The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells.

abstract：:Botulinum neurotoxins (BoNTs) are produced as progenitor toxin complexes (PTCs) by Clostridium botulinum. The PTCs are composed of BoNT and non-toxic neurotoxin-associated proteins (NAPs), which serve to protect and deliver BoNT through the gastrointestinal tract in food borne botulism. HA33 is a key NAP component tha...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Lam KH,Kruel AM,Perry K,Rummel A,Jin R

更新日期：2014-04-04 00:00:00

abstract：:Signal regulatory protein α (SIRPα) is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is abundantly expressed on dendritic cells and macrophages. Wild-type (WT) C57BL/6 mice are known to be resistant to Leishmania major infection. We here found t...

journal_title：Biochemical and biophysical research communications

authors： Morimoto N,Murata Y,Motegi S,Suzue K,Saito Y,Okazawa H,Ohnishi H,Kotani T,Kusakari S,Ishikawa O,Matozaki T

更新日期：2010-10-22 00:00:00

abstract：:Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporo-spatial manner. The zinc-finger-containing transcription factor has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regu...

journal_title：Biochemical and biophysical research communications

authors： Liu H,Zhu C,Luo J,Wang Y,Li D,Li Y,Zhou J,Yuan W,Ou Y,Liu M,Wu X

更新日期：2004-07-16 00:00:00

abstract：:Increasing antimicrobial drug resistance is a global threat especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as an important bottleneck that prevents a sufficient antibacterial effect to be achieved at low doses of the antibiotics. In particul...

journal_title：Biochemical and biophysical research communications

authors： Citak F,Ghai I,Rosenkötter F,Benier L,Winterhalter M,Wagner R

更新日期：2018-01-01 00:00:00

abstract：:CRTH2, the second receptor for prostaglandin D(2) (PGD(2)), is thought to play a role in allergic inflammations through the induction of chemotactic migration and/or the activation of Th2, eosinophils, and basophils, in humans. We previously identified the mouse CRTH2 homolog of human CRTH2 and suggest that animal mod...

journal_title：Biochemical and biophysical research communications

authors： Hirai H,Abe H,Tanaka K,Takatsu K,Sugamura K,Nakamura M,Nagata K

更新日期：2003-08-08 00:00:00

abstract：:The phosphonodifluoromethyl phenylalanine (F2Pmp) is superior to phosphonomethyl phenylalanine (Pmp) as a non-hydrolyzable phosphotyrosine (pTyr) mimetic. The difluoromethyl moiety increases the inhibitory potency of a F2Pmp-containing peptide over a Pmp-containing counterpart by 1000-fold toward the protein tyrosine ...

journal_title：Biochemical and biophysical research communications

authors： Chen L,Wu L,Otaka A,Smyth MS,Roller PP,Burke TR Jr,den Hertog J,Zhang ZY

更新日期：1995-11-22 00:00:00

abstract：:We have obtained the complete coding sequence of a highly conserved heparan sulfate proteoglycan which we previously characterized biochemically after isolation from rat brain. An open reading frame of 558 amino acids encodes a protein with a molecular mass of 62 kDa containing three peptide sequences present in the i...

journal_title：Biochemical and biophysical research communications

authors： Karthikeyan L,Maurel P,Rauch U,Margolis RK,Margolis RU

更新日期：1992-10-15 00:00:00

abstract：:Isocitrate dehydrogenase 1 (IDH1) mutations have been detected in gliomas and other tumors. Although IDH1 catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate (α-KG) in cytosol, mutated IDH1 proteins possess the ability to change α-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Several mono...

journal_title：Biochemical and biophysical research communications

authors： Fujii Y,Ogasawara S,Oki H,Liu X,Kaneko MK,Takano S,Kato Y

更新日期：2015-10-30 00:00:00

abstract：:Strategy to differentiate stem cells into insulin producing cells (IPCs) in vitro has been a promising one to get cell source of β-cell replacement therapy for diabetes. It has been suggested that islets and neurons share features and nestin-positive cells could differentiate into IPCs. We have recently developed a th...

journal_title：Biochemical and biophysical research communications

authors： Hur J,Yang JM,Choi JI,Yun JY,Jang JH,Kim J,Kim JY,Oh IY,Yoon CH,Cho HJ,Park YB,Kim HS

更新日期：2012-02-24 00:00:00

abstract：:Three corticostatic peptides (GP-CS1, GP-CS2 and GP-CS3) were purified from extracts of guinea pig bone marrow. Each was identified on the basis of their ability to inhibit the secretion of corticosterone by isolated rat adrenal cells stimulated by ACTH. GP-CS1 and GP-CS2 were found to be 31 residues in length, rich i...

