期：1994-05-30 00:00:00

abstract：:Tumour-secreted vascular endothelial growth factor (VEGF) exerts a number of effects which are important in tumour pathology, including stimulation of angiogenesis and permeabilisation of tumour-associated vasculature. In this study we have examined the possibility that VEGF may also play an autocrine role in tumour g...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Earl HM,Baban D,Shoaibi M,Fabra A,Kerr DJ,Seymour LW

更新日期：1995-12-26 00:00:00

abstract：:Extra long PCR analysis of mitochondrial DNA (mtDNA) isolated from skeletal muscle of humans of different ages revealed three phenomena: (i) the amount of normal length mtDNA (16.5 kb) was progressively reduced with age, such that the cells of old age individuals (about 90 years) contained little, or undetectable amou...

journal_title：Biochemical and biophysical research communications

authors： Kovalenko SA,Kopsidas G,Kelso JM,Linnane AW

更新日期：1997-03-06 00:00:00

abstract：:Calreticulin has multiple functions, diverse cellular locations, and putative isoforms. It likely maintains integrin avidity by binding alpha integrin cytoplasmic tails and is a surface lectin which triggers cell spreading. In the present study, we have immunocaptured a cell surface complex from B16 mouse melanoma cel...

journal_title：Biochemical and biophysical research communications

authors： Zhu Q,Zelinka P,White T,Tanzer ML

更新日期：1997-03-17 00:00:00

abstract：:Rex-1 is a zinc finger-containing gene that is expressed in embryonal carcinoma (EC) cells and embryonic stem (ES) cells. Upon differentiation with retinoic acid (RA), transcription of the Rex-1 gene decreases rapidly. Analysis of the 5'-flanking region of the Rex-1 gene identified a consensus motif for the octamer fa...

journal_title：Biochemical and biophysical research communications

authors： Rosfjord E,Rizzino A

更新日期：1994-09-30 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a cancer arising from the nasopharynx epithelium. Long non-coding RNAs (lnc RNA) play a critical role in various biological processes such as cell growth, embryonic development, and tumorigenesis. In the study, for the first time, we discovered that lnc RNA taurine upregulated gene 1 ...

journal_title：Biochemical and biophysical research communications

authors： Qian W,Ren Z,Lu X

更新日期：2019-01-29 00:00:00

abstract：:We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Binding of p53 to the kin...

journal_title：Biochemical and biophysical research communications

authors： Ababneh M,Götz C,Montenarh M

更新日期：2001-05-04 00:00:00

abstract：:Human neuropeptide Y (NPY) analog ANA-NPY or [L17, Q19, A20, A23, L28, L31]NPY (13-36)-amide binds weakly to postjunctional receptors to raise blood pressure but binds tightly to prejunctional receptors to inhibit neurotransmitter release. ANA-NPY forms a well-conserved anti-parallel helical structure overlapping E23-...

journal_title：Biochemical and biophysical research communications

authors： Barden JA

更新日期：1995-10-04 00:00:00

abstract：:Erythroid band 4.1 enhances the binding of erythroid spectrin to phosphatidylserine vesicles under conditions of ionic strength and at protein concentrations similar to those in the red cell. The extent of enhancement depends on the concentration of band 4.1; at 2 microM 4.1, spectrin binding increases approximately 1...

journal_title：Biochemical and biophysical research communications

authors： Takeshita K,MacDonald RI,MacDonald RC

更新日期：1993-02-26 00:00:00

abstract：:5'-RACE and genomic cloning were used to determine that the mouse TBP (mTBP) gene consists of one 5'-terminal non-coding exon followed by seven protein-coding exons. The region upstream of the first exon lacks a TATA-box. Hence, as with the case of other genes carrying TATA-less promoter, transcription starts from a c...

journal_title：Biochemical and biophysical research communications

authors： Ohbayashi T,Schmidt EE,Makino Y,Kishimoto T,Nabeshima Y,Muramatsu M,Tamura T

更新日期：1996-08-05 00:00:00

abstract：:Receptor binding properties of the hemoglobin-derived nonapeptide VV-hemorphin 7 (Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe-OH) were studied using both the unlabelled form and tritium-labelled derivative of the peptide. In binding studies using selective opioid radioligands, VV-hemorphin 7 exhibited a rank order of potency ...

journal_title：Biochemical and biophysical research communications

authors： Szikra J,Benyhe S,Orosz G,Darula Z,Piot JM,Fruitier I,Monory K,Hanoune J,Borsodi A

