Tumor promoter chloroform is a potent protein kinase C activator.

Abstract:

:The major interaction site for tumor-promoting phorbol esters is the calcium-activated, phospholipid-dependent protein kinase (protein kinase C), a key-element in signal transduction. Binding of phorbol esters results in enzyme activation which mediates, at least in part, the action of these agents. We have investigated the effects of tumor promoter chloroform on protein kinase C activity. Like thrombin and 12-O-tetradecanoylphorbol-13-acetate (TPA), chloroform was able to activate protein kinase C in intact rabbit platelets. In addition, chloroform stimulated enzyme activity as well as TPA binding capacity in cell-free system. Scatchard analysis of the data has shown that chloroform increased the number of phorbol ester binding sites. Structurally related compounds, carbon tetrachloride and methylene chloride, activated the enzyme similarly.

authors

Roghani M,Da Silva C,Castagna M

doi

10.1016/0006-291x(87)91476-8

subject

Has Abstract

pub_date

1987-02-13 00:00:00

pages

738-44

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)91476-8

journal_volume

142

pub_type

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