journal_title：Biochemical and biophysical research communications

authors： Hu J,Bennett HP,Lazure C,Solomon S

更新日期：1991-10-31 00:00:00

abstract：:To determine whether the cytokine interleukin (IL)-6 induces heat shock protein (HSP) 72 gene expression in skeletal muscle, 18 healthy, young men had either a high dose of IL-6 (HiIL-6; n=6), low dose IL-6 (LoIL-6; n=6), or saline (CON; n=6) infused into one femoral artery for 3h. Muscle biopsies were obtained from t...

journal_title：Biochemical and biophysical research communications

authors： Febbraio MA,Steensberg A,Fischer CP,Keller C,Hiscock N,Pedersen BK

更新日期：2002-09-06 00:00:00

abstract：:Aggregation of proteins is a frequent occurrence during their transition from random coil to native structure. The influence of cyclodextrins in the refolding of carbonic anhydrase under aggregating conditions was studied. Cyclodextrin prevented formation of protein aggregates during renaturation of carbonic anhydrase...

journal_title：Biochemical and biophysical research communications

authors： Karuppiah N,Sharma A

更新日期：1995-06-06 00:00:00

abstract：:Glucocorticoids cause the delayed wound healing by suppressing inflammation that is required for wound healing process. Adipose tissue-derived mesenchymal stem cells (AT-MSCs) play an important role for wound healing by their cytokine productions including stromal derived factor 1 (SDF-1). However, it has not been cle...

journal_title：Biochemical and biophysical research communications

authors： Kato T,Khanh VC,Sato K,Takeuchi K,Carolina E,Yamashita T,Sugaya H,Yoshioka T,Mishima H,Ohneda O

更新日期：2017-11-18 00:00:00

abstract：:The conversion of the endogenous cellular prion protein to an abnormally folded isoform is a hallmark of transmissible spongiform encephalopathies. It occurs when a misfolded prion protein contacts the cellular PrP. Among the molecular partners suggested to be involved in the misfolding process, the glycosaminoglycans...

journal_title：Biochemical and biophysical research communications

authors： Martin R,Chantepie S,Chapuis J,Le-Duc A,Maftah A,Papy-Garcia D,Laude H,Petit JM,Gallet PF

更新日期：2011-10-28 00:00:00

abstract：:We investigated the involvement of G(i/o) protein in NO production following the activation of proteinase-activated receptor-4 (PAR-4) in cultured bovine aortic endothelial cells. AYPGKF-NH(2) (PAR-4 activating peptide), thrombin, and ionomycin induced a concentration-dependent NO production, with the maximal producti...

journal_title：Biochemical and biophysical research communications

authors： Momota F,Hirano K,Hirano M,Nishimura J,Kanaide H

更新日期：2006-04-07 00:00:00

abstract：:In the present study, we tested the anti-pancreatic cancer activity by AT406, a small-molecule antagonist of IAP (inhibitor of apoptosis proteins). In established (Panc-1 and Mia-PaCa-2 lines) and primary human pancreatic cancer cells, treatment of AT406 significantly inhibited cell survival and proliferation. Yet, sa...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Meng Q,Chen B,Shen H,Yan B,Sun B

更新日期：2016-09-09 00:00:00

abstract：:"Activated" glucocorticoid-receptor complexes purified about 3,000-fold from rat liver were found to bind to histone-agarose. Because of their tight binding, they could not be eluted from the column by high salt solution (3 M KCl) or low salt plus polyol buffer (50% ethylene glycol), but their binding could be disrupt...

journal_title：Biochemical and biophysical research communications

authors： Ueda K,Isohashi F,Okamoto K,Kokuhu I,Kimura K,Yoshikawa K,Sakamoto Y

更新日期：1988-03-15 00:00:00

abstract：:ERRalpha (estrogen receptor-related receptor alpha) is a member of the nuclear receptor superfamily. To further our understanding of the detailed molecular mechanism of transcriptional regulation by ERRalpha, we searched for ERRalpha-interacting proteins using a yeast two-hybrid system by screening a human mammary gla...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Chen B,Chen J,Lou G,Chen S,Zhou D

更新日期：2008-05-16 00:00:00

abstract：:PDX-1 plays a central role in differentiation of insulin-producing cells. We previously reported that exogenous PDX-1 protein can permeate cells and induce insulin gene expression in progenitor cells. These data suggest a strategy for facilitating differentiation into insulin-producing cells. Here we show the mechanis...

journal_title：Biochemical and biophysical research communications

authors： Noguchi H,Matsushita M,Matsumoto S,Lu YF,Matsui H,Bonner-Weir S

更新日期：2005-06-24 00:00:00

abstract：:The MoFe protein of the complex metalloenzyme nitrogenase folds as a heterotetramer containing two copies each of the homologous alpha and beta subunits, encoded by the nifD and the nifK genes respectively. Recently, the functional expression of a fusion NifD-K protein of nitrogenase was demonstrated in Azotobacter vi...