更新日期：2001-03-02 00:00:00

abstract：:The cAMP response element binding protein (CREB) is expressed at constitutively low levels in most cell types, and the CREB promoter possesses features that are typical of house-keeping genes. Since the CREB promoter also contains sequences which can mediate cAMP responsiveness in transfection experiments, it has been...

journal_title：Biochemical and biophysical research communications

authors： Crosson SM,Davies GF,Roesler WJ

更新日期：1996-10-23 00:00:00

abstract：:It has been demonstrated in several animal species that neuropeptide Y (NPY) exerts a modulatory effect on luteinizing hormone (LH) secretion. However, whether NPY plays a similar role also in humans has yet to be determined. Therefore, in this study we examined the effect of human NPY on the anterior pituitary hormon...

journal_title：Biochemical and biophysical research communications

authors： Watanobe H,Nigawara T,Anzai J,Sakihara S,Kageyama K,Nasushita R,Sasaki S,Habu S,Takebe K

更新日期：1994-04-29 00:00:00

abstract：:We selected the quinolone-resistant mutants from the protein F deficient Pseudomonas aeruginosa. The mutants showed cross-resistance to tetracycline, minocycline and chloramphenicol, but not to the beta-lactam antibiotics. The MIC of ofloxacin (OFLX) against the mutants, but not in the parent, became 2 to 4 times lowe...

journal_title：Biochemical and biophysical research communications

authors： Lei Y,Sato K,Nakae T

更新日期：1991-08-15 00:00:00

abstract：:Prostaglandin (PG)E(2) is a critical lipid mediator connecting chronic inflammation to cancer. The anti-carcinogenic epigallocatechin-3-gallate (EGCG) from green tea (Camellia sinensis) suppresses cellular PGE(2) biosynthesis, but the underlying molecular mechanisms are unclear. Here, we investigated the interference ...

journal_title：Biochemical and biophysical research communications

authors： Koeberle A,Bauer J,Verhoff M,Hoffmann M,Northoff H,Werz O

更新日期：2009-10-16 00:00:00

abstract：:To evaluate the immunomodulatory effects of histamine in vivo, we analyzed an experimental syngenic tumor model using a colon adenocarcinoma cell line, CT-26, in Balb/c mice. In this model, distinct tumor growth was observed around 6 days after inoculation. Daily administration of cimetidine (0.12 mg/kg/day) significa...

journal_title：Biochemical and biophysical research communications

authors： Takahashi K,Tanaka S,Ichikawa A

更新日期：2001-03-01 00:00:00

abstract：:Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physio...

journal_title：Biochemical and biophysical research communications

authors： Ravid A,Koren R,Novogrodsky A,Liberman UA

更新日期：1984-08-30 00:00:00

abstract：:Plants use specialized root outgrowths, termed root hairs, to enhance acquisition of nutrients and water, help secure anchorage, and facilitate interactions with soil microbiome. One of the major regulators of this process is GLABRA2 (GL2), a transcriptional repressor of root hair differentiation. However, regulation ...

journal_title：Biochemical and biophysical research communications

authors： Wu R,Citovsky V

更新日期：2017-07-01 00:00:00

abstract：:Hepatocyte growth factor/scatter factor (HGF) is a multifunctional growth factor that is linked to the initiation and/or progression of numerous malignancies. HGF also alters cancer cell responses to DNA damaging cytotoxic agents. Many cell responses to Met activation require alterations in metabolic activity but how ...

journal_title：Biochemical and biophysical research communications

authors： Xia S,Laterra J

更新日期：2006-07-14 00:00:00

abstract：:Cholinesterases in the oat cell were found to be distributed in the cell wall (50%) and cytoplasm (42%). Activity of the cytosolic enzyme was inhibited about 80% by 1 mM Ca2+. The enzyme activity was also inhibited by Mn2+, but no inhibition by Mg2+ was observed. Effects of red light and calcium ion on the enzyme acti...

journal_title：Biochemical and biophysical research communications

authors： Kim HY,Kim TI,Kim HK,Chae Q

更新日期：1990-05-31 00:00:00

abstract：:Isolated nuclei from mammalian cells contain a Ca(2+)-dependent endonuclease [1]. The produced DNA fragmentation is a necessary step in the sequence of events resulting in apoptosis [2]. We report here that zinc inhibits the DNA fragmentation in dependence of the free Ca2+ concentrations, suggesting that a balance bet...