journal_title：Biochemical and biophysical research communications

authors： Lahiri S,Pulakat L,Gavini N

更新日期：2005-11-18 00:00:00

abstract：:Protein kinase C (PKC) is a family of serine/threonine kinases whose activity is controlled, in part, by phosphorylation on three conserved residues that are located on the catalytic domain of the enzyme, known as the activation-loop, the turn-motif, and the C-terminal hydrophobic-motif sites. Using a panel of phospho...

journal_title：Biochemical and biophysical research communications

authors： Freeley M,Volkov Y,Kelleher D,Long A

更新日期：2005-08-26 00:00:00

abstract：:The genome of a novel foot-and-mouth disease virus, HKN/2002, was 8104 nucleotides (nt) in length (excluding the poly(C) tract and poly(A) tail) and was composed of a 1042-nt 5'-untranslated region (UTR), a 6966-nt open reading frame, and a 93-nt 3'-UTR. Genome sequences of HKN/2002 and other known FMDV strains were c...

journal_title：Biochemical and biophysical research communications

authors： Feng Q,Yu H,Liu Y,He C,Hu J,Sang H,Ding N,Ding M,Fung YW,Lau LT,Yu AC,Chen J

更新日期：2004-10-08 00:00:00

abstract：:The major interaction site for tumor-promoting phorbol esters is the calcium-activated, phospholipid-dependent protein kinase (protein kinase C), a key-element in signal transduction. Binding of phorbol esters results in enzyme activation which mediates, at least in part, the action of these agents. We have investigat...

journal_title：Biochemical and biophysical research communications

authors： Roghani M,Da Silva C,Castagna M

更新日期：1987-02-13 00:00:00

abstract：:The amino acid sequence of biliverdin-IX beta reductase (EC1.3.1.24) from human liver was determined by automated Edman degradation of peptides generated by enzymatic and chemical cleavages. The enzyme was a single polypeptide chain of 204 amino acid residues, and its amino acid sequence had no significant homology to...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Komuro A,Nakano Y,Tomita M,Nakajima H

更新日期：1993-12-30 00:00:00

abstract：:The aim of this study was to investigate hormonal factors responsible for the huge increase in PRL receptors on the day of estrus in the rat mammary gland. For this purpose, ovariectomized rats were primed with E2 so as to reach a physiological serum concentration of E2 (21.5 +/- 1.2 pg/ml) and high PRL serum values (...

journal_title：Biochemical and biophysical research communications

authors： Guillaumot P,Sabbagh I,Bertrand J,Cohen H

更新日期：1986-03-28 00:00:00

abstract：:T box (Tbx) genes are a large family of transcription regulators that play critical roles in invertebrate and vertebrate development. Mutations in Tbx5 gene have been found to cause Holt-Oram syndrome (HOS) in humans. Partial dysfunction of TBX5 in mouse also causes HOS phenotype. Little is known about its molecular a...

journal_title：Biochemical and biophysical research communications

authors： He ML,Chen Y,Peng Y,Jin D,Du D,Wu J,Lu P,Lin MC,Kung HF

更新日期：2002-09-20 00:00:00

abstract：:Polyclonal antibodies have been obtained against a synthetic dodecapeptide identical to the aminoacid sequence 120-131 DSPIKDGVWPPE (inferred from its DNA sequence) of Paracoccus denitrificans cytochrome c oxidase subunit III. The antibodies had a titer higher than 1:10000 when tested against the antigen. These antibo...

journal_title：Biochemical and biophysical research communications

authors： Müller M,Labonia N,Azzi A

更新日期：1988-08-15 00:00:00

abstract：AIM/HYPOTHESIS:Diabetes is a hyperglycaemic disease treated by a set of allopathic drugs and natural biomolecules along with many variety of stem cell. We aim to investigate the role of these drugs in targeting common protein molecule in diabetes and its associated disease. We also aim to investigate the organ degenera...

journal_title：Biochemical and biophysical research communications

authors： Ambasta RK,Adeshara K,Yadav S,Kumar P

更新日期：2020-09-03 00:00:00

abstract：:Androgen receptors (sedimentation value approximately 4S and Stokes radius 2.8 nm) present in the cytoplasmic fraction obtained from prostates of castrated rats bind to DNA-Sepharose and double stranded DNA. A receptor fragment (sedimentation value approximately 3S and Stokes radius 2.3 nm) obtained from rat prostates...

journal_title：Biochemical and biophysical research communications

authors： Mulder E,Vrij AA,Brinkmann AO

更新日期：1983-08-12 00:00:00

abstract：:More than 80% of tumors that occur in the brain are malignant gliomas. The prognosis of glioma patients is still poor, which makes glioma an urgent subject of cancer research. Previous evidence and our present data show that PCBP2 is over-expressed in human glioma tissues and predicts poor outcome. However, the mechan...

journal_title：Biochemical and biophysical research communications

authors： Chen X,Hao B,Liu Y,Dai D,Han G,Li Y,Wu X,Zhou X,Yue Z,Wang L,Cao Y,Liu J

更新日期：2014-03-28 00:00:00