journal_title：Biochemical and biophysical research communications

authors： Lohmann RD,Beyersmann D

更新日期：1993-02-15 00:00:00

abstract：:Reaction of metmyoglobin with peroxides is known to involve the formation, possibly via a porphyrin radical-cation, of a ferryl (iron(IV)-oxo) species and a protein radical; there is a little information available as to which of these species initiates the damage which is observed on incubating membrane fractions with...

journal_title：Biochemical and biophysical research communications

authors： Newman ES,Rice-Evans CA,Davies MJ

更新日期：1991-09-30 00:00:00

abstract：:In a primary cell culture system of fetal rat brain, the calmodulin-dependent protein-kinase IV (CaMKIV) could be induced by the thyroid hormone T3 in a time- and concentration-dependent manner, provided the tissue was excised not later than day 15 of gestation (E15) (Krebs et al., J. Biol. Chem. 271, 11055, 1996). We...

journal_title：Biochemical and biophysical research communications

authors： Krebs J,Wilson A,Kisielow P

更新日期：1997-12-18 00:00:00

abstract：:Pyruvate kinase M2 (PKM2) functions as an important rate-limiting enzyme of aerobic glycolysis that is involved in tumor initiation and progression. However, there are few studies on effective PKM2 inhibitors. Gliotoxin is a marine-derived fungal secondary metabolite with multiple biological activities, including immu...

journal_title：Biochemical and biophysical research communications

authors： Tang W,Liu ZL,Mai XY,Qi X,Li DH,Gu QQ,Li J

更新日期：2020-07-30 00:00:00

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP) localized on the plasma membrane plays a central role in various normal biological responses including tissue remodeling, wound heeling, and angiogenesis and in cancer cell invasion and metastasis, by functioning as a collagenase and activating other matrix metallopro...

journal_title：Biochemical and biophysical research communications

authors： Miyata T,Ohnishi H,Suzuki J,Yoshikumi Y,Ohno H,Mashima H,Yasuda H,Ishijima T,Osawa H,Satoh K,Sunada K,Kita H,Yamamoto H,Sugano K

更新日期：2004-10-08 00:00:00

abstract：:Autoimmune diseases are characterized by the presence of autoantibodies often restricted to host proteins exhibiting charge rich domains. Charged polypeptides elicit strong immune responses, and cationized bovine serum albumin and other cationic proteins are significantly more immunogenic than their less charged count...

journal_title：Biochemical and biophysical research communications

authors： Dohlman JG,Pillion DJ,Rokeach LA,Ramprasad MP

更新日期：1991-12-16 00:00:00

abstract：:In inflammatory cells, intracellular cAMP concentration is regulated by cyclic nucleotide phosphodiesterases 4. Therefore, PDE4 inhibition appears as a rational goal for treating acute or chronic inflammatory diseases. Selective PDE4 inhibitors have been developed, but due to unwanted side effects, search for new sele...

journal_title：Biochemical and biophysical research communications

authors： Reimund JM,Raboisson P,Pinna G,Lugnier C,Bourguignon JJ,Muller CD

更新日期：2001-10-26 00:00:00

abstract：:The 3' untranslated region (UTR) of the hepatitis C virus (HCV) is believed to function in the initiation and regulation of viral RNA replication and protein translation by interacting with the viral and host components. To examine host proteins interacting with the HCV 3'UTR, biotinylated 3'(+)UTR, and its reverse co...

journal_title：Biochemical and biophysical research communications

authors： Tingting P,Caiyun F,Zhigang Y,Pengyuan Y,Zhenghong Y

更新日期：2006-09-01 00:00:00

abstract：:The secretory response of purified beta cells was studied employing a newly developed microperifusion technique. In control experiments, initial high insulin release up to 50 minutes followed by a steady state basal level was observed up to five hours. The changes in hydrodynamic pressure of perifusion produced small,...

journal_title：Biochemical and biophysical research communications

authors： Bandisode MS

更新日期：1988-03-15 00:00:00

abstract：:We report the construction of a cDNA clone encoding a functional GM2-activator protein. The sequence of the complete 5' end of the coding region was determined by direct nucleotide sequencing of a fragment generated by multiple RACE PCR procedures from Hela cell cDNA. Specific oligonucleotides were synthesized from th...

journal_title：Biochemical and biophysical research communications

authors： Xie B,McInnes B,Neote K,Lamhonwah AM,Mahuran D

更新日期：1991-06-28 00:00:00